Scn10a
Gene Detail

Symbol Name ID

Scn10a sodium channel, voltage-gated, type X, alpha MGI:108029

Synonyms

Nav1.8, PN3, SNS

Feature Type

protein coding gene

Genetic Map

Chromosome 9

71.33 cM, cytoband distal
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr9:119608456-119719032 bp, - strand From NCBI annotation of GRCm38   110577 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21300  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: voltage-gated sodium channel
Gene Tree: Scn10a

Human homologs

Human Homolog		SCN10A, sodium channel, voltage-gated, type X, alpha subunit
NCBI Gene ID		6336
neXtProt AC		NX_Q9Y5Y9
Human Synonyms		hPN3, Nav1.8, PN3, SNS
Human Chr (Location)		3p22.2; chr3:38738837-38835501 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(4) Chemically induced(1)
 

Homozygotes for a targeted null mutation exhibit impaired perception of pain. Mice homozygous or heterozygous for an ENU-induced allele exhibit a catalepsy phenotype following scruffing and increased sensitivity to cold pain.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (36 annotations)

Process	AV node cell to bundle of His cell communication, bundle of His cell to Purkinje myocyte communication, ...
Component	axon, C-fiber, ...
Function	ion channel activity, sodium channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (36)    Tissues (6)    Images (18)
Theiler Stages: 23, 25, 28

Assay Type	Results
RNA in situ	33
RT-PCR	3

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) Genomic(9) cDNA(6) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000034533 (Evidence)
Entrez Gene	20264 (Evidence)
UniGene	247042
DFCI	TC1588469
DoTS	DT.102553179, DT.91331784, DT.94196150, DT.94283335
NIA Mouse Gene Index	U031431
Consensus CDS Project	CCDS57716.1
International Mouse Knockout Project Status	Scn10a

Sequences

Length	Strain/Species
genomic	20264	NCBI Gene Model | MGI Sequence Detail	110577	C57BL/6J
transcript	NM_001205321	RefSeq | MGI Sequence Detail	6416	C57BL/6
polypeptide	Q6QIY3	UniProt | EBI | MGI Sequence Detail	1958	Not Applicable

All sequences(25) RefSeq(4) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(315 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005821	Ion transport domain
InterPro	IPR000048	IQ motif, EF-hand binding site
InterPro	IPR010526	Sodium ion transport-associated
InterPro	IPR001696	Voltage gated sodium channel, alpha subunit
Protein Ontology	PR:000002096	sodium channel type 10 subunit alpha

Graphical View of Protein Domain Structure

References

(Earliest) J:35911 Kozak CA, et al., Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouse. Mamm Genome. 1996 Oct;7(10):787-8
(Latest) J:190769 van den Boogaard M, et al., Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer. J Clin Invest. 2012 Jul 2;122(7):2519-30
All references(64)

Other accession IDs

MGD-MRK-37065