Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity. Involved in ductus arteriosus closure. Located in basolateral plasma membrane. Is expressed in several structures, including alimentary system; choroid plexus; genitourinary system; humerus cartilage condensation; and nose. Human ortholog(s) of this gene implicated in colon carcinoma and primary hypertrophic osteoarthropathy. Orthologous to human HPGD (15-hydroxyprostaglandin dehydrogenase).