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Klc1
Gene Detail
Symbol

Name
ID
Klc1
kinesin light chain 1
MGI:107978
Synonyms
Kns2
Feature Type
protein coding gene
Genetic Map
Chromosome 12
61.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr12:111758849-111807844 bp, + strand
From VEGA annotation of GRCm38

  48996 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4056  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinesin light chain
Gene Tree: Klc1

Human
homologs
Human Homolog KLC1, kinesin light chain 1
NCBI Gene ID 3831
neXtProt AC  NX_Q07866
Human Synonyms  KLC, KNS2, KNS2A
Human Chr (Location)  14q32.3; chr14:103629188-103701551 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(52) : Gene trapped(48) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene are significantly smaller than normal.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Klc1 interacts with 113 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process axon cargo transport, intracellular protein transport, ...
Component axon, cell, ...
Function microtubule motor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (189)    Tissues (47)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 186
Western blot 3
cDNA source data(175)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(175) cDNA(175)
Microarray probesets(7)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027507 VEGA Gene Model | MGI Sequence Detail 48996 C57BL/6J ±  kb
transcript OTTMUST00000068082 VEGA | MGI Sequence Detail 2504 Not Applicable 
polypeptide OTTMUSP00000034356 VEGA | MGI Sequence Detail 616 Not Applicable 

For the selected sequences
All sequences(155) RefSeq(34) UniProt(27)
Polymorphisms
RFLP(1) : SNPs within 2kb(659 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002151 Kinesin light chain
InterPro IPR015792 Kinesin light chain repeat
InterPro IPR015390 Rabaptin, GTPase-Rab5 binding domain
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR001440 Tetratricopeptide TPR-1
InterPro IPR013105 Tetratricopeptide TPR2
Protein Ontology PR:000009349 kinesin light chain 1
References
(Earliest) J:37953 Lan Y, et al., The Jagged2 gene maps to chromosome 12 and is a candidate for the lgl and sm mutations. Mamm Genome. 1997;8(11):875-6
(Latest) J:200654 Barry J, et al., Activation of conventional kinesin motors in clusters by Shaw voltage-gated K+ channels. J Cell Sci. 2013 May 1;126(Pt 9):2027-41
All references(71)
Other
accession IDs
MGD-MRK-36558, MGI:2144913

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory