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Pip5k1a Gene Detail
Summary
  • Symbol
    Pip5k1a
  • Name
    phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
  • Synonyms
    Pipk5a
  • Feature Type
    protein coding gene
  • IDs
    MGI:107929
    NCBI Gene: 18720
  • Gene Overview
    MyGene.info: PIP5K1A
Location & Maps
more
  • Sequence Map
    Chr3:95058530-95106930 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      48401 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.74 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PIP5K1A, phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PIP5K1A, phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 8394
    neXtProt AC: NX_Q99755

  • Chr Location
    1q21.3; chr1:151197954-151249535 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 3 alleles in 2 genetic backgrounds
    12 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    63
  • Chemically induced (other)
    1
  • Gene trapped
    57
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Pip5k1a
  • Incidental Mutations
A gene trap insertion into an intron of this gene results in no obvious phenotype. Mice homozygous for a knock-out allele exhibit partial lethality and reduced male fertility associated with asthenozoospermia and abnormal midpiece morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019671 VEGA Gene Model | MGI Sequence Detail 48401 C57BL/6J ±  kb
transcript OTTMUST00000047069 VEGA | MGI Sequence Detail 3663 Not Applicable  
polypeptide OTTMUSP00000021263 VEGA | MGI Sequence Detail 547 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    146 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000012744 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
  • EC
  • InterPro Domains
    IPR023610 Phosphatidylinositol-4-phosphate 5-kinase
    IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core
    IPR027483 Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
    IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain
Molecular
Reagents
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  • All nucleic 82
    cDNA 80
    Primer pair 1
    Other 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-36509
References
more
  • Summaries
    All 52
    Developmental Gene Expression 7
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:35632 Ishihara H, et al., Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem. 1996 Sep 27;271(39):23611-4
  • Latest
    J:214303 Wright BD, et al., The lipid kinase PIP5K1C regulates pain signaling and sensitization. Neuron. 2014 May 21;82(4):836-47

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory