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Hpgd Gene Detail
Summary
  • Symbol
    Hpgd
  • Name
    hydroxyprostaglandin dehydrogenase 15 (NAD)
  • Synonyms
    15-PGDH
  • Feature Type
    protein coding gene
  • IDs
    MGI:108085
    NCBI Gene: 15446
  • Gene Overview
    MyGene.info: HPGD
Location & Maps
more
  • Sequence Map
    Chr8:56294585-56321043 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26459 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 29.70 cM, cytoband B3.2
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    HPGD, hydroxyprostaglandin dehydrogenase 15-(NAD)
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HPGD, hydroxyprostaglandin dehydrogenase 15-(NAD)
    Orthology source: HomoloGene, HGNC
  • Synonyms
    15-PGDH, PGDH, PGDH1, PHOAR1, SDR36C1
  • Links
    NCBI Gene ID: 3248
    neXtProt AC: NX_P15428

  • Chr Location
    4q34-q35; chr4:174490177-174522898 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 68095
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: HPGD
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human HPGD associations

Human Disease Mouse Models
       Digital Clubbing, Isolated Congenital   OMIM: 119900
Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1; PHOAR1   OMIM: 259100
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Hpgd
  • Incidental Mutations
Homozygous mutation of this gene results failure of the ductus arteriosus to close and perinatal lethality. Mutant animals die within 12-48 hours after birth due to congestive heart failure. Mice homozygous for a hypomorphic allele exhibit preterm labor.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000060690 VEGA Gene Model | MGI Sequence Detail 26459 C57BL/6J ±  kb
transcript OTTMUST00000148393 VEGA | MGI Sequence Detail 1683 Not Applicable  
polypeptide OTTMUSP00000077148 VEGA | MGI Sequence Detail 269 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    308 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000008732 15-hydroxyprostaglandin dehydrogenase [NAD(+)]
  • EC
  • InterPro Domains
    IPR016040 NAD(P)-binding domain
    IPR020904 Short-chain dehydrogenase/reductase, conserved site
    IPR002347 Short-chain dehydrogenase/reductase SDR
Molecular
Reagents
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  • All nucleic 65
    cDNA 64
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-37122, MGI:2142735
References
more
  • Summaries
    All 45
    Developmental Gene Expression 9
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:36774 Matsuo M, et al., Cloning and expression of the cDNA for mouse NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase. Biochim Biophys Acta. 1996 Nov 11;1309(1-2):21-4
  • Latest
    J:224757 Zhang Y, et al., TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. Science. 2015 Jun 12;348(6240):aaa2340

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory