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Pip5k1a
Gene Detail
Symbol

Name
ID
Pip5k1a
phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
MGI:107929
Synonyms
Pipk5a
Feature Type
protein coding gene
Genetic Map
Chromosome 3
40.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:95058530-95106930 bp, - strand
From VEGA annotation of GRCm38

  48401 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:93492  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PIP5K1A
Protein SuperFamily: phosphatidylinositol-4-phosphate 5-kinase type II alpha
Gene Tree: Pip5k1a

Human
homologs
PIP5K1A, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8394
neXtProt AC: NX_Q99755

Human Chr (Location): 1q21.3; chr1:151197954-151249535 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(61) : Gene trapped(57) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
A gene trap insertion into an intron of this gene results in no obvious phenotype. Mice homozygous for a knock-out allele exhibit partial lethality and reduced male fertility associated with asthenozoospermia and abnormal midpiece morphology.
 
Interactions
Pip5k1a interacts with 260 markers (Mir10a, Mir17, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process actin cytoskeleton reorganization, activation of GTPase activity, ...
Component cell projection, cytoplasm, ...
Function 1-phosphatidylinositol-4-phosphate 5-kinase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (275)    Tissues (133)    Images (46)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 274
Northern blot 1
cDNA source data(80)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pip5k1a ; ZFIN pip5k1aa, pip5k1ab    NEW 
Molecular
reagents
All nucleic(82) cDNA(80) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000019671 (Evidence)
Ensembl Gene Model ENSMUSG00000028126 (Evidence)
Entrez Gene 18720 (Evidence)
UniGene 296409
DFCI TC1602459, TC1577989, TC1575576
DoTS DT.97367918, DT.99847473
NIA Mouse Gene Index U024352
EC 2.7.1.68
Consensus CDS Project CCDS38542.1
International Mouse Phenotyping Consortium Status Pip5k1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019671 VEGA Gene Model | MGI Sequence Detail 48401 C57BL/6J ±  kb
transcript OTTMUST00000047069 VEGA | MGI Sequence Detail 3663 Not Applicable 
polypeptide OTTMUSP00000021263 VEGA | MGI Sequence Detail 547 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(146 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023610 Phosphatidylinositol-4-phosphate 5-kinase
InterPro IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core
InterPro IPR016034 Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup
InterPro IPR027483 Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
InterPro IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain
Protein Ontology PR:000012744 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
References
(Earliest) J:35632 Ishihara H, et al., Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem. 1996 Sep 27;271(39):23611-4
(Latest) J:214303 Wright BD, et al., The lipid kinase PIP5K1C regulates pain signaling and sensitization. Neuron. 2014 May 21;82(4):836-47
All references(55)
Other
accession IDs
MGD-MRK-36509

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory