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Siah1a Gene Detail
Summary
  • Symbol
    Siah1a
  • Name
    seven in absentia 1A
  • Synonyms
    Sinh1a
  • Feature Type
    protein coding gene
  • IDs
    MGI:108064
    NCBI Gene: 20437
  • Gene Overview
    MyGene.info: SIAH1
Location & Maps
more
  • Sequence Map
    Chr8:86724007-86745934 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21928 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 42.10 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SIAH1, siah E3 ubiquitin protein ligase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SIAH1, siah E3 ubiquitin protein ligase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SIAH1A
  • Links
    NCBI Gene ID: 6477
    neXtProt AC: NX_Q8IUQ4

  • Chr Location
    16q12.1; chr16:48360531-48448440 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 20654
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: SIAH1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    35
  • Gene trapped
    33
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving Siah1a
Homozygotes for a targeted null mutation exhibit retarded postnatal growth, and high preweaning and postweaning mortality. Surviving females are subfertile, having few, if any, offspring, while males are sterile due to a block at meiotic metaphase I.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000061427 VEGA Gene Model | MGI Sequence Detail 21928 C57BL/6J ±  kb
transcript OTTMUST00000149895 VEGA | MGI Sequence Detail 1968 Not Applicable  
polypeptide OTTMUSP00000077774 VEGA | MGI Sequence Detail 282 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    61 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    Genomic 2
    cDNA 13

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-14419, MGD-MRK-37101, MGI:2142639
References
more
  • Summaries
    All 47
    Developmental Gene Expression 2
    Gene Ontology 10
    Phenotypes 35
  • Earliest
    J:23358 Fortini ME, et al., Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation [see comments]. Nature. 1992 Feb 6;355(6360):559-61
  • Latest
    J:181139 Pang RT, et al., miR-135A regulates preimplantation embryo development through down-regulation of E3 Ubiquitin Ligase Seven In Absentia Homolog 1A (SIAH1A) expression. PLoS One. 2011;6(11):e27878

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory