About   Help   FAQ
Sqstm1
Gene Detail
Symbol

Name
ID
Sqstm1
sequestosome 1
MGI:107931
Synonyms
A170, OSF-6, Osi, p62, STAP
Feature Type
protein coding gene
Genetic Map
Chromosome 11
30.36 cM, cytoband B1.2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:50199366-50210827 bp, - strand
From VEGA annotation of GRCm38

  11462 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31202  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SQSTM1
Gene Tree: Sqstm1

Human
homologs
SQSTM1, sequestosome 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8878
neXtProt AC: NX_Q13501

Human Synonyms: A170, FTDALS3, OSIL, p60, p62, p62B, PDB3, ZIP3

Human Chr (Location): 5q35; chr5:179806388-179838078 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human SQSTM1

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(6) Targeted(9) Transgenic(2)
 
Mice homozygous for one knock-out allele exhibit impaired osteoclastogenesis in response to osteoclastogenic factors. Mice homozygous and heterozygous for a knock-in allele exhibit osteolytic lesion with increased bone formation, mineral apposition rate, and osteoclast numbers.
 
Human Diseases Modeled in Mice Using Sqstm1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Sqstm1 interacts with 169 markers (Mir7-1, Mir7-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (15 records)
Data Summary: Results (172)    Tissues (138)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 103
Western blot 19
RT-PCR 50
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sqstm1 ; ZFIN sqstm1    NEW 
Molecular
reagents
All nucleic(14) cDNA(11) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005574 (Evidence)
Ensembl Gene Model ENSMUSG00000015837 (Evidence)
Entrez Gene 18412 (Evidence)
NIA Mouse Gene Index U032722
PDB 2ZJD, 2RRU, 3ADE, 3WDZ, 3B0F
Consensus CDS Project CCDS24629.1, CCDS70176.1
International Mouse Phenotyping Consortium Status Sqstm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005574 VEGA Gene Model | MGI Sequence Detail 11462 C57BL/6J ±  kb
transcript OTTMUST00000012391 VEGA | MGI Sequence Detail 2037 Not Applicable 
polypeptide OTTMUSP00000005736 VEGA | MGI Sequence Detail 442 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000270 Phox/Bem1p
InterPro IPR009060 UBA-like
InterPro IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
InterPro IPR000433 Zinc finger, ZZ-type
Protein Ontology PR:000015603 sequestosome-1
References
(Earliest) J:35262 Ishii T, et al., Murine peritoneal macrophages induce a novel 60-kDa protein with structural similarity to a tyrosine kinase p56lck-associated protein in response to oxidative stress. Biochem Biophys Res Commun. 1996 Sep 13;226(2):456-60
(Latest) J:218299 Kurosawa M, et al., Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice. Hum Mol Genet. 2015 Feb 15;24(4):1092-105
All references(109)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-36511

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory