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Lrig1 Gene Detail
Summary
  • Symbol
    Lrig1
  • Name
    leucine-rich repeats and immunoglobulin-like domains 1
  • Synonyms
    Img, LIG-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107935
    NCBI Gene: 16206
  • Gene Overview
    MyGene.info: LRIG1
Location & Maps
more
  • Sequence Map
    Chr6:94604529-94700158 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      95630 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 43.15 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    LRIG1, leucine rich repeats and immunoglobulin like domains 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRIG1, leucine rich repeats and immunoglobulin like domains 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LIG1, LIG-1
  • Links
    NCBI Gene ID: 26018
    neXtProt AC: NX_Q96JA1

  • Chr Location
    3p14; chr3:66378797-66501263 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7380
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: LRIG1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 5 alleles in 6 genetic backgrounds
    18 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (ENU)
    1
  • Gene trapped
    2
  • Spontaneous
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Lrig1
  • Incidental Mutations
Homozygous null mice developed psoriasiform epidermal hyperplasia. Homozygotes exhibit hair follicle, epidermis, vertebral, eye and hearing abnormalities, decreased body size and fat amount, and increased susceptibility to bacterial infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024528 VEGA Gene Model | MGI Sequence Detail 95630 C57BL/6J ±  kb
transcript OTTMUST00000060276 VEGA | MGI Sequence Detail 4951 Not Applicable  
polypeptide OTTMUSP00000029393 VEGA | MGI Sequence Detail 1091 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    974 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000009914 leucine-rich repeats and immunoglobulin-like domains protein 1
  • InterPro Domains
    IPR000483 Cysteine-rich flanking region, C-terminal
    IPR013098 Immunoglobulin I-set
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR003598 Immunoglobulin subtype 2
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR000372 Leucine-rich repeat N-terminal domain
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
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  • All nucleic 115
    cDNA 112
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-36515
References
more
  • Summaries
    All 60
    Developmental Gene Expression 19
    Gene Ontology 2
    Phenotypes 26
  • Earliest
    J:35380 Suzuki Y, et al., cDNA cloning of a novel membrane glycoprotein that is expressed specifically in glial cells in the mouse brain. LIG-1, a protein with leucine-rich repeats and immunoglobulin-like domains. J Biol Chem. 1996 Sep 13;271(37):22522-7
  • Latest
    J:229257 Gu Z, et al., Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015;10(3):e0121550

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory