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Pip5k1a
Gene Detail
 Symbol
Name
ID
Pip5k1a
phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
MGI:107929
Synonyms Pipk5a
Feature Type protein coding gene
Genetic Map
Chromosome 3
40.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:95058530-95106930 bp, - strand
From VEGA annotation of GRCm38

  48401 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:93492  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 zebrafish

Protein SuperFamily: phosphatidylinositol-4-phosphate 5-kinase type II alpha
Gene Tree: Pip5k1a

Human
homologs
Human Homolog PIP5K1A, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
NCBI Gene ID 8394
neXtProt AC  NX_Q99755
Human Chr (Location)  1q21.3; chr1:151198030-151249531 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(67) : Gene trapped(63) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
A gene trap insertion into an intron of this gene results in no obvious phenotype. Mice homozygous for a knock-out allele exhibit partial lethality and reduced male fertility associated with asthenozoospermia and abnormal midpiece morphology.
 
Interactions
Pip5k1a interacts with 260 markers (Mir10a, Mir17, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process actin cytoskeleton reorganization, activation of Rac GTPase activity, ...
Component cell projection, cytoplasm, ...
Function 1-phosphatidylinositol-4-phosphate 5-kinase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (275)    Tissues (132)    Images (46)
Theiler Stages: 22, 23, 28
Assay TypeResults
RNA in situ 274
Northern blot 1
cDNA source data(80)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(82) cDNA(80) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000019671 (Evidence)
Ensembl Gene ModelENSMUSG00000028126 (Evidence)
Entrez Gene18720 (Evidence)
UniGene296409
DFCITC1575576, TC1577989, TC1602459
DoTSDT.97367918, DT.99847473
NIA Mouse Gene IndexU024352
EC2.7.1.68
Consensus CDS ProjectCCDS38542.1
International Mouse Knockout Project StatusPip5k1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019671 VEGA Gene Model | MGI Sequence Detail 48401 C57BL/6J ±  kb
transcript OTTMUST00000047069 VEGA | MGI Sequence Detail 3663 Not Applicable 
polypeptide OTTMUSP00000021263 VEGA | MGI Sequence Detail 547 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(13) UniProt(3)
Polymorphisms SNPs within 2kb(146 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023610 Phosphatidylinositol-4-phosphate 5-kinase
InterPro IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core
InterPro IPR016034 Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup
InterPro IPR027483 Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
InterPro IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain
Protein Ontology PR:000012744 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
References (Earliest) J:35632 Ishihara H, et al., Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem. 1996 Sep 27;271(39):23611-4
(Latest) J:195855 Szalinski CM, et al., PIP5KIbeta selectively modulates apical endocytosis in polarized renal epithelial cells. PLoS One. 2013;8(1):e53790
All references(55)
Other
accession IDs
MGD-MRK-36509

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory