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Scn10a Gene Detail
Summary
  • Symbol
    Scn10a
  • Name
    sodium channel, voltage-gated, type X, alpha
  • Synonyms
    Nav1.8
  • Feature Type
    protein coding gene
  • IDs
    MGI:108029
    NCBI Gene: 20264
  • Gene Overview
    MyGene.info: SCN10A
Location & Maps
more
  • Sequence Map
    Chr9:119608456-119719322 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      110867 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 71.33 cM, cytoband distal
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    SCN10A, sodium voltage-gated channel alpha subunit 10
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SCN10A, sodium voltage-gated channel alpha subunit 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FEPS2, hPN3, Nav1.8, PN3, SNS
  • Links
    NCBI Gene ID: 6336
    neXtProt AC: NX_Q9Y5Y9
    UniProt: Q9Y5Y9

  • Chr Location
    3p22.2; chr3:38697110-38794010 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 3 alleles in 5 genetic backgrounds
    19 phenotypes from multigenic genotypes
    1 images
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit impaired perception of pain. Mice homozygous or heterozygous for an ENU-induced allele exhibit a catalepsy phenotype following scruffing and increased sensitivity to cold pain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20264 NCBI Gene Model | MGI Sequence Detail 110867 C57BL/6J ±  kb
transcript NM_001205321 RefSeq | MGI Sequence Detail 6416 C57BL/6  
polypeptide Q6QIY3 UniProt | EBI | MGI Sequence Detail 1958 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1283 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 15
    Genomic 9
    cDNA 4
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-37065
References
more
  • Summaries
    All 92
    Developmental Gene Expression 10
    Gene Ontology 7
    Phenotypes 58
  • Earliest
    J:35911 Kozak CA, et al., Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouse. Mamm Genome. 1996 Oct;7(10):787-8
  • Latest
    J:242216 Klein AH, et al., Sodium Channel Nav1.8 Underlies TTX-Resistant Axonal Action Potential Conduction in Somatosensory C-Fibers of Distal Cutaneous Nerves. J Neurosci. 2017 May 17;37(20):5204-5214

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory