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Serpinf1
Gene Detail
Symbol

Name
ID
Serpinf1
serine (or cysteine) peptidase inhibitor, clade F, member 1
MGI:108080
Synonyms
alpha-2 antiplasmin, EPC-1, Pedf, Pedfl, pigment epithelium derived factor, Sdf3
Feature Type
protein coding gene
Genetic Map
Chromosome 11
45.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:75409769-75422701 bp, - strand
From VEGA annotation of GRCm38

  12933 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1965  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: serpin
Gene Tree: Serpinf1

Human
homologs
Human Homolog SERPINF1, serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
NCBI Gene ID 5176
neXtProt AC  NX_P36955
Human Synonyms  EPC-1, OI12, OI6, PEDF
Human Chr (Location)  17p13.3; chr17:1761965-1777565 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SERPINF1
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Loss of function results in increased microvasculature, pancreatic enlargement, and prostatic hyperplasia.
 
Interactions
Serpinf1 interacts with 125 markers (Mir1a-1, Mir1a-2, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process negative regulation of angiogenesis, negative regulation of endopeptidase activity, ...
Component axon, axon hillock, ...
Function serine-type endopeptidase inhibitor activity
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (383)    Tissues (151)    Images (44)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 375
Northern blot 8
cDNA source data(270)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(274) cDNA(273) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000006203 (Evidence)
Ensembl Gene ModelENSMUSG00000000753 (Evidence)
Entrez Gene20317 (Evidence)
UniGene2044
DFCITC1572018, TC1628078
DoTSDT.496684, DT.99858581
NIA Mouse Gene IndexU033077
Consensus CDS ProjectCCDS25045.1
International Mouse Knockout Project StatusSerpinf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006203 VEGA Gene Model | MGI Sequence Detail 12933 C57BL/6J ±  kb
transcript OTTMUST00000013988 VEGA | MGI Sequence Detail 1832 Not Applicable 
polypeptide OTTMUSP00000006497 VEGA | MGI Sequence Detail 417 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(2) UniProt(13)
Polymorphisms
SNPs within 2kb(91 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023795 Protease inhibitor I4, serpin, conserved site
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000014705 pigment epithelium-derived factor
References
(Earliest) J:22201 Pignolo RJ, et al., Analysis of EPC-1 growth state-dependent expression, specificity, and conservation of related sequences. J Cell Physiol. 1995 Jan;162(1):110-8
(Latest) J:210189 Shin ES, et al., PEDF expression regulates the proangiogenic and proinflammatory phenotype of the lung endothelium. Am J Physiol Lung Cell Mol Physiol. 2014 Apr 1;306(7):L620-34
All references(57)
Other
accession IDs
MGD-MRK-23945, MGD-MRK-37117, MGI:103081, MGI:2144083

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory