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Aldh1a2
Gene Detail
 Symbol
Name
ID
Aldh1a2
aldehyde dehydrogenase family 1, subfamily A2
MGI:107928
Synonyms Aldh1a7, Raldh2, retinaldehyde dehydrogenase
Feature Type protein coding gene
Genetic Map
Chromosome 9
39.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:71215789-71296243 bp, + strand
From VEGA annotation of GRCm38

  80455 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68368  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: NAD-dependent aldehyde dehydrogenase
Gene Tree: Aldh1a2

Human
homologs
Human Homolog ALDH1A2, aldehyde dehydrogenase 1 family, member A2
NCBI Gene ID 8854
neXtProt AC  NX_O94788
Human Synonyms  RALDH2, RALDH2-T, RALDH(II)
Human Chr (Location)  15q21.3; chr15:57953424-58065923 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for null mutations are largely devoid of retinoic acid and die by embryonic day 10.5 with impaired hindbrain development, failure to turn, lack of limb buds, heart abnormalities, reduced otocysts and a truncated frontonasal region.
 
Human Diseases Modeled Using Mouse Aldh1a2 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(3)
Interactions
Aldh1a2 interacts with 137 markers (Mir23a, Mir23b, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (59 annotations)
Process 9-cis-retinoic acid biosynthetic process, anterior/posterior pattern specification, ...
Component cytoplasm, cytosol, ...
Function 3-chloroallyl aldehyde dehydrogenase activity, oxidoreductase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (175 records)
Data Summary: Results (589)    Tissues (416)    Images (197)
Theiler Stages: 7, 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 10
RNA in situ 512
Western blot 5
RT-PCR 62
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(38) cDNA(26) Primer pair(11) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000021057 (Evidence)
Ensembl Gene ModelENSMUSG00000013584 (Evidence)
Entrez Gene19378 (Evidence)
UniGene42016
DFCITC1583532
DoTSDT.40139240
NIA Mouse Gene IndexU010710
EC1.2.1.36
Consensus CDS ProjectCCDS52852.1
International Mouse Knockout Project StatusAldh1a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021057 VEGA Gene Model | MGI Sequence Detail 80455 C57BL/6J ±  kb
transcript OTTMUST00000049811 VEGA | MGI Sequence Detail 2264 Not Applicable 
polypeptide OTTMUSP00000023137 VEGA | MGI Sequence Detail 518 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms PCR(1) : SNPs within 2kb(506 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016160 Aldehyde dehydrogenase, conserved site
InterPro IPR016163 Aldehyde dehydrogenase, C-terminal
InterPro IPR015590 Aldehyde dehydrogenase domain
InterPro IPR016162 Aldehyde dehydrogenase, N-terminal
InterPro IPR016161 Aldehyde/histidinol dehydrogenase
Protein Ontology PR:000003921 retinal dehydrogenase 2
References (Earliest) J:73612 McCaffrery P, et al., Changing patterns of the retinoic acid system in the developing retina. Dev Biol. 1993 Aug;158(2):390-9
(Latest) J:207992 Chen F, et al., Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice. J Clin Invest. 2014 Feb 3;124(2):801-11
All references(252)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-36508, MGI:2143263

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory