Insl3
Gene Detail

Symbol Name ID

Insl3 insulin-like 3 MGI:108427

Synonyms

Ley I-L, Rlf, Rlnl

Feature Type

protein coding gene

Genetic Map

Chromosome 8

34.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr8:71689214-71690575 bp, + strand From VEGA annotation of GRCm38   1362 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4048  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: insulin-like protein 3
Gene Tree: Insl3

Human homologs

Human Homolog		INSL3, insulin-like 3 (Leydig cell)
NCBI Gene ID		3640
neXtProt AC		NX_P51460
Human Synonyms		ley-I-L, RLF, RLNL
Human Chr (Location)		19p13.2-p12; chr19:17927322-17932383 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human INSL3

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Targeted mutations that inactivate the locus result in abnormal gubernaculae development and consequent bilateral cryptorchidism. Spermatogenesis is impaired and male mice are infertile. Female infertility due to disregulation of the oestrus cycle was observed in one mutant line.

 
Human Diseases Modeled Using Mouse Insl3 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, in utero embryonic development, ...
Component	extracellular region, extracellular space, ...
Function	G-protein coupled receptor binding, hormone activity, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (6)    Tissues (6)   
Theiler Stages: 22, 24, 26, 28

Assay Type	Results
RNA in situ	4
RNase protection	2

cDNA source data(9)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(12) Genomic(2) cDNA(9) Other(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000021110 (Evidence)
Ensembl Gene Model	ENSMUSG00000079019 (Evidence)
Entrez Gene	16336 (Evidence)
DFCI	TC1630793
Consensus CDS Project	CCDS22404.1
International Mouse Knockout Project Status	Insl3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021110	VEGA Gene Model | MGI Sequence Detail	1362	C57BL/6J
transcript	OTTMUST00000049959	VEGA | MGI Sequence Detail	623	Not Applicable
polypeptide	OTTMUSP00000023246	VEGA | MGI Sequence Detail	122	Not Applicable

All sequences(18) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(9 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR022353	Insulin, conserved site
InterPro	IPR022352	Insulin family
InterPro	IPR016179	Insulin-like
Protein Ontology	PR:000009058	insulin-like 3

References

(Earliest) J:33724 Pusch W, et al., Molecular cloning and expression of the relaxin-like factor from the mouse testis. Endocrinology. 1996 Jul;137(7):3009-13
(Latest) J:192626 Miyado M, et al., Mamld1 deficiency significantly reduces mRNA expression levels of multiple genes expressed in mouse fetal Leydig cells but permits normal genital and reproductive development. Endocrinology. 2012 Dec;153(12):6033-40
All references(52)

Other accession IDs

MGD-MRK-37470, MGI:1194923