Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables protein homodimerization activity; protein serine/threonine kinase activity; and signaling adaptor activity. Involved in several processes, including necroptotic signaling pathway; negative regulation of necroptotic process; and regulation of signal transduction. Acts upstream of or within regulation of extrinsic apoptotic signaling pathway; regulation of reactive oxygen species metabolic process; and ripoptosome assembly involved in necroptotic process. Predicted to be located in mitochondrion. Predicted to be part of death-inducing signaling complex; receptor complex; and ripoptosome. Is expressed in several structures, including central nervous system; immune system; limb; liver; and lung. Human ortholog(s) of this gene implicated in immunodeficiency 57. Orthologous to human RIPK1 (receptor interacting serine/threonine kinase 1).