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Sqstm1 Gene Detail
Summary
  • Symbol
    Sqstm1
  • Name
    sequestosome 1
  • Synonyms
    A170, OSF-6, Osi, p62, STAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:107931
    NCBI Gene: 18412
Location & Maps
more
  • Sequence Map
    Chr11:50199366-50210827 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11462 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SQSTM1, sequestosome 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SQSTM1, sequestosome 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    A170, FTDALS3, OSIL, p60, p62, p62B, PDB3, ZIP3
  • Links
    NCBI Gene ID: 8878
    neXtProt AC: NX_Q13501

  • Chr Location
    5q35; chr5:179806388-179838078 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Sqstm1 mouse models; 2 with human SQSTM1 associations

Human Disease Mouse Models
       Paget Disease of Bone 2, Early-Onset; PDB2   OMIM: 602080 View 2 models
       Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis 3; FTDALS3   OMIM: 616437
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    51 phenotypes from 8 alleles in 11 genetic backgrounds
    17 phenotypes from multigenic genotypes
    3 images
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Targeted
    9
  • Transgenic
    2
  • Genomic Mutations
    1 involving Sqstm1
Mice homozygous for one knock-out allele exhibit impaired osteoclastogenesis in response to osteoclastogenic factors. Mice homozygous and heterozygous for a knock-in allele exhibit osteolytic lesion with increased bone formation, mineral apposition rate,and osteoclast numbers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005574 VEGA Gene Model | MGI Sequence Detail 11462 C57BL/6J ±  kb
transcript OTTMUST00000012391 VEGA | MGI Sequence Detail 2037 Not Applicable  
polypeptide OTTMUSP00000005736 VEGA | MGI Sequence Detail 442 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    62 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 11
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36511
References
more
  • Summaries
    All 116
    Developmental Gene Expression 18
    Diseases 2
    Gene Ontology 18
    Phenotypes 43
  • Earliest
    J:35262 Ishii T, et al., Murine peritoneal macrophages induce a novel 60-kDa protein with structural similarity to a tyrosine kinase p56lck-associated protein in response to oxidative stress. Biochem Biophys Res Commun. 1996 Sep 13;226(2):456-60
  • Latest
    J:227471 Antonucci L, et al., Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):E6166-74

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory