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Insl3
Gene Detail
 Symbol
Name
ID
Insl3
insulin-like 3
MGI:108427
Synonyms Ley I-L, Rlf, Rlnl
Feature Type protein coding gene
Genetic Map
Chromosome 8
34.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:71689214-71690575 bp, + strand
From VEGA annotation of GRCm38

  1362 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4048  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: insulin-like protein 3
Gene Tree: Insl3

Human
homologs
Human Homolog INSL3, insulin-like 3 (Leydig cell)
NCBI Gene ID 3640
neXtProt AC  NX_P51460
Human Synonyms  ley-I-L, RLF, RLNL
Human Chr (Location)  19p13.2-p12; chr19:17816513-17821574 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human INSL3
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
 
Targeted mutations that inactivate the locus result in abnormal gubernaculae development and consequent bilateral cryptorchidism. Spermatogenesis is impaired and male mice are infertile. Female infertility due to disregulation of the oestrus cycle was observed in one mutant line.
 
Human Diseases Modeled Using Mouse Insl3 (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Insl3 interacts with 20 markers (Mir92-2, Mir129-1, Mir129-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, in utero embryonic development, ...
Component extracellular region, extracellular space, ...
Function G-protein coupled receptor binding, hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (6)    Tissues (6)   
Theiler Stages: 22, 24, 26, 27
Assay TypeResults
RNA in situ 4
RNase protection 2
cDNA source data(9)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(12) Genomic(2) cDNA(9) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000021110 (Evidence)
Ensembl Gene ModelENSMUSG00000079019 (Evidence)
Entrez Gene16336 (Evidence)
DFCITC1630793
Consensus CDS ProjectCCDS22404.1
International Mouse Knockout Project StatusInsl3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021110 VEGA Gene Model | MGI Sequence Detail 1362 C57BL/6J ±  kb
transcript OTTMUST00000049959 VEGA | MGI Sequence Detail 623 Not Applicable 
polypeptide OTTMUSP00000023246 VEGA | MGI Sequence Detail 122 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(33 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022353 Insulin, conserved site
InterPro IPR022352 Insulin family
InterPro IPR016179 Insulin-like
Protein Ontology PR:000009058 insulin-like 3
References (Earliest) J:33724 Pusch W, et al., Molecular cloning and expression of the relaxin-like factor from the mouse testis. Endocrinology. 1996 Jul;137(7):3009-13
(Latest) J:197599 Pitetti JL, et al., Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice. PLoS Genet. 2013;9(1):e1003160
All references(54)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-37470, MGI:1194923

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory