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Lrig1
Gene Detail
Symbol

Name
ID
Lrig1
leucine-rich repeats and immunoglobulin-like domains 1
MGI:107935
Synonyms
Img, LIG-1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
43.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:94604529-94700158 bp, - strand
From VEGA annotation of GRCm38

  95630 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7380  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LRIG1
Gene Tree: Lrig1

Human
homologs
LRIG1, leucine-rich repeats and immunoglobulin-like domains 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 26018
neXtProt AC: NX_Q96JA1

Human Synonyms: LIG1, LIG-1

Human Chr (Location): 3p14; chr3:66378797-66501263 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(1) Gene trapped(2) Spontaneous(1) Targeted(5)
Genomic Mutations involving Lrig1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice developed psoriasiform epidermal hyperplasia. Homozygotes exhibit hair follicle, epidermis, vertebral, eye and hearing abnormalities, decreased body size and fat amount, and increased susceptibility to bacterial infection.
 
Interactions
Lrig1 interacts with 254 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process innervation, otolith morphogenesis, ...
Component integral component of membrane, membrane
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (135)    Tissues (122)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 135
cDNA source data(112)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase lrig1 ; ZFIN lrig1    NEW 
Molecular
reagents
All nucleic(115) cDNA(112) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000024528 (Evidence)
Ensembl Gene Model ENSMUSG00000030029 (Evidence)
Entrez Gene 16206 (Evidence)
UniGene 245210
NIA Mouse Gene Index U027660
Consensus CDS Project CCDS20380.1
International Mouse Phenotyping Consortium Status Lrig1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024528 VEGA Gene Model | MGI Sequence Detail 95630 C57BL/6J ±  kb
transcript OTTMUST00000060197 VEGA | MGI Sequence Detail 4849 Not Applicable 
polypeptide OTTMUSP00000029357 VEGA | MGI Sequence Detail 1091 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(7) UniProt(2)
Polymorphisms
SNPs within 2kb(976 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000009914 leucine-rich repeats and immunoglobulin-like domains protein 1
References
(Earliest) J:35380 Suzuki Y, et al., cDNA cloning of a novel membrane glycoprotein that is expressed specifically in glial cells in the mouse brain. LIG-1, a protein with leucine-rich repeats and immunoglobulin-like domains. J Biol Chem. 1996 Sep 13;271(37):22522-7
(Latest) J:220840 Wang Y, et al., Loss of Lrig1 leads to expansion of brunner glands followed by duodenal adenomas with gastric metaplasia. Am J Pathol. 2015 Apr;185(4):1123-34
All references(56)
Other
accession IDs
MGD-MRK-36515

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory