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Wnt10a Gene Detail
Summary
  • Symbol
    Wnt10a
  • Name
    wingless-type MMTV integration site family, member 10A
  • Feature Type
    protein coding gene
  • IDs
    MGI:108071
    NCBI Gene: 22409
  • Gene Overview
    MyGene.info: WNT10A
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:74792019-74804176 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 38.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    37 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108071
protein coding gene Chr1:74791516-74804179 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016163
protein coding gene Chr1:75402286-75414933 (+)
A/J MGP_AJ_G0016146
protein coding gene Chr1:72777605-72789040 (+)
AKR/J MGP_AKRJ_G0016103
protein coding gene Chr1:74783486-74795147 (+)
BALB/cJ MGP_BALBcJ_G0016101
protein coding gene Chr1:72833072-72844447 (+)
C3H/HeJ MGP_C3HHeJ_G0015932
protein coding gene Chr1:75128407-75142191 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016554
protein coding gene Chr1:78342133-78354075 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014275
protein coding gene Chr1:68341673-68354075 (+)
CAST/EiJ MGP_CASTEiJ_G0015516
protein coding gene Chr1:74451177-74463806 (+)
CBA/J MGP_CBAJ_G0015905
protein coding gene Chr1:80889809-80901174 (+)
DBA/2J MGP_DBA2J_G0016006
protein coding gene Chr1:72094602-72106117 (+)
FVB/NJ MGP_FVBNJ_G0016009
protein coding gene Chr1:71288099-71300028 (+)
LP/J MGP_LPJ_G0016078
protein coding gene Chr1:76519473-76532026 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016029
protein coding gene Chr1:84272634-84287110 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016601
protein coding gene Chr1:74859759-74872421 (+)
PWK/PhJ MGP_PWKPhJ_G0015303
protein coding gene Chr1:71554509-71567519 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015081
protein coding gene Chr1:74227413-74239379 (+)
WSB/EiJ MGP_WSBEiJ_G0015578
protein coding gene Chr1:74673315-74686488 (+)



Homology
more
  • Human Ortholog
    WNT10A, Wnt family member 10A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    WNT10A, Wnt family member 10A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    OODD, SSPS, STHAG4
  • Links
    NCBI Gene ID: 80326
    neXtProt AC: NX_Q9GZT5
    UniProt: Q9GZT5

  • Chr Location
    2q35; chr2:218874116-218893931 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human WNT10A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 3 alleles in 5 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit taurodontism, supernumerary molars, small molars and misshapened crowns. Mice homozygous for a conditional allele activated in Krt14+ cells also exhibit decreased basal cell proliferation affecting the tongue, sweat glands and nails.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22409 NCBI Gene Model | MGI Sequence Detail 12158 C57BL/6J ±  kb
    transcript NM_009518 RefSeq | MGI Sequence Detail 1977 Not Specified  
    polypeptide P70701 UniProt | EBI | MGI Sequence Detail 417 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 1
      cDNA 18
      Primer pair 8
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37108
    References
    more
    • Summaries
      All 113
      Developmental Gene Expression 68
      Gene Ontology 7
      Phenotypes 21
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:260824 Wang KY, et al., Critical in vivo roles of WNT10A in wound healing by regulating collagen expression/synthesis in WNT10A-deficient mice. PLoS One. 2018;13(3):e0195156

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory