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Wnt10a
Gene Detail
Symbol

Name
ID
Wnt10a
wingless-type MMTV integration site family, member 10A
MGI:108071
Feature Type
protein coding gene
Genetic Map
Chromosome 1
38.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:74791516-74804179 bp, + strand
From VEGA annotation of GRCm38

  12664 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22525  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: WNT10A
Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt10a

Human
homologs
WNT10A, wingless-type MMTV integration site family, member 10A
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 80326
neXtProt AC: NX_Q9GZT5

Human Synonyms: OODD, SSPS, STHAG4

Human Chr (Location): 2q35; chr2:218874323-218893931 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human WNT10A

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Radiation induced(1) Targeted(3)
Genomic Mutations involving Wnt10a (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Wnt10a interacts with 72 markers (Mir19a, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cell-cell signaling, cell fate commitment, ...
Component extracellular region, extracellular space, ...
Function frizzled binding, receptor binding
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (54 records)
Data Summary: Results (682)    Tissues (474)    Images (106)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 593
Northern blot 61
RT-PCR 26
RNase protection 2
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA WNT10A ; Xenbase wnt10a ; ZFIN wnt10a    NEW 
Molecular
reagents
All nucleic(28) Genomic(1) cDNA(17) Primer pair(8) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000020879 (Evidence)
Ensembl Gene Model ENSMUSG00000026167 (Evidence)
Entrez Gene 22409 (Evidence)
UniGene 5130
DFCI TC1588606
DoTS DT.55281733
NIA Mouse Gene Index U000462
Consensus CDS Project CCDS15057.1
International Mouse Phenotyping Consortium Status Wnt10a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020879 VEGA Gene Model | MGI Sequence Detail 12664 C57BL/6J ±  kb
transcript OTTMUST00000049359 VEGA | MGI Sequence Detail 2468 Not Applicable 
polypeptide OTTMUSP00000022850 VEGA | MGI Sequence Detail 417 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005817 Wnt
InterPro IPR013302 Wnt-10 protein
InterPro IPR018161 Wnt protein, conserved site
Protein Ontology PR:000017436 protein Wnt-10a
References
(Earliest) J:36010 Wang J, et al., Murine Wnt10a and Wnt10b: cloning and expression in developing limbs, face and skin of embryos and in adults. Oncogene. 1996 Oct 3;13(7):1537-44
(Latest) J:220835 Long A, et al., WNT10A promotes an invasive and self-renewing phenotype in esophageal squamous cell carcinoma. Carcinogenesis. 2015 May;36(5):598-606
All references(86)
Other
accession IDs
MGD-MRK-37108

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory