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Gcm1 Gene Detail
Summary
  • Symbol
    Gcm1
  • Name
    glial cells missing homolog 1
  • Synonyms
    Gcm 1, Gcm1-rs1, Gcm a, GCMa, glial cell deficient, glide
  • Feature Type
    protein coding gene
  • IDs
    MGI:108045
    NCBI Gene: 14531
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:77959240-77972906 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 43.49 cM, cytoband E1-E3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    447 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108045
 protein coding gene Chr9:77959206-77972906 (+)
129S1/SvImJ ENSMUSG00200019050
 protein coding gene Chr9:75109272-75123407 (+)
A/J ENSMUSG00195010073
 protein coding gene Chr9:74876820-74890802 (+)
AKR/J ENSMUSG00220014391
 protein coding gene Chr9:75009605-75023604 (+)
BALB/cJ ENSMUSG00180016238
 protein coding gene Chr9:74990365-75004360 (+)
C3H/HeJ ENSMUSG00175011565
 protein coding gene Chr9:75022833-75036807 (+)
C57BL/6NJ ENSMUSG00215010983
 protein coding gene Chr9:74918994-74933130 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032458
 protein coding gene Chr9:75012898-75026228 (+)
CAST/EiJ ENSTCUG00005009067
 protein coding gene Chr9:74671564-74685497 (+)
CBA/J ENSMUSG00210013151
 protein coding gene Chr9:75075805-75089802 (+)
DBA/2J ENSMUSG00185006853
 protein coding gene Chr9:75110516-75124513 (+)
FVB/NJ ENSMUSG00205017060
 protein coding gene Chr9:75378973-75392965 (+)
JF1/MsJ ENSUMUG00000018757
 protein coding gene Chr9:75064635-75078560 (+)
LP/J ENSMUSG00230022850
 protein coding gene Chr9:75260883-75275018 (+)
NOD/ShiLtJ ENSMUSG00190024237
 protein coding gene Chr9:75213017-75227007 (+)
NZO/HlLtJ ENSMUSG00225025180
 protein coding gene Chr9:75408440-75422446 (+)
PWK/PhJ ENSLUMG00010015259
 protein coding gene Chr9:74989072-75002670 (+)
SPRET/EiJ ENSMSPG00010003876
 protein coding gene Chr9:76212082-76225425 (+)
WSB/EiJ ENSIUOG00005023847
 protein coding gene Chr9:74534833-74549067 (+)



Homology
more
  • Human Ortholog
    GCM1, GCM transcription factor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GCM1, GCM transcription factor 1
  • Synonyms
    GCMA, hGCMa
  • Links
    NCBI Gene ID: 8521
    UniProt: Q9NP62

  • Chr Location
    6p12.1; chr6:53126961-53148841 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 4 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impaired branching of the chorioallantoic interface, absence of the placental labyrinth, lack of fusion of chorionic trophoblast cells, and lethality between embryonic days 5.5-10.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    994
  • Tissues
    108
  • cDNA Data
    9
  • Literature Summary
    114
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14531 NCBI Gene Model | MGI Sequence Detail 13667 C57BL/6J ±  kb
    transcript NM_008103 RefSeq | MGI Sequence Detail 2034 ZRU/MplStud  
    polypeptide P70348 UniProt | EBI | MGI Sequence Detail 436 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 1
      cDNA 12
      Primer pair 11
      Other 9
      Antibodies 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37081
    References
    more
    • Summaries
      All 160
      Developmental Gene Expression 114
      Gene Ontology 14
      Phenotypes 21
    • Earliest
      J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
    • Latest
      J:386951 Guertin TM, et al., Onset of embryonic and placental defects coincide in 19 of 22 novel mid-gestation lethal murine knockout lines. Development. 2026 May 15;153(10):dev205276
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory