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Npy2r Gene Detail
Summary
  • Symbol
    Npy2r
  • Name
    neuropeptide Y receptor Y2
  • Synonyms
    NPY-Y2 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:108418
    NCBI Gene: 18167
  • Gene Overview
    MyGene.info: NPY2R
Location & Maps
more
  • Sequence Map
    Chr3:82538383-82548084 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9702 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 36.49 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    NPY2R, neuropeptide Y receptor Y2
  • Vertebrate Orthologs
    12
  • Human Ortholog
    NPY2R, neuropeptide Y receptor Y2
    Orthology source: HomoloGene
  • Synonyms
    NPY2-R
  • Links
    NCBI Gene ID: 4887
    neXtProt AC: NX_P49146

  • Chr Location
    4q31; chr4:155173754-155217096 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    52 phenotypes from 3 alleles in 6 genetic backgrounds
    43 phenotypes from multigenic genotypes
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Npy2r
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit reduced food intake, body weight, and adiposity, elevated plasma pancreatic polypeptide levels, increased cancellous bone volume, and heightened sensitivity to pentobarbital-induced sedation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043302 VEGA Gene Model | MGI Sequence Detail 9702 C57BL/6J ±  kb
transcript OTTMUST00000113601 VEGA | MGI Sequence Detail 3364 Not Applicable  
polypeptide OTTMUSP00000063502 VEGA | MGI Sequence Detail 381 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    105 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001493 neuropeptide Y receptor type 2
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR001358 Neuropeptide Y2 receptor
    IPR000611 Neuropeptide Y receptor family
Molecular
Reagents
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  • All nucleic 8
    Genomic 1
    cDNA 7

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-37461
References
more
  • Summaries
    All 93
    Developmental Gene Expression 7
    Gene Ontology 7
    Phenotypes 57
  • Earliest
    J:36684 Nakamura M, et al., Cloning and functional expression of a cDNA encoding a mouse type 2 neuropeptide Y receptor. Biochim Biophys Acta. 1996 Oct 23;1284(2):134-7
  • Latest
    J:223335 Chang RB, et al., Vagal Sensory Neuron Subtypes that Differentially Control Breathing. Cell. 2015 Apr 23;161(3):622-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory