GO Annotations Graph

• Symbol: Sqstm1
• Name: sequestosome 1
• ID: MGI:107931

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	IDA	J:167845
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	IPI	J:243400
Molecular Function	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	IDA	J:103614
Molecular Function	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	ISO	J:164563
Molecular Function	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:172364
Molecular Function	GO:0005515	protein binding	IPI	J:130839
Molecular Function	GO:0005515	protein binding	IPI	J:236712
Molecular Function	GO:0005515	protein binding	IPI	J:162670
Molecular Function	GO:0005515	protein binding	IPI	J:146216
Molecular Function	GO:0005515	protein binding	IPI	J:103614
Molecular Function	GO:0005515	protein binding	IPI	J:203811
Molecular Function	GO:0005515	protein binding	IPI	J:172945
Molecular Function	GO:0005515	protein binding	IPI	J:292035
Molecular Function	GO:0005515	protein binding	IPI	J:120306
Molecular Function	GO:0005515	protein binding	IPI	J:120306
Molecular Function	GO:0005515	protein binding	IPI	J:189648
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0005080	protein kinase C binding	ISO	J:155856
Molecular Function	GO:0005080	protein kinase C binding	ISO	J:164563
Molecular Function	GO:0005080	protein kinase C binding	IBA	J:265628
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	ISO	J:164563
Molecular Function	GO:0042169	SH2 domain binding	ISO	J:164563
Molecular Function	GO:0035591	signaling adaptor activity	ISO	J:164563
Molecular Function	GO:0038023	signaling receptor activity	ISO	J:164563
Molecular Function	GO:0003712	transcription coregulator activity	TAS	J:57259
Molecular Function	GO:0043130	ubiquitin binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0140036	ubiquitin-dependent protein binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0016235	aggresome	IBA	J:265628
Cellular Component	GO:0016235	aggresome	IDA	J:189648
Cellular Component	GO:0044753	amphisome	ISO	J:164563
Cellular Component	GO:0044753	amphisome	IBA	J:265628
Cellular Component	GO:0044754	autolysosome	ISO	J:164563
Cellular Component	GO:0044754	autolysosome	IDA	J:228803
Cellular Component	GO:0005776	autophagosome	ISO	J:164563
Cellular Component	GO:0005776	autophagosome	IDA	J:212763
Cellular Component	GO:0005776	autophagosome	ISO	J:215480
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0016234	inclusion body	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0097413	Lewy body	ISO	J:155856
Cellular Component	GO:0005764	lysosome	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	IDA	J:320008
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0000932	P-body	ISO	J:164563
Cellular Component	GO:0000407	phagophore assembly site	IDA	J:167845
Cellular Component	GO:0016605	PML body	ISO	J:164563
Cellular Component	GO:0097225	sperm midpiece	IDA	J:178087
Biological Process	GO:0035973	aggrephagy	ISO	J:164563
Biological Process	GO:0035973	aggrephagy	IBA	J:265628
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0006914	autophagy	IDA	J:162670
Biological Process	GO:0006914	autophagy	ISO	J:164563
Biological Process	GO:0006914	autophagy	IDA	J:172945
Biological Process	GO:0070342	brown fat cell proliferation	IMP	J:292035
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0034614	cellular response to reactive oxygen species	ISO	J:164563
Biological Process	GO:0007032	endosome organization	ISO	J:164563
Biological Process	GO:0007032	endosome organization	IBA	J:265628
Biological Process	GO:0097009	energy homeostasis	IMP	J:292035
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0016236	macroautophagy	ISO	J:164563
Biological Process	GO:0000423	mitophagy	ISO	J:164563
Biological Process	GO:0000423	mitophagy	IBA	J:265628
Biological Process	GO:0031397	negative regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0031397	negative regulation of protein ubiquitination	IDA	J:172945
Biological Process	GO:0031397	negative regulation of protein ubiquitination	IDA	J:162670
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:208209
Biological Process	GO:0000425	pexophagy	ISO	J:164563
Biological Process	GO:0010508	positive regulation of autophagy	ISO	J:164563
Biological Process	GO:1900273	positive regulation of long-term synaptic potentiation	IMP	J:243400
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	IMP	J:243400
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0030163	protein catabolic process	ISO	J:164563
Biological Process	GO:0006606	protein import into nucleus	IDA	J:292035
Biological Process	GO:0006606	protein import into nucleus	IMP	J:292035
Biological Process	GO:1905719	protein localization to perinuclear region of cytoplasm	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IMP	J:292035
Biological Process	GO:0071211	protein targeting to vacuole involved in autophagy	ISO	J:164563
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0061635	regulation of protein complex stability	ISO	J:164563
Biological Process	GO:0098780	response to mitochondrial depolarisation	ISO	J:164563
Biological Process	GO:0061912	selective autophagy	ISO	J:164563
Biological Process	GO:0001659	temperature homeostasis	IMP	J:292035
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:208209