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Sqstm1
Gene Detail
Symbol

Name
ID
Sqstm1
sequestosome 1
MGI:107931
Synonyms
A170, OSF-6, Osi, p62, STAP
Feature Type
protein coding gene
Genetic Map
Chromosome 11
30.36 cM, cytoband B1.2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:50199366-50210827 bp, - strand
From VEGA annotation of GRCm38

  11462 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31202  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Sqstm1

Human
homologs
Human Homolog SQSTM1, sequestosome 1
NCBI Gene ID 8878
neXtProt AC  NX_Q13501
Human Synonyms  A170, OSIL, p60, p62, p62B, PDB3, ZIP3
Human Chr (Location)  5q35; chr5:179806388-179838078 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SQSTM1
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(6) Targeted(9)
 
Mice homozygous for one knock-out allele exhibit impaired osteoclastogenesis in response to osteoclastogenic factors. Mice homozygous and heterozygous for a knock-in allele exhibit osteolytic lesion with increased bone formation, mineral apposition rate, and osteoclast numbers.
 
Human Diseases Modeled Using Mouse Sqstm1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Sqstm1 interacts with 169 markers (Mir7-1, Mir7-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process apoptotic process, autophagy, ...
Component aggresome, autophagic vacuole, ...
Function identical protein binding, K63-linked polyubiquitin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (160)    Tissues (138)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 103
Western blot 7
RT-PCR 50
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(11) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005574 (Evidence)
Ensembl Gene ModelENSMUSG00000015837 (Evidence)
Entrez Gene18412 (Evidence)
NIA Mouse Gene IndexU032722
PDB2ZJD, 2RRU, 3B0F, 3ADE, 3WDZ
Consensus CDS ProjectCCDS24629.1, CCDS70176.1
International Mouse Knockout Project StatusSqstm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005574 VEGA Gene Model | MGI Sequence Detail 11462 C57BL/6J ±  kb
transcript OTTMUST00000012391 VEGA | MGI Sequence Detail 2037 Not Applicable 
polypeptide OTTMUSP00000005736 VEGA | MGI Sequence Detail 442 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000270 Phox/Bem1p
InterPro IPR009060 UBA-like
InterPro IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
InterPro IPR000433 Zinc finger, ZZ-type
Protein Ontology PR:000015603 sequestosome-1
References
(Earliest) J:35262 Ishii T, et al., Murine peritoneal macrophages induce a novel 60-kDa protein with structural similarity to a tyrosine kinase p56lck-associated protein in response to oxidative stress. Biochem Biophys Res Commun. 1996 Sep 13;226(2):456-60
(Latest) J:214237 Valencia T, et al., Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis. Cancer Cell. 2014 Jul 14;26(1):121-35
All references(102)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-36511

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/23/2014
MGI 5.20
The Jackson Laboratory