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Ywhag
Gene Detail
Symbol

Name
ID
Ywhag
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
MGI:108109
Synonyms
14-3-3 gamma, D7Bwg1348e
Feature Type
protein coding gene
Genetic Map
Chromosome 5
75.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:135908409-135934616 bp, - strand
From VEGA annotation of GRCm38

  26208 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22725  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: 14-3-3 protein
Gene Tree: Ywhag

Human
homologs
Human Homolog YWHAG, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
NCBI Gene ID 7532
neXtProt AC  NX_P61981
Human Synonyms  14-3-3GAMMA, PPP1R170
Human Chr (Location)  7q11.23; chr7:76326791-76359025 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(79) : Gene trapped(75) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants appear normal and exhibit unchanged survival rates after inoculation with pathological prion protein.
 
Interactions
Ywhag interacts with 313 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cellular response to insulin stimulus, oxidation-reduction process, ...
Component cell, cytoplasm, ...
Function insulin-like growth factor receptor binding, monooxygenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (135)    Tissues (123)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 135
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000016297 (Evidence)
Ensembl Gene ModelENSMUSG00000051391 (Evidence)
Entrez Gene22628 (Evidence)
DFCITC1573211, TC1591488, TC1609195, TC1663697, TC1695534
DoTSDT.101299985, DT.101406692, DT.55171034, DT.91558992, DT.94198055, DT.97352003
NIA Mouse Gene IndexU026827
Consensus CDS ProjectCCDS19748.1
International Mouse Knockout Project StatusYwhag
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016297 VEGA Gene Model | MGI Sequence Detail 26208 C57BL/6J ±  kb
transcript OTTMUST00000039163 VEGA | MGI Sequence Detail 3520 Not Applicable 
polypeptide OTTMUSP00000017492 VEGA | MGI Sequence Detail 247 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(58 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023410 14-3-3 domain
InterPro IPR000308 14-3-3 protein
InterPro IPR023409 14-3-3 protein, conserved site
Protein Ontology PR:000017550 14-3-3 protein gamma
References
(Earliest) J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
(Latest) J:205129 Li G, et al., Combinatorial H3K9acS10ph histone modification in IgH locus S regions targets 14-3-3 adaptors and AID to specify antibody class-switch DNA recombination. Cell Rep. 2013 Nov 14;5(3):702-14
All references(53)
Other
accession IDs
MGD-MRK-34146, MGD-MRK-37146, MGI:106452

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory