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Siah1a Gene Detail
Summary
  • Symbol
    Siah1a
  • Name
    siah E3 ubiquitin protein ligase 1A
  • Synonyms
    Sinh1a
  • Feature Type
    protein coding gene
  • IDs
    MGI:108064
    NCBI Gene: 20437
  • Gene Overview
    MyGene.info: SIAH1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:86724007-86745934 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 42.10 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    61 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108064
protein coding gene Chr8:86720454-86746006 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033909
protein coding gene Chr8:87703138-87725197 (-)
A/J MGP_AJ_G0033892
protein coding gene Chr8:84257676-84280368 (-)
AKR/J MGP_AKRJ_G0033818
protein coding gene Chr8:86751254-86773974 (-)
BALB/cJ MGP_BALBcJ_G0033885
protein coding gene Chr8:84402249-84424812 (-)
C3H/HeJ MGP_C3HHeJ_G0035919
protein coding gene ChrX:162494380-162495804 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036735
protein coding gene ChrX:166897851-166900475 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031347
protein coding gene Chr8:78280094-78305909 (-)
CAST/EiJ MGP_CASTEiJ_G0032926
protein coding gene Chr8:86764776-86792173 (-)
CBA/J MGP_CBAJ_G0033571
protein coding gene Chr8:94154672-94180196 (-)
DBA/2J MGP_DBA2J_G0033724
protein coding gene Chr8:83871351-83893367 (-)
FVB/NJ MGP_FVBNJ_G0035991
protein coding gene ChrX:159341745-159343169 (-)
LP/J MGP_LPJ_G0033816
protein coding gene Chr8:87824897-87847858 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0036023
protein coding gene ChrX:180412063-180417787 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034423
protein coding gene Chr8:86743390-86774439 (-)
PWK/PhJ MGP_PWKPhJ_G0020811
protein coding gene Chr15:35558602-35560460 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032465
protein coding gene Chr8:85494187-85521016 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    SIAH1, siah E3 ubiquitin protein ligase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SIAH1, siah E3 ubiquitin protein ligase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SIAH1A
  • Links
    NCBI Gene ID: 6477
    neXtProt AC: NX_Q8IUQ4
    UniProt: Q8IUQ4

  • Chr Location
    16q12.1; chr16:48360531-48448440 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 20654
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SIAH1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit retarded postnatal growth, and high preweaning and postweaning mortality. Surviving females are subfertile, having few, if any, offspring, while males are sterile due to a block at meiotic metaphase I.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036840 Ensembl Gene Model | MGI Sequence Detail 21928 C57BL/6J ±  kb
    transcript ENSMUST00000045296 Ensembl | MGI Sequence Detail 1968 Not Applicable  
    polypeptide ENSMUSP00000044123 Ensembl | MGI Sequence Detail 282 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 2
      cDNA 14
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-14419, MGD-MRK-37101, MGI:2142639
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 2
      Gene Ontology 11
      Phenotypes 37
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
    • Latest
      J:266142 Grosjean F, et al., Pharmacologic control of oxidative stress and inflammation determines whether diabetic glomerulosclerosis progresses or decreases: A pilot study in sclerosis-prone mice. PLoS One. 2018;13(9):e0204366

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory