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Scn10a
Gene Detail
Symbol

Name
ID
Scn10a
sodium channel, voltage-gated, type X, alpha
MGI:108029
Synonyms
Nav1.8
Feature Type
protein coding gene
Genetic Map
Chromosome 9
71.33 cM, cytoband distal
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr9:119608456-119719032 bp, - strand
From NCBI annotation of GRCm38

  110577 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21300  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: SCN10A
Protein SuperFamily: voltage-gated sodium channel
Gene Tree: Scn10a

Human
homologs
SCN10A, sodium channel, voltage gated, type X alpha subunit
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6336
neXtProt AC: NX_Q9Y5Y9

Human Synonyms: FEPS2, hPN3, Nav1.8, PN3, SNS

Human Chr (Location): 3p22.2; chr3:38696891-38794010 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SCN10A

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit impaired perception of pain. Mice homozygous or heterozygous for an ENU-induced allele exhibit a catalepsy phenotype following scruffing and increased sensitivity to cold pain.
 
Phenotype Images(1)
Interactions
Scn10a interacts with 116 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process AV node cell action potential, bundle of His cell action potential, ...
Component axon, C-fiber, ...
Function ion channel activity, ion channel binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (36)    Tissues (7)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 33
RT-PCR 3
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) Genomic(9) cDNA(4) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000034533 (Evidence)
Entrez Gene 20264 (Evidence)
DFCI TC1588469
DoTS DT.102553179, DT.91331784, DT.94196150, DT.94283335
NIA Mouse Gene Index U031431
Consensus CDS Project CCDS57716.1
International Mouse Phenotyping Consortium Status Scn10a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20264 NCBI Gene Model | MGI Sequence Detail 110577 C57BL/6J ±  kb
transcript NM_001205321 RefSeq | MGI Sequence Detail 6416 C57BL/6 
polypeptide Q6QIY3 UniProt | EBI | MGI Sequence Detail 1958 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(8) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(1283 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005821 Ion transport domain
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR010526 Sodium ion transport-associated
InterPro IPR027359 Voltage-dependent channel, four helix bundle domain
InterPro IPR028809 Voltage gated sodium channel, alpha-10 subunit
InterPro IPR001696 Voltage gated sodium channel, alpha subunit
Protein Ontology PR:000002096 sodium channel protein type 10 subunit alpha
Graphical View of Protein Domain Structure
References
(Earliest) J:35911 Kozak CA, et al., Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouse. Mamm Genome. 1996 Oct;7(10):787-8
(Latest) J:223498 Garrison SR, et al., A gain-of-function voltage-gated sodium channel 1.8 mutation drives intense hyperexcitability of A- and C-fiber neurons. Pain. 2014 May;155(5):896-905
All references(80)
Other
accession IDs
MGD-MRK-37065

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory