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Rit1 Gene Detail
Summary
  • Symbol
    Rit1
  • Name
    Ras-like without CAAX 1
  • Synonyms
    Rit
  • Feature Type
    protein coding gene
  • IDs
    MGI:108053
    NCBI Gene: 19769
  • Gene Overview
    MyGene.info: RIT1
Location & Maps
more
  • Sequence Map
    Chr3:88716838-88731049 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14212 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RIT1, Ras like without CAAX 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RIT1, Ras like without CAAX 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NS8, RIBB, RIT, ROC1
  • Links
    NCBI Gene ID: 6016
    neXtProt AC: NX_Q92963

  • Chr Location
    1q22; chr1:155897808-155911402 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human RIT1 associations

Human Disease Mouse Models
       Noonan Syndrome 8; NS8   OMIM: 615355
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Rit1
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele produce embryonic fibroblasts that exhibit increased cellular sensitivity to hydrogen peroxide.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035185 VEGA Gene Model | MGI Sequence Detail 14212 C57BL/6J ±  kb
transcript OTTMUST00000089625 VEGA | MGI Sequence Detail 1204 Not Applicable  
polypeptide OTTMUSP00000049004 VEGA | MGI Sequence Detail 219 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    77 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000014028 GTP-binding protein Rit1
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR001806 Small GTPase superfamily
    IPR020849 Small GTPase superfamily, Ras type
    IPR005225 Small GTP-binding protein domain
Molecular
Reagents
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  • All nucleic 40
    cDNA 40

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-37089
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:36057 Lee CHJ, et al., Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins. J Neurosci. 1996 Nov 1;16(21):6784-94
  • Latest
    J:197491 Cai W, et al., Rit GTPase regulates a p38 MAPK-dependent neuronal survival pathway. Neurosci Lett. 2012 Dec 7;531(2):125-30

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory