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Hpgd Gene Detail
Summary
  • Symbol
    Hpgd
  • Name
    hydroxyprostaglandin dehydrogenase 15 (NAD)
  • Synonyms
    15-PGDH
  • Feature Type
    protein coding gene
  • IDs
    MGI:108085
    NCBI Gene: 15446
  • Gene Overview
    MyGene.info: HPGD
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:56294585-56321043 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 29.70 cM, cytoband B3.2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    308 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108085
protein coding gene Chr8:56294552-56321046 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033618
protein coding gene Chr8:55983754-56010982 (+)
A/J MGP_AJ_G0033600
protein coding gene Chr8:53632403-53659238 (+)
AKR/J MGP_AKRJ_G0033525
protein coding gene Chr8:55222393-55248916 (+)
BALB/cJ MGP_BALBcJ_G0033597
protein coding gene Chr8:53952088-53979052 (+)
C3H/HeJ MGP_C3HHeJ_G0033306
protein coding gene Chr8:55905264-55932068 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034113
protein coding gene Chr8:58120319-58149871 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031061
protein coding gene Chr8:49265321-49293293 (+)
CAST/EiJ MGP_CASTEiJ_G0032632
protein coding gene Chr8:55271611-55298316 (+)
CBA/J MGP_CBAJ_G0033285
protein coding gene Chr8:60175783-60203248 (+)
DBA/2J MGP_DBA2J_G0033438
protein coding gene Chr8:53465447-53491777 (+)
FVB/NJ MGP_FVBNJ_G0033379
protein coding gene Chr8:52831503-52858028 (+)
LP/J MGP_LPJ_G0033526
protein coding gene Chr8:56001935-56031939 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033423
protein coding gene Chr8:61752046-61780734 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034131
protein coding gene Chr8:55471358-55498787 (+)
PWK/PhJ MGP_PWKPhJ_G0032340
protein coding gene Chr8:52782387-52812262 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032176
protein coding gene Chr8:54371167-54398526 (+)
WSB/EiJ MGP_WSBEiJ_G0032748
protein coding gene Chr8:55678011-55705299 (+)



Homology
more
  • Human Ortholog
    HPGD, 15-hydroxyprostaglandin dehydrogenase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HPGD, 15-hydroxyprostaglandin dehydrogenase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    15-PGDH, PGDH, PGDH1, PHOAR1, SDR36C1
  • Links
    NCBI Gene ID: 3248
    neXtProt AC: NX_P15428
    UniProt: P15428

  • Chr Location
    4q34.1; chr4:174490177-174522898 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 68095
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HPGD
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human HPGD associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results failure of the ductus arteriosus to close and perinatal lethality. Mutant animals die within 12-48 hours after birth due to congestive heart failure. Mice homozygous for a hypomorphic allele exhibit preterm labor.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031613 Ensembl Gene Model | MGI Sequence Detail 26459 C57BL/6J ±  kb
    transcript ENSMUST00000034026 Ensembl | MGI Sequence Detail 1683 Not Applicable  
    polypeptide ENSMUSP00000034026 Ensembl | MGI Sequence Detail 269 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 67
      cDNA 66
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-37122, MGI:2142735
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:36774 Matsuo M, et al., Cloning and expression of the cDNA for mouse NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase. Biochim Biophys Acta. 1996 Nov 11;1309(1-2):21-4
    • Latest
      J:246134 Yao L, et al., 15-hydroxyprostaglandin dehydrogenase (15-PGDH) prevents lipopolysaccharide (LPS)-induced acute liver injury. PLoS One. 2017;12(4):e0176106

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory