Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 8.1.0)

Enables several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; ionotropic glutamate receptor binding activity; and molecular condensate scaffold activity. Involved in several processes, including aggrephagy; brown fat cell proliferation; and positive regulation of long-term synaptic potentiation. Acts upstream of or within energy homeostasis; negative regulation of transcription by RNA polymerase II; and temperature homeostasis. Located in several cellular components, including aggresome; sperm midpiece; and vacuole. Is active in intracellular membraneless organelle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Paget's disease of bone. Human ortholog(s) of this gene implicated in Paget's disease of bone; Paget's disease of bone 3; distal myopathy with rimmed vacuoles; frontotemporal dementia and/or amyotrophic lateral sclerosis 3; and neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset. Orthologous to human SQSTM1 (sequestosome 1).

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Gene Ontology Evidence Code Abbreviations:

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