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Gcm1 Gene Detail
Summary
  • Symbol
    Gcm1
  • Name
    glial cells missing homolog 1 (Drosophila)
  • Synonyms
    Gcm 1, Gcm1-rs1, Gcm a, GCMa, glial cell deficient, glide
  • Feature Type
    protein coding gene
  • IDs
    MGI:108045
    NCBI Gene: 14531
  • Gene Overview
    MyGene.info: GCM1
Location & Maps
more
  • Sequence Map
    Chr9:78051958-78065624 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13667 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 43.49 cM, cytoband E1-E3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GCM1, glial cells missing homolog 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GCM1, glial cells missing homolog 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GCMA, hGCMa
  • Links
    NCBI Gene ID: 8521
    neXtProt AC: NX_Q9NP62

  • Chr Location
    6p12.1; chr6:53126961-53148826 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 4 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Gcm1
  • Incidental Mutations
    APF
Homozygotes for targeted null mutations exhibit impaired branching of the chorioallantoic interface, absence of the placental labyrinth, lack of fusion of chorionic trophoblast cells, and lethality between embryonic days 5.5-10.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14531 NCBI Gene Model | MGI Sequence Detail 13667 C57BL/6J ±  kb
transcript NM_008103 RefSeq | MGI Sequence Detail 2034 C57BL/6  
polypeptide P70348 UniProt | EBI | MGI Sequence Detail 436 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    64 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007899 chorion-specific transcription factor GCMa
  • PDB
  • InterPro Domains
    IPR003902 Transcription regulator GCM domain
Molecular
Reagents
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  • All nucleic 17
    Genomic 1
    cDNA 10
    Primer pair 3
    Other 3

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-37081
References
more
  • Summaries
    All 98
    Developmental Gene Expression 67
    Gene Ontology 10
    Phenotypes 20
  • Earliest
    J:35366 Altshuller Y, et al., Gcm1, a mammalian homolog of Drosophila glial cells missing. FEBS Lett. 1996 Sep 16;393(2-3):201-4
  • Latest
    J:231798 Chen CY, et al., Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis. Hum Mol Genet. 2016 May 14;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory