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Hpgd
Gene Detail
Symbol

Name
ID
Hpgd
hydroxyprostaglandin dehydrogenase 15 (NAD)
MGI:108085
Synonyms
15-PGDH
Feature Type
protein coding gene
Genetic Map
Chromosome 8
29.70 cM, cytoband B3.2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:56294552-56321046 bp, + strand
From NCBI annotation of GRCm38

  26495 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68095  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HPGD
Gene Tree: Hpgd

Human
homologs
HPGD, hydroxyprostaglandin dehydrogenase 15-(NAD)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3248
neXtProt AC: NX_P15428

Human Synonyms: 15-PGDH, PGDH, PGDH1, PHOAR1, SDR36C1

Human Chr (Location): 4q34-q35; chr4:174490177-174522898 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human HPGD

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results failure of the ductus arteriosus to close and perinatal lethality. Mutant animals die within 12-48 hours after birth due to congestive heart failure. Mice homozygous for a hypomorphic allele exhibit preterm labor.
 
Human Diseases Modeled in Mice Using Hpgd (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Hpgd interacts with 180 markers (Mir1a-1, Mir1a-2, Mir15b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (9 records)
Data Summary: Results (193)    Tissues (156)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 191
RT-PCR 2
cDNA source data(63)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hpgd    NEW 
Molecular
reagents
All nucleic(65) cDNA(64) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000031613 (Evidence)
Entrez Gene 15446 (Evidence)
UniGene 18832
DFCI TC1576847
DoTS DT.493434, DT.110869440
NIA Mouse Gene Index U009349
EC 1.1.1.141
Consensus CDS Project CCDS40341.1
International Mouse Phenotyping Consortium Status Hpgd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 15446 NCBI Gene Model | MGI Sequence Detail 26495 C57BL/6J ±  kb
transcript NM_008278 RefSeq | MGI Sequence Detail 1719 C57BL/6 
polypeptide Q8VCC1 UniProt | EBI | MGI Sequence Detail 269 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(309 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR020904 Short-chain dehydrogenase/reductase, conserved site
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
Protein Ontology PR:000008732 15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Graphical View of Protein Domain Structure
References
(Earliest) J:36774 Matsuo M, et al., Cloning and expression of the cDNA for mouse NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase. Biochim Biophys Acta. 1996 Nov 11;1309(1-2):21-4
(Latest) J:219833 Fink SP, et al., Sulindac reversal of 15-PGDH-mediated resistance to colon tumor chemoprevention with NSAIDs. Carcinogenesis. 2015 Feb;36(2):291-8
All references(45)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-37122, MGI:2142735

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory