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Klc2 Gene Detail
Summary
  • Symbol
    Klc2
  • Name
    kinesin light chain 2
  • Synonyms
    8030455F02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:107953
    NCBI Gene: 16594
  • Gene Overview
    MyGene.info: KLC2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:5107746-5118560 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.25 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    37 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107953
protein coding gene Chr19:5107746-5118573 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024694
protein coding gene Chr19:2034787-2047625 (-)
A/J MGP_AJ_G0024660
protein coding gene Chr19:1935200-1945987 (-)
AKR/J MGP_AKRJ_G0024633
protein coding gene Chr19:1982861-1993648 (-)
BALB/cJ MGP_BALBcJ_G0024660
protein coding gene Chr19:1928669-1940349 (-)
C3H/HeJ MGP_C3HHeJ_G0024428
protein coding gene Chr19:1985331-1996111 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025107
protein coding gene Chr19:2092008-2102821 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022537
protein coding gene Chr19:1863230-1874106 (-)
CAST/EiJ MGP_CASTEiJ_G0023900
protein coding gene Chr19:2011273-2024148 (-)
CBA/J MGP_CBAJ_G0024399
protein coding gene Chr19:2175024-2187015 (-)
DBA/2J MGP_DBA2J_G0024527
protein coding gene Chr19:1917824-1928585 (-)
FVB/NJ MGP_FVBNJ_G0024494
protein coding gene Chr19:1919035-1929845 (-)
LP/J MGP_LPJ_G0024613
protein coding gene Chr19:2031153-2041954 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024524
protein coding gene Chr19:2056395-2067173 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025155
protein coding gene Chr19:1985066-1995878 (-)
PWK/PhJ MGP_PWKPhJ_G0023646
protein coding gene Chr19:1955182-1966228 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023451
protein coding gene Chr19:1974070-1986504 (-)
WSB/EiJ MGP_WSBEiJ_G0023962
protein coding gene Chr19:1992958-2005043 (-)



Homology
more
  • Human Ortholog
    KLC2, kinesin light chain 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    KLC2, kinesin light chain 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 64837
    neXtProt AC: NX_Q9H0B6
    UniProt: Q9H0B6

  • Chr Location
    11q13.2; chr11:66257294-66267861 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human KLC2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024862 Ensembl Gene Model | MGI Sequence Detail 10815 C57BL/6J ±  kb
transcript ENSMUST00000116563 Ensembl | MGI Sequence Detail 3169 Not Applicable  
polypeptide ENSMUSP00000112262 Ensembl | MGI Sequence Detail 619 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 54
    cDNA 54

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-36533, MGI:2147719, MGI:2447825
References
more
  • Summaries
    All 41
    Developmental Gene Expression 1
    Gene Ontology 11
    Phenotypes 7
  • Earliest
    J:33932 Lamerdin JE, et al., Sequence analysis of the ERCC2 gene regions in human, mouse, and hamster reveals three linked genes. Genomics. 1996 Jun 15;34(3):399-409
  • Latest
    J:245359 Pernigo S, et al., Structural basis for kinesin-1:cargo recognition. Science. 2013 Apr 19;340(6130):356-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory