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Rit1
Gene Detail
Symbol

Name
ID
Rit1
Ras-like without CAAX 1
MGI:108053
Synonyms
Rit
Feature Type
protein coding gene
Genetic Map
Chromosome 3
38.95 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:88716838-88731049 bp, + strand
From VEGA annotation of GRCm38

  14212 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56003  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RIT1
Protein SuperFamily: ras protein
Gene Tree: Rit1

Human
homologs
RIT1, Ras-like without CAAX 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6016
neXtProt AC: NX_Q92963

Human Synonyms: NS8, RIBB, RIT, ROC1

Human Chr (Location): 1q22; chr1:155897808-155911402 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human RIT1

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(2) Targeted(1)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele produce embryonic fibroblasts that exhibit increased cellular sensitivity to hydrogen peroxide.
 
Interactions
Rit1 interacts with 240 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process Ras protein signal transduction, signal transduction, ...
Component intracellular, membrane, ...
Function GTP binding, nucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (90)    Tissues (14)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 90
cDNA source data(39)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rit1    NEW 
Molecular
reagents
All nucleic(40) cDNA(40)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000035185 (Evidence)
Ensembl Gene Model ENSMUSG00000028057 (Evidence)
Entrez Gene 19769 (Evidence)
UniGene 4009
DFCI TC1631012, TC1599738, TC1580735
DoTS DT.111063916, DT.97405914, DT.94301493, DT.94301492, DT.99854248
NIA Mouse Gene Index U003446
Consensus CDS Project CCDS17484.1, CCDS50952.1
International Mouse Phenotyping Consortium Status Rit1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035185 VEGA Gene Model | MGI Sequence Detail 14212 C57BL/6J ±  kb
transcript OTTMUST00000089625 VEGA | MGI Sequence Detail 1204 Not Applicable 
polypeptide OTTMUSP00000049004 VEGA | MGI Sequence Detail 219 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(11) UniProt(5)
Polymorphisms
SNPs within 2kb(80 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR020849 Small GTPase superfamily, Ras type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000014028 GTP-binding protein Rit1
References
(Earliest) J:36057 Lee CHJ, et al., Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins. J Neurosci. 1996 Nov 1;16(21):6784-94
(Latest) J:197491 Cai W, et al., Rit GTPase regulates a p38 MAPK-dependent neuronal survival pathway. Neurosci Lett. 2012 Dec 7;531(2):125-30
All references(33)
Other
accession IDs
MGD-MRK-37089

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory