Sequence Detail

ID/Version

P70182 Q3U917 Q99L80 F8WIX5 Q8K0D3 (UniProt | EBI)

Last sequence update: 2005-10-25
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha {ECO:0000305|PubMed:18772378, ECO:0000305|PubMed:8798574}; Short=PIP5K1-alpha {ECO:0000305|PubMed:18772378, ECO:0000305|PubMed:8798574}; Short=PtdIns(4)P-5-kinase 1 alpha

Provider

SWISS-PROT

Sequence

Polypeptide 546 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pip5k1a	phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha	44	102	4	52

Sequence references in MGI

J:35632 Ishihara H, et al., Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem. 1996 Sep 27;271(39):23611-4
J:46962 Ishihara H, et al., Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/ substitution analysis of members of this novel lipid kinase family. J Biol Chem. 1998 Apr 10;273(15):8741-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:139076 Wang Y, et al., Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14064-9
J:146157 Mao YS, et al., Essential and unique roles of PIP5K-gamma and -alpha in Fcgamma receptor-mediated phagocytosis. J Cell Biol. 2009 Jan 26;184(2):281-96
J:166299 Volpicelli-Daley LA, et al., Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain. J Biol Chem. 2010 Sep 10;285(37):28708-14
J:265618 Liu T, et al., A novel IRS-1-associated protein, DGKzeta regulates GLUT4 translocation in 3T3-L1 adipocytes. Sci Rep. 2016 Oct 14;6:35438
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89