Sqstm1
Gene Detail

Symbol Name ID

Sqstm1 sequestosome 1 MGI:107931

Synonyms

A170, OSF-6, Osi, p62, STAP

Feature Type

protein coding gene

Genetic Map

Chromosome 11

30.36 cM, cytoband B1.2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:50199366-50210827 bp, - strand From VEGA annotation of GRCm38   11462 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31202  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Gene Tree: Sqstm1

Human homologs

Human Homolog		SQSTM1, sequestosome 1
NCBI Gene ID		8878
neXtProt AC		NX_Q13501
Human Synonyms		A170, OSIL, p60, p62, p62B, PDB3, ZIP3
Human Chr (Location)		5q35; chr5:179233388-179265078 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SQSTM1

Alleles and phenotypes

All alleles(13) : Targeted(7) Gene trapped(6)
 

Mice homozygous for one knock-out allele exhibit impaired osteoclastogenesis in response to osteoclastogenic factors. Mice homozygous and heterozygous for a knock-in allele exhibit osteolytic lesion with increased bone formation, mineral apposition rate, and osteoclast numbers.

 
Human Diseases Modeled Using Mouse Sqstm1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	apoptotic process, autophagy, ...
Component	aggresome, autophagic vacuole, ...
Function	identical protein binding, K63-linked polyubiquitin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (127)    Tissues (110)    Images (8)
Theiler Stages: 15, 17, 19, 21, 23, 26, 28

Assay Type	Results
RNA in situ	70
Western blot	7
RT-PCR	50

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(11) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000005574 (Evidence)
Ensembl Gene Model	ENSMUSG00000015837 (Evidence)
Entrez Gene	18412 (Evidence)
NIA Mouse Gene Index	U032722
PDB	2RRU, 2ZJD, 3ADE, 3B0F
Consensus CDS Project	CCDS24629.1
International Mouse Knockout Project Status	Sqstm1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005574	VEGA Gene Model | MGI Sequence Detail	11462	C57BL/6J
transcript	OTTMUST00000012391	VEGA | MGI Sequence Detail	2037	Not Applicable
polypeptide	OTTMUSP00000005736	VEGA | MGI Sequence Detail	442	Not Applicable

All sequences(37) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(40 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000270	Phox/Bem1p
InterPro	IPR009060	UBA-like
InterPro	IPR015940	Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
InterPro	IPR000433	Zinc finger, ZZ-type
Protein Ontology	PR:000015603	sequestosome-1

References

(Earliest) J:35262 Ishii T, et al., Murine peritoneal macrophages induce a novel 60-kDa protein with structural similarity to a tyrosine kinase p56lck-associated protein in response to oxidative stress. Biochem Biophys Res Commun. 1996 Sep 13;226(2):456-60
(Latest) J:191229 Castillo EF, et al., Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):E3168-76
All references(85)

Other accession IDs

MGD-MRK-36511