Klc1
Gene Detail

Symbol Name ID

Klc1 kinesin light chain 1 MGI:107978

Synonyms

Kns2

Feature Type

protein coding gene

Genetic Map

Chromosome 12

61.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr12:111758849-111807844 bp, + strand From VEGA annotation of GRCm38   48996 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4056  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinesin light chain
Gene Tree: Klc1

Human homologs

Human Homolog		KLC1, kinesin light chain 1
NCBI Gene ID		3831
neXtProt AC		NX_Q07866
Human Synonyms		KLC, KNS2, KNS2A
Human Chr (Location)		14q32.3; chr14:104095525-104167888 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(52) : Targeted(4) Gene trapped(48)
 

Mice homozygous for disruptions in this gene are significantly smaller than normal.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	axon cargo transport, intracellular protein transport, ...
Component	axon, ciliary rootlet, ...
Function	microtubule motor activity, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (189)    Tissues (47)    Images (38)
Theiler Stages: 19, 23, 26, 28

Assay Type	Results
RNA in situ	186
Western blot	3

cDNA source data(177)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(177) cDNA(177)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000027507 (Evidence)
Ensembl Gene Model	ENSMUSG00000021288 (Evidence)
Entrez Gene	16593 (Evidence)
UniGene	278357
DFCI	TC1571986, TC1579307, TC1591654, TC1592337, TC1594858, TC1678047, TC1681352
DoTS	DT.101312552, DT.101366661, DT.101390752, DT.101741341, DT.94176315, DT.94176329, DT.94176347, DT.97363011, DT.97363013, DT.97376867, DT.99863211
NIA Mouse Gene Index	U014435, U321972, U321995
Consensus CDS Project	CCDS36565.1, CCDS49182.1, CCDS49183.1
International Mouse Knockout Project Status	Klc1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027507	VEGA Gene Model | MGI Sequence Detail	48996	C57BL/6J
transcript	OTTMUST00000068082	VEGA | MGI Sequence Detail	2504	Not Applicable
polypeptide	OTTMUSP00000034356	VEGA | MGI Sequence Detail	616	Not Applicable

All sequences(106) RefSeq(11) UniProt(14)

Polymorphisms

RFLP(1) : SNPs(266 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002151	Kinesin light chain
InterPro	IPR015792	Kinesin light chain repeat
InterPro	IPR015390	Rabaptin, GTPase-Rab5 binding domain
InterPro	IPR011990	Tetratricopeptide-like helical
InterPro	IPR019734	Tetratricopeptide repeat
InterPro	IPR013026	Tetratricopeptide repeat-containing domain
InterPro	IPR001440	Tetratricopeptide TPR-1
InterPro	IPR013105	Tetratricopeptide TPR2
Protein Ontology	PR:000009349	kinesin light chain 1

References

(Earliest) J:37953 Lan Y, et al., The Jagged2 gene maps to chromosome 12 and is a candidate for the lgl and sm mutations. Mamm Genome. 1997;8(11):875-6
(Latest) J:184761 Szpankowski L, et al., Subpixel colocalization reveals amyloid precursor protein-dependent kinesin-1 and dynein association with axonal vesicles. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8582-7
All references(65)

Other accession IDs

MGD-MRK-36558, MGI:2144913