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Klc2 Gene Detail
Summary
  • Symbol
    Klc2
  • Name
    kinesin light chain 2
  • Synonyms
    8030455F02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:107953
    NCBI Gene: 16594
  • Gene Overview
    MyGene.info: KLC2
Location & Maps
more
  • Sequence Map
    Chr19:5107746-5118560 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10815 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.25 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    KLC2, kinesin light chain 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    KLC2, kinesin light chain 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 64837
    neXtProt AC: NX_Q9H0B6

  • Chr Location
    11q13.2; chr11:66257294-66267861 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human KLC2 associations

Human Disease Mouse Models
       Spastic Paraplegia, Optic Atrophy, and Neuropathy; SPOAN   OMIM: 609541
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Gene trapped
    2
  • Targeted
    3
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016355 VEGA Gene Model | MGI Sequence Detail 10815 C57BL/6J ±  kb
transcript OTTMUST00000039332 VEGA | MGI Sequence Detail 3169 Not Applicable  
polypeptide OTTMUSP00000017579 VEGA | MGI Sequence Detail 619 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    37 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 53
    cDNA 53

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-36533, MGI:2147719, MGI:2447825
References
more
  • Summaries
    All 41
    Developmental Gene Expression 1
    Gene Ontology 10
    Phenotypes 7
  • Earliest
    J:33932 Lamerdin JE, et al., Sequence analysis of the ERCC2 gene regions in human, mouse, and hamster reveals three linked genes. Genomics. 1996 Jun 15;34(3):399-409
  • Latest
    J:180026 Dodding MP, et al., A kinesin-1 binding motif in vaccinia virus that is widespread throughout the human genome. EMBO J. 2011 Nov 16;30(22):4523-38

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory