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Rad21
Gene Detail
 Symbol
Name
ID
Rad21
RAD21 homolog (S. pombe)
MGI:108016
Synonyms mKIAA0078, SCC1
Feature Type protein coding gene
Genetic Map
Chromosome 15
19.54 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:51962605-51991760 bp, - strand
From Ensembl annotation of GRCm38

  29156 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38161  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

Gene Tree: Rad21

Human
homologs
Human Homolog RAD21, RAD21 homolog (S. pombe)
NCBI Gene ID 5885
neXtProt AC  NX_O60216
Human Synonyms  CDLS4, hHR21, HR21, HRAD21, MCD1, NXP1, SCC1
Human Chr (Location)  8q24; chr8:116845934-116874866 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human RAD21
Mutations,
alleles, and
phenotypes
All mutations/alleles(64) : Gene trapped(60) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted allele exhibit prenatal lethality, reduced male fertility, and produce oocytes that fail to maintain sister chromatids in the first mitosis following fertilization.
 
Interactions
Rad21 interacts with 296 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process apoptotic process, cell cycle, ...
Component chromatin, chromosome, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (140)    Tissues (139)    Images (15)
Theiler Stages: 22, 23, 28
Assay TypeResults
RNA in situ 94
RT-PCR 46
cDNA source data(401)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(403) cDNA(401) Primer pair(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000022314 (Evidence)
Entrez Gene19357 (Evidence)
UniGene182628
DoTSDT.101159619, DT.101393552, DT.110797782, DT.91283800, DT.91585235, DT.94384333
NIA Mouse Gene IndexU036166
Consensus CDS ProjectCCDS27463.1
International Mouse Knockout Project StatusRad21
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022314 Ensembl Gene Model | MGI Sequence Detail 29156 C57BL/6J ±  kb
transcript ENSMUST00000022927 Ensembl | MGI Sequence Detail 3604 Not Applicable 
polypeptide ENSMUSP00000022927 Ensembl | MGI Sequence Detail 635 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(6) UniProt(6)
Polymorphisms SNPs within 2kb(193 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023093 Rad21/Rec8-like protein, C-terminal
InterPro IPR006909 Rad21/Rec8-like protein, C-terminal, eukaryotic
InterPro IPR006910 Rad21/Rec8-like protein, N-terminal
Protein Ontology PR:000013667 double-strand-break repair protein rad21
References (Earliest) J:23956 Haaf T, et al., Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes. Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2298-302
(Latest) J:204095 Remeseiro S, et al., Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome. Biochim Biophys Acta. 2013 Dec;1832(12):2097-102
All references(46)
Other
accession IDs
MGD-MRK-37051

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory