Rad21
Gene Detail

Symbol Name ID

Rad21 RAD21 homolog (S. pombe) MGI:108016

Synonyms

mKIAA0078, SCC1

Feature Type

protein coding gene

Genetic Map

Chromosome 15

19.54 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:51962605-51991760 bp, - strand From Ensembl annotation of GRCm38   29156 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:38161  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 3 zebrafish

Gene Tree: Rad21

Human homologs

Human Homolog		RAD21, RAD21 homolog (S. pombe)
NCBI Gene ID		5885
neXtProt AC		NX_O60216
Human Synonyms		CDLS4, hHR21, HR21, HRAD21, MCD1, NXP1, SCC1
Human Chr (Location)		8q24; chr8:117858173-117887105 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human RAD21

Alleles and phenotypes

All alleles(64) : Targeted(4) Gene trapped(60)
 

Mice homozygous for a targeted allele exhibit prenatal lethality, reduced male fertility, and produce oocytes that fail to maintain sister chromatids in the first mitosis following fertilization.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	apoptotic process, cell cycle, ...
Component	chromosome, chromosome, centromeric region, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (140)    Tissues (139)    Images (15)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	94
RT-PCR	46

cDNA source data(401)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(403) cDNA(401) Primer pair(2)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000022314 (Evidence)
Entrez Gene	19357 (Evidence)
UniGene	182628
DoTS	DT.101159619, DT.101393552, DT.110797782, DT.91283800, DT.91585235, DT.94384333
NIA Mouse Gene Index	U036166
Consensus CDS Project	CCDS27463.1
International Mouse Knockout Project Status	Rad21

Sequences

Length	Strain/Species
genomic	ENSMUSG00000022314	Ensembl Gene Model | MGI Sequence Detail	29156	C57BL/6J
transcript	ENSMUST00000022927	Ensembl | MGI Sequence Detail	3604	Not Applicable
polypeptide	ENSMUSP00000022927	Ensembl | MGI Sequence Detail	635	Not Applicable

All sequences(41) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(173 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023093	Rad21/Rec8-like protein, C-terminal
InterPro	IPR006909	Rad21/Rec8-like protein, C-terminal, eukaryotic
InterPro	IPR006910	Rad21/Rec8-like protein, N-terminal
Protein Ontology	PR:000013667	double-strand-break repair protein rad21

References

(Earliest) J:23956 Haaf T, et al., Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes. Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2298-302
(Latest) J:188795 Faure AJ, et al., Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules. Genome Res. 2012 Nov;22(11):2163-75
All references(45)

Other accession IDs

MGD-MRK-37051