About   Help   FAQ
Siah1a
Gene Detail
Symbol

Name
ID
Siah1a
seven in absentia 1A
MGI:108064
Synonyms
Sinh1a
Feature Type
protein coding gene
Genetic Map
Chromosome 8
42.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:86723940-86746006 bp, - strand
From Ensembl annotation of GRCm38

  22067 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20654  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Siah1a

Human
homologs
Human Homolog SIAH1, siah E3 ubiquitin protein ligase 1
NCBI Gene ID 6477
neXtProt AC  NX_Q8IUQ4
Human Synonyms  SIAH1A
Human Chr (Location)  16q12.1; chr16:48360531-48393955 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(34) : Gene trapped(33) Targeted(1)
 
Homozygotes for a targeted null mutation exhibit retarded postnatal growth, and high preweaning and postweaning mortality. Surviving females are subfertile, having few, if any, offspring, while males are sterile due to a block at meiotic metaphase I.
 
Interactions
Siah1a interacts with 185 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (41)    Tissues (30)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 41
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) Genomic(2) cDNA(13)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000036840 (Evidence)
Entrez Gene20437 (Evidence)
EC6.3.2.-
PDB1K2F, 2AN6
Consensus CDS ProjectCCDS22504.1
International Mouse Knockout Project StatusSiah1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036840 Ensembl Gene Model | MGI Sequence Detail 22067 C57BL/6J ±  kb
transcript ENSMUST00000045296 Ensembl | MGI Sequence Detail 2107 Not Applicable 
polypeptide ENSMUSP00000044123 Ensembl | MGI Sequence Detail 282 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(6) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004162 Seven-in-absentia protein, sina
InterPro IPR018121 Seven-in-absentia protein, TRAF-like domain
InterPro IPR013323 SIAH-type domain
InterPro IPR008974 TRAF-like
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR013010 Zinc finger, SIAH-type
Protein Ontology PR:000014860 E3 ubiquitin-protein ligase SIAH1
References
(Earliest) J:23358 Fortini ME, et al., Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation [see comments]. Nature. 1992 Feb 6;355(6360):559-61
(Latest) J:181139 Pang RT, et al., miR-135A regulates preimplantation embryo development through down-regulation of E3 Ubiquitin Ligase Seven In Absentia Homolog 1A (SIAH1A) expression. PLoS One. 2011;6(11):e27878
All references(47)
Other
accession IDs
MGD-MRK-14419, MGD-MRK-37101, MGI:2142639

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory