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Aldh1a2
Gene Detail
Symbol

Name
ID
Aldh1a2
aldehyde dehydrogenase family 1, subfamily A2
MGI:107928
Synonyms
Aldh1a7, Raldh2, retinaldehyde dehydrogenase
Feature Type
protein coding gene
Genetic Map
Chromosome 9
39.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:71215789-71296243 bp, + strand
From VEGA annotation of GRCm38

  80455 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68368  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ALDH1A2
Protein SuperFamily: NAD-dependent aldehyde dehydrogenase
Gene Tree: Aldh1a2

Human
homologs
ALDH1A2, aldehyde dehydrogenase 1 family, member A2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8854
neXtProt AC: NX_O94788

Human Synonyms: RALDH2, RALDH2-T, RALDH(II)

Human Chr (Location): 15q21.3; chr15:57953424-58065923 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for null mutations are largely devoid of retinoic acid and die by embryonic day 10.5 with impaired hindbrain development, failure to turn, lack of limb buds, heart abnormalities, reduced otocysts and a truncated frontonasal region.
 
Human Diseases Modeled in Mice Using Aldh1a2 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(3)
Interactions
Aldh1a2 interacts with 136 markers (Mir23a, Mir23b, Mir27a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (189 records)
Data Summary: Results (592)    Tissues (418)    Images (199)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 515
Western blot 5
RT-PCR 62
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ALDH1A2 ; Xenbase aldh1a2 ; ZFIN aldh1a2    NEW 
Molecular
reagents
All nucleic(39) cDNA(27) Primer pair(11) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000021057 (Evidence)
Ensembl Gene Model ENSMUSG00000013584 (Evidence)
Entrez Gene 19378 (Evidence)
UniGene 42016
DFCI TC1583532
DoTS DT.40139240
NIA Mouse Gene Index U010710
EC 1.2.1.36
Consensus CDS Project CCDS52852.1
International Mouse Phenotyping Consortium Status Aldh1a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021057 VEGA Gene Model | MGI Sequence Detail 80455 C57BL/6J ±  kb
transcript OTTMUST00000049811 VEGA | MGI Sequence Detail 2264 Not Applicable 
polypeptide OTTMUSP00000023137 VEGA | MGI Sequence Detail 518 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(506 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016160 Aldehyde dehydrogenase, conserved site
InterPro IPR016163 Aldehyde dehydrogenase, C-terminal
InterPro IPR015590 Aldehyde dehydrogenase domain
InterPro IPR016162 Aldehyde dehydrogenase, N-terminal
InterPro IPR016161 Aldehyde/histidinol dehydrogenase
Protein Ontology PR:000003921 retinal dehydrogenase 2
References
(Earliest) J:73612 McCaffrery P, et al., Changing patterns of the retinoic acid system in the developing retina. Dev Biol. 1993 Aug;158(2):390-9
(Latest) J:220460 Andre P, et al., Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation. Development. 2015 Apr 15;142(8):1516-27
All references(268)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-36508, MGI:2143263

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory