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Serpinf1
Gene Detail
Symbol

Name
ID
Serpinf1
serine (or cysteine) peptidase inhibitor, clade F, member 1
MGI:108080
Synonyms
alpha-2 antiplasmin, EPC-1, Pedf, Pedfl, pigment epithelium derived factor, Sdf3
Feature Type
protein coding gene
Genetic Map
Chromosome 11
45.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:75409769-75422701 bp, - strand
From VEGA annotation of GRCm38

  12933 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1965  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SERPINF1
Protein SuperFamily: serpin
Gene Tree: Serpinf1

Human
homologs
SERPINF1, serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5176
neXtProt AC: NX_P36955

Human Synonyms: EPC-1, OI12, OI6, PEDF, PIG35

Human Chr (Location): 17p13.3; chr17:1761965-1777565 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SERPINF1

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Genomic Mutations involving Serpinf1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Loss of function results in increased microvasculature, pancreatic enlargement, and prostatic hyperplasia.
 
Interactions
Serpinf1 interacts with 124 markers (Mir1a-1, Mir1a-2, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process negative regulation of angiogenesis, negative regulation of endopeptidase activity, ...
Component axon, axon hillock, ...
Function serine-type endopeptidase inhibitor activity
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (383)    Tissues (151)    Images (44)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 375
Northern blot 8
cDNA source data(270)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase serpinf1 ; ZFIN serpinf1    NEW 
Molecular
reagents
All nucleic(274) cDNA(273) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000006203 (Evidence)
Ensembl Gene Model ENSMUSG00000000753 (Evidence)
Entrez Gene 20317 (Evidence)
UniGene 2044
DFCI TC1628078, TC1572018
DoTS DT.99858581, DT.496684
NIA Mouse Gene Index U033077
Consensus CDS Project CCDS25045.1
International Mouse Phenotyping Consortium Status Serpinf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006203 VEGA Gene Model | MGI Sequence Detail 12933 C57BL/6J ±  kb
transcript OTTMUST00000013988 VEGA | MGI Sequence Detail 1832 Not Applicable 
polypeptide OTTMUSP00000006497 VEGA | MGI Sequence Detail 417 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(2) UniProt(7)
Polymorphisms
SNPs within 2kb(91 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023795 Protease inhibitor I4, serpin, conserved site
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000014705 pigment epithelium-derived factor
References
(Earliest) J:22201 Pignolo RJ, et al., Analysis of EPC-1 growth state-dependent expression, specificity, and conservation of related sequences. J Cell Physiol. 1995 Jan;162(1):110-8
(Latest) J:213597 Lakeland TV, et al., Augmented expression and secretion of adipose-derived pigment epithelium-derived factor does not alter local angiogenesis or contribute to the development of systemic metabolic derangements. Am J Physiol Endocrinol Metab. 2014 Jun 15;306(12):E1367-77
All references(57)
Other
accession IDs
MGD-MRK-23945, MGD-MRK-37117, MGI:103081, MGI:2144083

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory