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Ywhag
Gene Detail
Symbol

Name
ID
Ywhag
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
MGI:108109
Synonyms
14-3-3 gamma, D7Bwg1348e
Feature Type
protein coding gene
Genetic Map
Chromosome 5
75.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:135908409-135934616 bp, - strand
From VEGA annotation of GRCm38

  26208 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22725  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: YWHAG
Protein SuperFamily: 14-3-3 protein
Gene Tree: Ywhag

Human
homologs
YWHAG, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7532
neXtProt AC: NX_P61981

Human Synonyms: 14-3-3GAMMA, PPP1R170

Human Chr (Location): 7q11.23; chr7:76326791-76359025 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(64) : Gene trapped(60) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants appear normal and exhibit unchanged survival rates after inoculation with pathological prion protein.
 
Interactions
Ywhag interacts with 313 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cellular response to insulin stimulus, protein targeting, ...
Component cytoplasm, extracellular exosome, ...
Function insulin-like growth factor receptor binding, poly(A) RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (135)    Tissues (123)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 135
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ywhag    NEW 
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000016297 (Evidence)
Ensembl Gene Model ENSMUSG00000051391 (Evidence)
Entrez Gene 22628 (Evidence)
DFCI TC1663697, TC1609195, TC1591488, TC1573211, TC1695534
DoTS DT.101299985, DT.91558992, DT.55171034, DT.101406692, DT.94198055, DT.97352003
NIA Mouse Gene Index U026827
Consensus CDS Project CCDS19748.1
International Mouse Phenotyping Consortium Status Ywhag
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016297 VEGA Gene Model | MGI Sequence Detail 26208 C57BL/6J ±  kb
transcript OTTMUST00000039163 VEGA | MGI Sequence Detail 3520 Not Applicable 
polypeptide OTTMUSP00000017492 VEGA | MGI Sequence Detail 247 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(58 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023410 14-3-3 domain
InterPro IPR000308 14-3-3 protein
InterPro IPR023409 14-3-3 protein, conserved site
Protein Ontology PR:000017550 14-3-3 protein gamma
References
(Earliest) J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
(Latest) J:213183 Sehgal L, et al., 14-3-3gamma-Mediated transport of plakoglobin to the cell border is required for the initiation of desmosome assembly in vitro and in vivo. J Cell Sci. 2014 May 15;127(Pt 10):2174-88
All references(53)
Other
accession IDs
MGD-MRK-34146, MGD-MRK-37146, MGI:106452

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory