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Scn10a
Gene Detail
 Symbol
Name
ID
Scn10a
sodium channel, voltage-gated, type X, alpha
MGI:108029
Synonyms Nav1.8
Feature Type protein coding gene
Genetic Map
Chromosome 9
71.33 cM, cytoband distal
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr9:119608456-119719032 bp, - strand
From NCBI annotation of GRCm38

  110577 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21300  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: voltage-gated sodium channel
Gene Tree: Scn10a

Human
homologs
Human Homolog SCN10A, sodium channel, voltage-gated, type X, alpha subunit
NCBI Gene ID 6336
neXtProt AC  NX_Q9Y5Y9
Human Synonyms  FEPS2, hPN3, Nav1.8, PN3, SNS
Human Chr (Location)  3p22.2; chr3:38697346-38794010 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SCN10A
Alleles
and
phenotypes
All alleles(5) : Chemically induced (ENU)(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit impaired perception of pain. Mice homozygous or heterozygous for an ENU-induced allele exhibit a catalepsy phenotype following scruffing and increased sensitivity to cold pain.
 
Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process AV node cell to bundle of His cell communication, bundle of His cell to Purkinje myocyte communication, ...
Component axon, C-fiber, ...
Function ion channel activity, sodium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (36)    Tissues (6)    Images (18)
Theiler Stages: 23, 25, 28
Assay TypeResults
RNA in situ 33
RT-PCR 3
cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(15) Genomic(9) cDNA(4) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000034533 (Evidence)
Entrez Gene20264 (Evidence)
DFCITC1588469
DoTSDT.102553179, DT.91331784, DT.94196150, DT.94283335
NIA Mouse Gene IndexU031431
Consensus CDS ProjectCCDS57716.1
International Mouse Knockout Project StatusScn10a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20264 NCBI Gene Model | MGI Sequence Detail 110577 C57BL/6J ±  kb
transcript NM_001205321 RefSeq | MGI Sequence Detail 6416 C57BL/6 
polypeptide Q6QIY3 UniProt | EBI | MGI Sequence Detail 1958 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(12) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(1283 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005821 Ion transport domain
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR010526 Sodium ion transport-associated
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
InterPro IPR001696 Voltage gated sodium channel, alpha subunit
Protein Ontology PR:000002096 sodium channel protein type 10 subunit alpha
Graphical View of Protein Domain Structure
References (Earliest) J:35911 Kozak CA, et al., Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouse. Mamm Genome. 1996 Oct;7(10):787-8
(Latest) J:208794 Minett MS, et al., Pain without nociceptors? Nav1.7-independent pain mechanisms. Cell Rep. 2014 Jan 30;6(2):301-12
All references(74)
Other
accession IDs
MGD-MRK-37065

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory