Pip5k1a
Gene Detail

Symbol Name ID

Pip5k1a phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha MGI:107929

Synonyms

Pipk5a

Feature Type

protein coding gene

Genetic Map

Chromosome 3

40.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr3:95058530-95106930 bp, - strand From VEGA annotation of GRCm38   48401 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Pip5k1a ± 2 cM)

Protein SuperFamily: phosphatidylinositol-4-phosphate 5-kinase type II alpha
Gene Tree: Pip5k1a

Human ortholog

PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha NCBI Gene ID 8394
Human Chr1:151171021-151222007 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(67) : Targeted(4) Gene trapped(63)
 

A gene trap insertion into an intron of this gene results in no obvious phenotype. Mice homozygous for a knock-out allele exhibit partial lethality and reduced male fertility associated with asthenozoospermia and abnormal midpiece morphology.

 

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	actin cytoskeleton reorganization, activation of Rac GTPase activity, ...
Component	cell projection, cytoplasm, ...
Function	1-phosphatidylinositol-4-phosphate 5-kinase activity, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (275)    Tissues (132)    Images (46)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	274
Northern blot	1

cDNA source data(80)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(82) cDNA(80) Primer pair(1) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000019671 (Evidence)
Ensembl Gene Model	ENSMUSG00000028126 (Evidence)
Entrez Gene	18720 (Evidence)
UniGene	296409
DFCI	TC1575576, TC1577989, TC1602459
DoTS	DT.97367918, DT.99847473
NIA Mouse Gene Index	U024352
EC	2.7.1.68
Consensus CDS Project	CCDS38542.1
International Mouse Knockout Project Status	Pip5k1a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019671	VEGA Gene Model | MGI Sequence Detail	48401	C57BL/6J
transcript	OTTMUST00000047069	VEGA | MGI Sequence Detail	3663	Not Applicable
polypeptide	OTTMUSP00000021263	VEGA | MGI Sequence Detail	547	Not Applicable

All sequences(53) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(115 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023610	Phosphatidylinositol-4-phosphate 5-kinase
InterPro	IPR002498	Phosphatidylinositol-4-phosphate 5-kinase, core
InterPro	IPR016034	Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup
Protein Ontology	PR:000012744	phosphatidylinositol-4-phosphate 5-kinase type-1 alpha

References

(Earliest) J:35632 Ishihara H, et al., Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem. 1996 Sep 27;271(39):23611-4
(Latest) J:185835 Hasegawa H, et al., Phosphatidylinositol 4-phosphate 5-kinase is indispensable for mouse spermatogenesis. Biol Reprod. 2012;86(5):136, 1-12
All references(54)

Other accession IDs

MGD-MRK-36509