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Dvl3
Gene Detail
 Symbol
Name
ID
Dvl3
dishevelled 3, dsh homolog (Drosophila)
MGI:108100
Feature Type protein coding gene
Genetic Map
Chromosome 16
12.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:20516982-20532520 bp, + strand
From VEGA annotation of GRCm38

  15539 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20928  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: segment polarity protein dishevelled homolog DVL
Gene Tree: Dvl3

Human
homologs
Human Homolog DVL3, dishevelled segment polarity protein 3
NCBI Gene ID 1857
neXtProt AC  NX_Q92997
Human Chr (Location)  3q27; chr3:184155311-184173526 (+)  GRCh38
Alleles
and
phenotypes
All alleles(8) : Gene trapped(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit postnatal lethality associated with respiratory distress, persistent truncus arteriosis, and double outlet right ventricle.
 
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process canonical Wnt signaling pathway, cochlea morphogenesis, ...
Component cell cortex, cytoplasm
Function beta-catenin binding, frizzled binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (235)    Tissues (148)    Images (27)
Theiler Stages: 1, 2, 3, 4, 5, 17, 20, 22, 23, 25, 28
Assay TypeResults
RNA in situ 172
RT-PCR 63
cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(19) Genomic(2) cDNA(9) Primer pair(6) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035778 (Evidence)
Ensembl Gene ModelENSMUSG00000003233 (Evidence)
Entrez Gene13544 (Evidence)
DFCITC1588186, TC1629155, TC1721712
DoTSDT.101725079, DT.110721160, DT.87048903, DT.87065777
NIA Mouse Gene IndexU016917
Consensus CDS ProjectCCDS37287.1
International Mouse Knockout Project StatusDvl3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035778 VEGA Gene Model | MGI Sequence Detail 15539 C57BL/6J ±  kb
transcript OTTMUST00000091557 VEGA | MGI Sequence Detail 2493 Not Applicable 
polypeptide OTTMUSP00000050444 VEGA | MGI Sequence Detail 718 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(12) UniProt(4)
Polymorphisms SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000591 DEP domain
InterPro IPR008342 Dishevelled-3
InterPro IPR024580 Dishevelled C-terminal
InterPro IPR008339 Dishevelled family
InterPro IPR003351 Dishevelled protein domain
InterPro IPR015506 Dishevelled-related protein
InterPro IPR001158 DIX domain
InterPro IPR001478 PDZ domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000006768 segment polarity protein dishevelled DVL-3
References (Earliest) J:36588 Tsang M, et al., Isolation and characterization of mouse dishevelled-3. Dev Dyn. 1996 Nov;207(3):253-62
(Latest) J:194976 Huang X, et al., Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling. Science. 2013 Mar 22;339(6126):1441-5
All references(58)
Other
accession IDs
MGD-MRK-37137

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory