Ywhag MGI Mouse Gene Detail - MGI:108109 - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide

Symbol

Ywhag
Name

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
Synonyms

14-3-3 gamma, D7Bwg1348e

Feature Type

protein coding gene
IDs

MGI:108109
NCBI Gene: 22628
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr5:135937263-135963470 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 75.53 cM
Mapping Data

1 experiment

SNPs within 2kb

58 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108109	protein coding gene	Chr5:135937233-135963495 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030193	protein coding gene	Chr5:140508210-140538336 (-)
A/J	MGP_AJ_G0030161	protein coding gene	Chr5:134468616-134494523 (-)
AKR/J	MGP_AKRJ_G0030094	protein coding gene	Chr5:138815425-138843039 (-)
BALB/cJ	MGP_BALBcJ_G0030171	protein coding gene	Chr5:135820185-135850070 (-)
C3H/HeJ	MGP_C3HHeJ_G0029887	protein coding gene	Chr5:139419747-139447453 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030624	protein coding gene	Chr5:145743847-145770592 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027846	protein coding gene	Chr5:128754943-128781837 (-)
CAST/EiJ	MGP_CASTEiJ_G0029297	protein coding gene	Chr5:138824783-138852060 (-)
CBA/J	MGP_CBAJ_G0029857	protein coding gene	Chr5:151397386-151432758 (-)
DBA/2J	MGP_DBA2J_G0030008	protein coding gene	Chr5:134366103-134391869 (-)
FVB/NJ	MGP_FVBNJ_G0029963	protein coding gene	Chr5:133513919-133542050 (-)
LP/J	MGP_LPJ_G0030097	protein coding gene	Chr5:140933023-140960604 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029995	protein coding gene	Chr5:154415867-154442654 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030664	protein coding gene	Chr5:138610850-138640076 (-)
PWK/PhJ	MGP_PWKPhJ_G0029010	protein coding gene	Chr5:133425795-133452491 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028846	protein coding gene	Chr5:136161926-136188126 (-)
WSB/EiJ	MGP_WSBEiJ_G0029370	protein coding gene	Chr5:139341868-139368027 (-)

Human Ortholog

YWHAG, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

YWHAG, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
Synonyms

14-3-3GAMMA, DEE56, EIEE56, PPP1R170
Links

HGNC:12852

NCBI Gene ID: 7532

neXtProt AC: NX_P61981

UniProt: P61981
Chr Location

7q11.23; chr7:76326799-76358991 (-) GRCh38

MGI Vertebrate Homology

Ywhag stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: YWHAG
Protein SuperFamily

14-3-3
Gene Tree

Ywhag

Diseases

1 with human YWHAG associations

				Human Disease	Mouse Models
				developmental and epileptic encephalopathy 56 IDs developmental and epileptic encephalopathy 56 DOID:0080282 OMIM:617665

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
17 phenotype references

All Mutations and Alleles

59
Endonuclease-mediated

1
Gene trapped

54
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available

Homozygous null mutants appear normal and exhibit unchanged survival rates after inoculation with pathological prion protein.

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All GO Annotations

33
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

844
Tissues

126
cDNA Data

13
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ywhag

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All Sequences

67
RefSeq

2
UniProt

3
CCDS

CCDS19748.1

Ensembl

ENSMUSG00000051391 (Evidence)
NCBI Gene

22628

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051391	Ensembl Gene Model \| MGI Sequence Detail	26208	C57BL/6J	± kb
transcript	ENSMUST00000055808	Ensembl \| MGI Sequence Detail	3520	Not Applicable
polypeptide	ENSMUSP00000051223	Ensembl \| MGI Sequence Detail	247	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000017550 14-3-3 protein gamma

(term hierarchy)
InterPro Domains

IPR023410 14-3-3 domain

IPR036815 14-3-3 domain superfamily

IPR000308 14-3-3 protein

IPR023409 14-3-3 protein, conserved site

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All nucleic 16

cDNA 13

Primer pair 2

Other 1

Microarray probesets 7

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MGD-MRK-34146, MGD-MRK-37146, MGI:106452

Summaries

All 66

Developmental Gene Expression 6

Gene Ontology 10

Phenotypes 17
Earliest

J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
Latest

J:333922 Cho E, et al., 14-3-3gamma haploinsufficiency leads to altered dopamine pathway and Parkinson's disease-like motor incoordination in mice. Mol Brain. 2023 Jan 5;16(1):2

TSS for Ywhag:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr53782	Chr5:135963473-135963487 (-)	-10 bp
Tssr53781	Chr5:135963444-135963467 (-)	14 bp
Tssr53780	Chr5:135963411-135963422 (-)	53 bp
Tssr53778	Chr5:135940424-135940437 (-)	23,039 bp
Tssr53777	Chr5:135940400-135940412 (-)	23,064 bp
Tssr53776	Chr5:135940327-135940338 (-)	23,137 bp
Tssr53775	Chr5:135940302-135940320 (-)	23,159 bp
Tssr53774	Chr5:135940200-135940214 (-)	23,263 bp
Tssr53773	Chr5:135940158-135940176 (-)	23,303 bp
Tssr53772	Chr5:135939742-135939766 (-)	23,716 bp
Tssr53771	Chr5:135939724-135939741 (-)	23,737 bp
Tssr53770	Chr5:135939635-135939648 (-)	23,828 bp
Tssr53769	Chr5:135939535-135939546 (-)	23,929 bp
Tssr53768	Chr5:135939472-135939509 (-)	23,979 bp
Tssr53767	Chr5:135939434-135939452 (-)	24,027 bp
Tssr53766	Chr5:135938994-135939020 (-)	24,463 bp
Tssr53765	Chr5:135938325-135938340 (-)	25,137 bp
Tssr53764	Chr5:135938088-135938104 (-)	25,374 bp
Tssr53763	Chr5:135937742-135937860 (-)	25,669 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23