Phenotypes Associated with This Genotype

Genotype
MGI:5758948

• Allelic Composition: Serpinf1^tm1Craw/Serpinf1^tm1Craw
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased trabecular bone volume ( J:230409 )

• reduction in trabecular bone volume fraction at 12 weeks of age

decreased bone trabecula number ( J:230409 )

• reduction in trabecular numbers at 12 weeks of age

increased osteoid thickness ( J:230409 )

• increase in osteoid thickness and osteoid maturation time in 6 week old mice, suggesting of a defect in the mineralization process

abnormal bone mineralization ( J:230409 )

• increase in the mineral:matrix ratio, indicating an accumulation of unmineralized bone matrix

• matrix mineralization is increased in osteoblast cultures

decreased bone strength ( J:230409 )

• assessment of cortical bone strength suggests that bones re more brittle at 12 weeks of age, with ultimate displacement and energy to failure reduced in bones

• however, parameters of cortical bone structure are not affected

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteogenesis imperfecta type 6		DOID:0110350	OMIM:613982	J:230409