About   Help   FAQ
Npy2r Gene Detail
Summary
  • Symbol
    Npy2r
  • Name
    neuropeptide Y receptor Y2
  • Synonyms
    NPY-Y2 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:108418
    NCBI Gene: 18167
  • Gene Overview
    MyGene.info: NPY2R
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:82538383-82548084 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 36.49 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    105 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108418
protein coding gene Chr3:82538383-82548989 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027328
protein coding gene Chr3:82349029-82358739 (-)
A/J MGP_AJ_G0027290
protein coding gene Chr3:79627969-79638680 (-)
AKR/J MGP_AKRJ_G0027258
protein coding gene Chr3:81520639-81530291 (-)
BALB/cJ MGP_BALBcJ_G0027301
protein coding gene Chr3:79721663-79731315 (-)
C3H/HeJ MGP_C3HHeJ_G0027045
protein coding gene Chr3:81798585-81808298 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027747
protein coding gene Chr3:85454099-85463800 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025100
protein coding gene Chr3:75379455-75388967 (-)
CAST/EiJ MGP_CASTEiJ_G0026492
protein coding gene Chr3:81992192-82005180 (-)
CBA/J MGP_CBAJ_G0027020
protein coding gene Chr3:88341865-88351578 (-)
DBA/2J MGP_DBA2J_G0027156
protein coding gene Chr3:79186478-79196143 (-)
FVB/NJ MGP_FVBNJ_G0027124
protein coding gene Chr3:77463737-77473520 (-)
LP/J MGP_LPJ_G0027264
protein coding gene Chr3:83341125-83351246 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027143
protein coding gene Chr3:94726144-94736233 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027805
protein coding gene Chr3:81323996-81333658 (-)
PWK/PhJ MGP_PWKPhJ_G0026226
protein coding gene Chr3:78923335-78933080 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026042
protein coding gene Chr3:80516700-80525280 (-)
WSB/EiJ MGP_WSBEiJ_G0026570
protein coding gene Chr3:81657475-81667142 (-)



Homology
more
  • Human Ortholog
    NPY2R, neuropeptide Y receptor Y2
  • Vertebrate Orthologs
    12
  • Human Ortholog
    NPY2R, neuropeptide Y receptor Y2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NPY2-R
  • Links
    NCBI Gene ID: 4887
    neXtProt AC: NX_P49146
    UniProt: P49146

  • Chr Location
    4q32.1; chr4:155173514-155217078 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    52 phenotypes from 3 alleles in 6 genetic backgrounds
    43 phenotypes from multigenic genotypes
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit reduced food intake, body weight, and adiposity, elevated plasma pancreatic polypeptide levels, increased cancellous bone volume, and heightened sensitivity to pentobarbital-induced sedation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028004 Ensembl Gene Model | MGI Sequence Detail 9702 C57BL/6J ±  kb
    transcript ENSMUST00000182831 Ensembl | MGI Sequence Detail 1689 Not Applicable  
    polypeptide ENSMUSP00000138282 Ensembl | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 1
      cDNA 8
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-37461
    References
    more
    • Summaries
      All 99
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 6
      Phenotypes 58
    • Earliest
      J:36684 Nakamura M, et al., Cloning and functional expression of a cDNA encoding a mouse type 2 neuropeptide Y receptor. Biochim Biophys Acta. 1996 Oct 23;1284(2):134-7
    • Latest
      J:242690 Qi L, et al., Hierarchical Specification of Pruriceptors by Runt-Domain Transcription Factor Runx1. J Neurosci. 2017 May 31;37(22):5549-5561

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory