Klc2^em1Jgao
Endonuclease-mediated Allele Detail

Summary

• Symbol: Klc2^em1Jgao
• Name: kinesin light chain 2; endonuclease-mediated mutation 1, Jiangang Gao
• MGI ID: MGI:7610562
• Gene: Klc2 Location: Chr19:5157774-5168326 bp, - strand Genetic Position: Chr19, 4.25 cM
• Alliance: Klc2^em1Jgao page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination using guide RNAs targeting between intron 2 and intron 11 created a deletion removing exons 3 - 11. Western blot and q-PCR analysis confirmed the absence of expression in cochlea from homozygous mice. (J:345577)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klc2 Mutation: 20 strains or lines available

References

• Original: J:345577 Fu X, et al., Deficiency of Klc2 Induces Low-Frequency Sensorineural Hearing Loss in C57BL/6 J Mice and Human. Mol Neurobiol. 2021 Sep;58(9):4376-4391
• All: 1 reference(s)