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Hars Gene Detail
Summary
  • Symbol
    Hars
  • Name
    histidyl-tRNA synthetase
  • Synonyms
    MMHRS
  • Feature Type
    protein coding gene
  • IDs
    MGI:108087
    NCBI Gene: 15115
  • Gene Overview
    MyGene.info: HARS
Location & Maps
more
  • Sequence Map
    Chr18:36766530-36783205 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16676 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 19.46 cM, cytoband B3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HARS, histidyl-tRNA synthetase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HARS, histidyl-tRNA synthetase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CMT2W, HRS, USH3B
  • Links
    NCBI Gene ID: 3035
    neXtProt AC: NX_P12081

  • Chr Location
    5q31.3; chr5:140673904-140691727 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human HARS associations

Human Disease Mouse Models
       Charcot-Marie-Tooth Disease, Axonal, Type 2w; CMT2W   OMIM: 616625
Usher Syndrome, Type IIIB; USH3B   OMIM: 614504
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    6
  • Gene trapped
    4
  • Targeted
    2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001380 Ensembl Gene Model | MGI Sequence Detail 16676 C57BL/6J ±  kb
transcript ENSMUST00000001416 Ensembl | MGI Sequence Detail 1987 Not Applicable  
polypeptide ENSMUSP00000001416 Ensembl | MGI Sequence Detail 509 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    92 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 141
    cDNA 140
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-37124
References
more
  • Summaries
    All 30
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:36427 Blechynden LM, et al., Sequence and polymorphism analysis of the murine gene encoding histidyl-tRNA synthetase. Gene. 1996 Oct 31;178(1-2):151-6
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory