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Sqstm1 Gene Detail
Summary
  • Symbol
    Sqstm1
  • Name
    sequestosome 1
  • Synonyms
    A170, OSF-6, Osi, p62, STAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:107931
    NCBI Gene: 18412
  • Gene Overview
    MyGene.info: SQSTM1
  • Alliance
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:50200152-50210820 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 30.36 cM, cytoband B1.2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    60 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107931
protein coding gene Chr11:50199366-50210827 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018243
protein coding gene Chr11:49364110-49377193 (-)
A/J MGP_AJ_G0018211
protein coding gene Chr11:47470785-47483223 (-)
AKR/J MGP_AKRJ_G0018181
protein coding gene Chr11:48982849-48994249 (-)
BALB/cJ MGP_BALBcJ_G0018181
protein coding gene Chr11:47751054-47762569 (-)
C3H/HeJ MGP_C3HHeJ_G0017994
protein coding gene Chr11:48989005-49000632 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018632
protein coding gene Chr11:50826600-50839323 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016284
protein coding gene Chr11:45091540-45102538 (-)
CAST/EiJ MGP_CASTEiJ_G0017556
protein coding gene Chr11:48948783-48970377 (-)
CBA/J MGP_CBAJ_G0017969
protein coding gene Chr11:53188464-53199896 (-)
DBA/2J MGP_DBA2J_G0018076
protein coding gene Chr11:47271181-47282626 (-)
FVB/NJ MGP_FVBNJ_G0018070
protein coding gene Chr11:46895544-46907490 (-)
LP/J MGP_LPJ_G0018151
protein coding gene Chr11:49699154-49710585 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018095
protein coding gene Chr11:54713177-54725934 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018676
protein coding gene Chr11:49089559-49101056 (-)
PWK/PhJ MGP_PWKPhJ_G0017334
protein coding gene Chr11:47662037-47682622 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017129
protein coding gene Chr11:48782019-48796356 (-)
WSB/EiJ MGP_WSBEiJ_G0017609
protein coding gene Chr11:48728966-48740434 (-)



Homology
more
  • Human Ortholog
    SQSTM1, sequestosome 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SQSTM1, sequestosome 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    A170, DMRV, FTDALS3, NADGP, OSIL, p60, p62, p62B, PDB3, ZIP3
  • Links
    NCBI Gene ID: 8878
    neXtProt AC: NX_Q13501
    UniProt: Q13501

  • Chr Location
    5q35.3; chr5:179806388-179838078 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Sqstm1 mouse models; 2 with human SQSTM1 associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    53 phenotypes from 8 alleles in 12 genetic backgrounds
    17 phenotypes from multigenic genotypes
    3 images
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele exhibit impaired osteoclastogenesis in response to osteoclastogenic factors. Mice homozygous and heterozygous for a knock-in allele exhibit osteolytic lesion with increased bone formation, mineral apposition rate,and osteoclast numbers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18412 NCBI Gene Model | MGI Sequence Detail 10669 C57BL/6J ±  kb
    transcript NM_011018 RefSeq | MGI Sequence Detail 2030 C57BL/6  
    polypeptide Q64337 UniProt | EBI | MGI Sequence Detail 442 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 12
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36511
    References
    more
    • Summaries
      All 196
      Developmental Gene Expression 38
      Diseases 2
      Gene Ontology 23
      Phenotypes 69
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:265666 Fratta P, et al., Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis. EMBO J. 2018 Jun 1;37(11)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory