Automated description from the Alliance of Genome Resources (Release 5.3.0)
Predicted to enable ATP binding activity; histidine-tRNA ligase activity; and protein homodimerization activity. Predicted to be involved in histidyl-tRNA aminoacylation and mitochondrial translation. Predicted to act upstream of or within translation. Predicted to be located in cytoplasm. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease, axonal type 2W and Usher syndrome type 3B. Orthologous to human HARS1 (histidyl-tRNA synthetase 1).