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Rad21 Gene Detail
Summary
  • Symbol
    Rad21
  • Name
    RAD21 cohesin complex component
  • Synonyms
    mKIAA0078, SCC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108016
    NCBI Gene: 19357
  • Gene Overview
    MyGene.info: RAD21
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:51962240-51991747 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29508 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 19.54 cM, cytoband D3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RAD21, RAD21 cohesin complex component
  • Vertebrate Orthologs
    12
  • Human Ortholog
    RAD21, RAD21 cohesin complex component
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDLS4, hHR21, HR21, HRAD21, MCD1, NXP1, SCC1
  • Links
    NCBI Gene ID: 5885
    neXtProt AC: NX_O60216
    UniProt: O60216

  • Chr Location
    8q24.11; chr8:116845934-116874866 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 38161
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;3 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RAD21
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human RAD21 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit prenatal lethality, reduced male fertility, and produce oocytes that fail to maintain sister chromatids in the first mitosis following fertilization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022314 Ensembl Gene Model | MGI Sequence Detail 29508 C57BL/6J ±  kb
    transcript ENSMUST00000022927 Ensembl | MGI Sequence Detail 3956 Not Applicable  
    polypeptide ENSMUSP00000022927 Ensembl | MGI Sequence Detail 635 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      195 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000013667 double-strand-break repair protein rad21
    • InterPro Domains
      IPR006909 Rad21/Rec8-like protein, C-terminal, eukaryotic
      IPR006910 Rad21/Rec8-like protein, N-terminal
      IPR036390 Winged helix DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 403
      cDNA 401
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-37051
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 10
      Phenotypes 19
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:258320 Gassler J, et al., A mechanism of cohesin-dependent loop extrusion organizes zygotic genome architecture. EMBO J. 2017 Dec 15;36(24):3600-3618

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory