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Hars
Gene Detail
 Symbol
Name
ID
Hars
histidyl-tRNA synthetase
MGI:108087
Synonyms MMHRS
Feature Type protein coding gene
Genetic Map
Chromosome 18
19.46 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:36766530-36783205 bp, - strand
From Ensembl annotation of GRCm38

  16676 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1592  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: histidyl-tRNA synthetase
Gene Tree: Hars

Human
homologs
Human Homolog HARS, histidyl-tRNA synthetase
NCBI Gene ID 3035
neXtProt AC  NX_P12081
Human Synonyms  HRS, USH3B
Human Chr (Location)  5q31.3; chr5:140673904-140691727 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human HARS
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(4) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Hars interacts with 79 markers (Mir1b, Mir7-1, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process histidyl-tRNA aminoacylation, translation, ...
Component cytoplasm
Function aminoacyl-tRNA ligase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (175)    Tissues (146)    Images (31)
Theiler Stages: 22, 23, 28
Assay TypeResults
RNA in situ 129
RT-PCR 46
cDNA source data(139)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(141) cDNA(140) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000001380 (Evidence)
Entrez Gene15115 (Evidence)
UniGene10528
DFCITC1572258, TC1682683, TC1754709
DoTSDT.101218963, DT.97359118
NIA Mouse Gene IndexU038344
EC6.1.1.21
Consensus CDS ProjectCCDS29164.1
International Mouse Knockout Project StatusHars
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001380 Ensembl Gene Model | MGI Sequence Detail 16676 C57BL/6J ±  kb
transcript ENSMUST00000001416 Ensembl | MGI Sequence Detail 1987 Not Applicable 
polypeptide ENSMUSP00000001416 Ensembl | MGI Sequence Detail 509 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(6)
Polymorphisms SNPs within 2kb(92 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006195 Aminoacyl-tRNA synthetase, class II
InterPro IPR004154 Anticodon-binding
InterPro IPR015807 Histidine-tRNA ligase
InterPro IPR004516 Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit
InterPro IPR009068 S15/NS1, RNA-binding
InterPro IPR000738 WHEP-TRS
Protein Ontology PR:000008448 histidyl-tRNA synthetase, cytoplasmic
References (Earliest) J:36427 Blechynden LM, et al., Sequence and polymorphism analysis of the murine gene encoding histidyl-tRNA synthetase. Gene. 1996 Oct 31;178(1-2):151-6
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(35)
Other
accession IDs
MGD-MRK-37124

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory