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Ripk1
Gene Detail
Symbol

Name
ID
Ripk1
receptor (TNFRSF)-interacting serine-threonine kinase 1
MGI:108212
Synonyms
Rinp, Rip1
Feature Type
protein coding gene
Genetic Map
Chromosome 13
14.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:34002363-34035170 bp, + strand
From VEGA annotation of GRCm38

  32808 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2820  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ripk1

Human
homologs
Human Homolog RIPK1, receptor (TNFRSF)-interacting serine-threonine kinase 1
NCBI Gene ID 8737
neXtProt AC  NX_Q13546
Human Synonyms  RIP, RIP1
Human Chr (Location)  6p25.2; chr6:3063967-3115187 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene die within 1 and 3 days of birth displaying extensive apoptosis in both lymphoid and adipose tissue.
 
Interactions
Ripk1 interacts with 283 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (85 annotations)
Process amyloid fibril formation, apoptotic process, ...
Component cytoplasm, death-inducing signaling complex, ...
Function ATP binding, death domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (24)    Tissues (15)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000035489 (Evidence)
Ensembl Gene ModelENSMUSG00000021408 (Evidence)
Entrez Gene19766 (Evidence)
DFCITC1579735, TC1604029, TC1617668
DoTSDT.91382139, DT.91356790, DT.101355158, DT.483856
NIA Mouse Gene IndexU014717
EC2.7.11.1
Consensus CDS ProjectCCDS26443.1
International Mouse Knockout Project StatusRipk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035489 VEGA Gene Model | MGI Sequence Detail 32808 C57BL/6J ±  kb
transcript OTTMUST00000090874 VEGA | MGI Sequence Detail 4495 Not Applicable 
polypeptide OTTMUSP00000049968 VEGA | MGI Sequence Detail 656 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(251 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR025735 RHIM domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology PR:000014022 receptor-interacting serine/threonine-protein kinase 1
References
(Earliest) J:43377 Stanger BZ, et al., RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell. 1995 May 19;81(4):513-23
(Latest) J:214394 Rickard JA, et al., RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis. Cell. 2014 May 22;157(5):1175-88
All references(78)
Other
accession IDs
MGD-MRK-37251

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory