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Insl3 Gene Detail
Summary
  • Symbol
    Insl3
  • Name
    insulin-like 3
  • Synonyms
    Ley I-L, Rlf, Rlnl
  • Feature Type
    protein coding gene
  • IDs
    MGI:108427
    NCBI Gene: 16336
  • Gene Overview
    MyGene.info: INSL3
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:71689252-71690577 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.43 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108427
protein coding gene Chr8:71689214-71690577 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033761
protein coding gene Chr8:72103123-72104485 (+)
A/J MGP_AJ_G0033744
protein coding gene Chr8:69165558-69166919 (+)
AKR/J MGP_AKRJ_G0033670
protein coding gene Chr8:71214694-71216056 (+)
BALB/cJ MGP_BALBcJ_G0033740
protein coding gene Chr8:69351588-69352950 (+)
C3H/HeJ MGP_C3HHeJ_G0033450
protein coding gene Chr8:71787301-71788663 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034258
protein coding gene Chr8:74846565-74847926 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031200
protein coding gene Chr8:63800001-63801337 (+)
CAST/EiJ MGP_CASTEiJ_G0032775
protein coding gene Chr8:71245300-71246662 (+)
CBA/J MGP_CBAJ_G0033428
protein coding gene Chr8:77494908-77496270 (+)
DBA/2J MGP_DBA2J_G0033582
protein coding gene Chr8:68891620-68892982 (+)
FVB/NJ MGP_FVBNJ_G0033524
protein coding gene Chr8:67989106-67990468 (+)
LP/J MGP_LPJ_G0033669
protein coding gene Chr8:72076777-72078139 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033571
protein coding gene Chr8:80036458-80037819 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034275
protein coding gene Chr8:71270105-71271467 (+)
PWK/PhJ MGP_PWKPhJ_G0032482
protein coding gene Chr8:68181210-68182572 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032319
protein coding gene Chr8:70217690-70218996 (+)
WSB/EiJ MGP_WSBEiJ_G0032891
protein coding gene Chr8:71619473-71620835 (+)



Homology
more
  • Human Ortholog
    INSL3, insulin like 3
  • Vertebrate Orthologs
    6
  • Human Ortholog
    INSL3, insulin like 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ley-I-L, RLF, RLNL
  • Links
    NCBI Gene ID: 3640
    neXtProt AC: NX_P51460
    UniProt: P51460

  • Chr Location
    19p13.11; chr19:17816513-17821574 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Insl3 mouse models; 1 with human INSL3 associations

Human Disease Mouse Models
      
IDs
View 5 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Targeted mutations that inactivate the locus result in abnormal gubernaculae development and consequent bilateral cryptorchidism. Spermatogenesis is impaired and male mice are infertile. Female infertility due to disregulation of the oestrus cycle was observed in one mutant line.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16336 NCBI Gene Model | MGI Sequence Detail 1326 C57BL/6J ±  kb
    transcript NM_013564 RefSeq | MGI Sequence Detail 587 C57BL/6  
    polypeptide O09107 UniProt | EBI | MGI Sequence Detail 122 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 2
      cDNA 9
      Primer pair 1
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-37470, MGI:1194923
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 25
      Diseases 2
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:33724 Pusch W, et al., Molecular cloning and expression of the relaxin-like factor from the mouse testis. Endocrinology. 1996 Jul;137(7):3009-13
    • Latest
      J:258670 Mahany EB, et al., Obesity and High-Fat Diet Induce Distinct Changes in Placental Gene Expression and Pregnancy Outcome. Endocrinology. 2018 Apr 1;159(4):1718-1733

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory