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Lrig1 Gene Detail
Summary
  • Symbol
    Lrig1
  • Name
    leucine-rich repeats and immunoglobulin-like domains 1
  • Synonyms
    Img, LIG-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107935
    NCBI Gene: 16206
  • Gene Overview
    MyGene.info: LRIG1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:94604529-94700158 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 43.15 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    974 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107935
protein coding gene Chr6:94604529-94700253 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031065
protein coding gene Chr6:96371808-96469231 (-)
A/J MGP_AJ_G0031034
protein coding gene Chr6:92713487-92810775 (-)
AKR/J MGP_AKRJ_G0030965
protein coding gene Chr6:95258745-95354364 (-)
BALB/cJ MGP_BALBcJ_G0031045
protein coding gene Chr6:92665012-92764705 (-)
C3H/HeJ MGP_C3HHeJ_G0030663
protein coding gene Chr6:89058562-89154388 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031504
protein coding gene Chr6:98792460-98888078 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028670
protein coding gene Chr6:90665386-90762621 (-)
CAST/EiJ MGP_CASTEiJ_G0030152
protein coding gene Chr6:95465948-95562798 (-)
CBA/J MGP_CBAJ_G0030731
protein coding gene Chr6:102561121-102656270 (-)
DBA/2J MGP_DBA2J_G0030884
protein coding gene Chr6:91861735-91957509 (-)
FVB/NJ MGP_FVBNJ_G0030838
protein coding gene Chr6:91077580-91173818 (-)
LP/J MGP_LPJ_G0030964
protein coding gene Chr6:96351037-96447334 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030872
protein coding gene Chr6:106512481-106609700 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031531
protein coding gene Chr6:95128494-95235481 (-)
PWK/PhJ MGP_PWKPhJ_G0029868
protein coding gene Chr6:90875071-90971663 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029697
protein coding gene Chr6:94065569-94161080 (-)
WSB/EiJ MGP_WSBEiJ_G0030236
protein coding gene Chr6:95600316-95695915 (-)



Homology
more
  • Human Ortholog
    LRIG1, leucine rich repeats and immunoglobulin like domains 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRIG1, leucine rich repeats and immunoglobulin like domains 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LIG1, LIG-1
  • Links
    NCBI Gene ID: 26018
    neXtProt AC: NX_Q96JA1
    UniProt: Q96JA1

  • Chr Location
    3p14.1; chr3:66378797-66501124 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7380
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LRIG1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 5 alleles in 7 genetic backgrounds
    18 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice developed psoriasiform epidermal hyperplasia. Homozygotes exhibit hair follicle, epidermis, vertebral, eye and hearing abnormalities, decreased body size and fat amount, and increased susceptibility to bacterial infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030029 Ensembl Gene Model | MGI Sequence Detail 95630 C57BL/6J ±  kb
    transcript ENSMUST00000204645 Ensembl | MGI Sequence Detail 4849 Not Applicable  
    polypeptide ENSMUSP00000144963 Ensembl | MGI Sequence Detail 1091 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 117
      cDNA 112
      Primer pair 3
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36515
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 22
      Gene Ontology 5
      Phenotypes 34
    • Earliest
      J:35380 Suzuki Y, et al., cDNA cloning of a novel membrane glycoprotein that is expressed specifically in glial cells in the mouse brain. LIG-1, a protein with leucine-rich repeats and immunoglobulin-like domains. J Biol Chem. 1996 Sep 13;271(37):22522-7
    • Latest
      J:261638 Liakath-Ali K, et al., An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis. Nature. 2018 Apr;556(7701):376-380

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory