Serpinf1
Gene Detail

Symbol Name ID

Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 MGI:108080

Synonyms

EPC-1, Pedf, Pedfl, pigment epithelium derived factor, Sdf3

Feature Type

protein coding gene

Genetic Map

Chromosome 11

45.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:75409769-75422701 bp, - strand From VEGA annotation of GRCm38   12933 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1965  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: serpin
Gene Tree: Serpinf1

Human homologs

Human Homolog		SERPINF1, serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
NCBI Gene ID		5176
neXtProt AC		NX_P36955
Human Synonyms		EPC-1, OI12, OI6, PEDF
Human Chr (Location)		17p13.3; chr17:1665259-1680859 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SERPINF1

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Loss of function results in increased microvasculature, pancreatic enlargement, and prostatic hyperplasia.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	negative regulation of angiogenesis, negative regulation of endopeptidase activity, ...
Component	extracellular matrix, extracellular region, ...
Function	serine-type endopeptidase inhibitor activity

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (380)    Tissues (148)    Images (43)
Theiler Stages: 7, 18, 19, 20, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	372
Northern blot	8

cDNA source data(270)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(274) cDNA(273) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000006203 (Evidence)
Ensembl Gene Model	ENSMUSG00000000753 (Evidence)
Entrez Gene	20317 (Evidence)
UniGene	2044
DFCI	TC1572018, TC1628078
DoTS	DT.496684, DT.99858581
NIA Mouse Gene Index	U033077
Consensus CDS Project	CCDS25045.1
International Mouse Knockout Project Status	Serpinf1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006203	VEGA Gene Model | MGI Sequence Detail	12933	C57BL/6J
transcript	OTTMUST00000013988	VEGA | MGI Sequence Detail	1832	Not Applicable
polypeptide	OTTMUSP00000006497	VEGA | MGI Sequence Detail	417	Not Applicable

All sequences(59) RefSeq(2) UniProt(8)

Polymorphisms

SNPs(81 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023795	Protease inhibitor I4, serpin, conserved site
InterPro	IPR023796	Serpin domain
InterPro	IPR000215	Serpin family
Protein Ontology	PR:000014705	pigment epithelium-derived factor

References

(Earliest) J:22201 Pignolo RJ, et al., Analysis of EPC-1 growth state-dependent expression, specificity, and conservation of related sequences. J Cell Physiol. 1995 Jan;162(1):110-8
(Latest) J:181974 Seo S, et al., Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2015-20
All references(48)

Other accession IDs

MGD-MRK-23945, MGD-MRK-37117, MGI:103081, MGI:2144083