Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 8.1.0)

Enables protein homodimerization activity; protein serine/threonine kinase activity; and signaling adaptor activity. Involved in several processes, including necroptotic signaling pathway; negative regulation of necroptotic process; and regulation of signal transduction. Acts upstream of or within several processes, including negative regulation of canonical NF-kappaB signal transduction; regulation of extrinsic apoptotic signaling pathway; and ripoptosome assembly involved in necroptotic process. Predicted to be located in mitochondrion. Predicted to be part of death-inducing signaling complex; receptor complex; and ripoptosome. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; immune system; limb; liver; and lung. Human ortholog(s) of this gene implicated in immunodeficiency 57. Orthologous to human RIPK1 (receptor interacting serine/threonine kinase 1).

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Gene Ontology Evidence Code Abbreviations:

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