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Phenotypes Associated with This Genotype
Genotype
MGI:3582996
Allelic
Composition		 Klc1tm1Gsn/Klc1+
Tg(APP695)3Dbo/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klc1tm1Gsn mutation (1 available); any Klc1 mutation (56 available)
Tg(APP695)3Dbo mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:96346 )
• levels of amyloid beta are consistently elevated relative to controls
abnormal axon morphology ( J:96346 )
• increased axonal swelling independent of amyloid deposition

homeostasis/metabolism
amyloid beta deposits ( J:96346 )
• levels of amyloid beta are consistently elevated relative to controls

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:96346

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory