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Klc1
Gene Detail
Symbol

Name
ID
Klc1
kinesin light chain 1
MGI:107978
Synonyms
Kns2
Feature Type
protein coding gene
Genetic Map
Chromosome 12
61.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr12:111758849-111807844 bp, + strand
From VEGA annotation of GRCm38

  48996 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4056  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KLC1
Protein SuperFamily: kinesin light chain
Gene Tree: Klc1

Human
homologs
KLC1, kinesin light chain 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3831
neXtProt AC: NX_Q07866

Human Synonyms: KLC, KNS2, KNS2A

Human Chr (Location): 14q32.3; chr14:103629188-103701551 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(54) : Gene trapped(48) Targeted(4) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene are significantly smaller than normal.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Klc1 interacts with 113 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process axon cargo transport, intracellular protein transport, ...
Component axon, cell, ...
Function microtubule motor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (189)    Tissues (47)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 186
Western blot 3
cDNA source data(175)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase klc1 ; ZFIN klc1a    NEW 
Molecular
reagents
All nucleic(175) cDNA(175)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000027507 (Evidence)
Ensembl Gene Model ENSMUSG00000021288 (Evidence)
Entrez Gene 16593 (Evidence)
UniGene 278357
DFCI TC1571986, TC1579307, TC1591654, TC1592337, TC1594858, TC1678047, TC1681352
DoTS DT.101312552, DT.101366661, DT.101390752, DT.101741341, DT.110934235, DT.94176315, DT.94176329, DT.94176347, DT.97363011, DT.97363013, DT.97376867, DT.99863211
NIA Mouse Gene Index U014435, U321972, U321995
Consensus CDS Project CCDS36565.1, CCDS49182.1, CCDS49183.1, CCDS70423.1
International Mouse Phenotyping Consortium Status Klc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027507 VEGA Gene Model | MGI Sequence Detail 48996 C57BL/6J ±  kb
transcript OTTMUST00000068082 VEGA | MGI Sequence Detail 2504 Not Applicable 
polypeptide OTTMUSP00000034356 VEGA | MGI Sequence Detail 616 Not Applicable 

For the selected sequences
All sequences(143) RefSeq(34) UniProt(14)
Polymorphisms
RFLP(1) : SNPs within 2kb(659 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002151 Kinesin light chain
InterPro IPR015792 Kinesin light chain repeat
InterPro IPR015390 Rabaptin, GTPase-Rab5 binding domain
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR001440 Tetratricopeptide TPR-1
InterPro IPR013105 Tetratricopeptide TPR2
Protein Ontology PR:000009349 kinesin light chain 1
References
(Earliest) J:37953 Lan Y, et al., The Jagged2 gene maps to chromosome 12 and is a candidate for the lgl and sm mutations. Mamm Genome. 1997;8(11):875-6
(Latest) J:200654 Barry J, et al., Activation of conventional kinesin motors in clusters by Shaw voltage-gated K+ channels. J Cell Sci. 2013 May 1;126(Pt 9):2027-41
All references(69)
Other
accession IDs
MGD-MRK-36558, MGI:2144913

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory