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Npy2r Gene Detail
Summary
  • Symbol
    Npy2r
  • Name
    neuropeptide Y receptor Y2
  • Synonyms
    NPY-Y2 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:108418
    NCBI Gene: 18167
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:82445690-82455391 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 36.49 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    409 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108418
 protein coding gene Chr3:82445688-82455404 (-)
129S1/SvImJ ENSMUSG00200018833
 protein coding gene Chr3:79291838-79301552 (-)
A/J ENSMUSG00195011829
 protein coding gene Chr3:79298321-79308034 (-)
AKR/J ENSMUSG00220001292
 protein coding gene Chr3:79256235-79265887 (-)
BALB/cJ ENSMUSG00180001785
 protein coding gene Chr3:79429041-79438693 (-)
C3H/HeJ ENSMUSG00175007104
 protein coding gene Chr3:79225001-79234718 (-)
C57BL/6NJ ENSMUSG00215001912
 protein coding gene Chr3:79685724-79695425 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025100
 protein coding gene Chr3:75379455-75388967 (-)
CAST/EiJ ENSTCUG00005001537
 protein coding gene Chr3:78789734-78799444 (-)
CBA/J ENSMUSG00210025227
 protein coding gene Chr3:79355542-79365255 (-)
DBA/2J ENSMUSG00185012594
 protein coding gene Chr3:79513739-79523392 (-)
FVB/NJ ENSMUSG00205006255
 protein coding gene Chr3:78290645-78300346 (-)
JF1/MsJ ENSUMUG00000001171
 protein coding gene Chr3:79087956-79097553 (-)
LP/J ENSMUSG00230008213
 protein coding gene Chr3:81500383-81510093 (-)
NOD/ShiLtJ ENSMUSG00190002502
 protein coding gene Chr3:79751007-79760728 (-)
NZO/HlLtJ ENSMUSG00225005922
 protein coding gene Chr3:84231153-84240811 (-)
PWK/PhJ ENSLUMG00010006201
 protein coding gene Chr3:79132256-79141845 (-)
SPRET/EiJ ENSMSPG00010016324
 protein coding gene Chr3:79931774-79940322 (-)
WSB/EiJ ENSIUOG00005002968
 protein coding gene Chr3:79731018-79740685 (-)



Homology
more
  • Human Ortholog
    NPY2R, neuropeptide Y receptor Y2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPY2R, neuropeptide Y receptor Y2
  • Synonyms
    NPY2-R
  • Links
    NCBI Gene ID: 4887
    UniProt: P49146

  • Chr Location
    4q32.1; chr4:155173723-155217078 (+)  GRCh38
Human Diseases
more
  • Diseases
    7 with human NPY2R associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    57 phenotypes from 4 alleles in 7 genetic backgrounds
    43 phenotypes from multigenic genotypes
    83 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit reduced food intake, body weight, and adiposity, elevated plasma pancreatic polypeptide levels, increased cancellous bone volume, and heightened sensitivity to pentobarbital-induced sedation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    790
  • Tissues
    124
  • cDNA Data
    8
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028004 Ensembl Gene Model | MGI Sequence Detail 9702 C57BL/6J ±  kb
    transcript ENSMUST00000098997 Ensembl | MGI Sequence Detail 3325 Not Applicable  
    polypeptide ENSMUSP00000096595 Ensembl | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 1
      cDNA 8
      Other 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-37461
    References
    more
    • Summaries
      All 135
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 13
      Phenotypes 83
    • Earliest
      J:36684 Nakamura M, et al., Cloning and functional expression of a cDNA encoding a mouse type 2 neuropeptide Y receptor. Biochim Biophys Acta. 1996 Oct 23;1284(2):134-7
    • Latest
      J:389474 Liu Z, et al., Vagal blood volume receptors compensate for haemorrhage and posture change. Nature. 2026 Mar;651(8107):1068-1076
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory