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Rock1 Gene Detail
Summary
  • Symbol
    Rock1
  • Name
    Rho-associated coiled-coil containing protein kinase 1
  • Synonyms
    1110055K06Rik, Rock-I
  • Feature Type
    protein coding gene
  • IDs
    MGI:107927
    NCBI Gene: 19877
  • Gene Overview
    MyGene.info: ROCK1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr18:10064401-10181792 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      117392 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 4.91 cM, cytoband A2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ROCK1, Rho associated coiled-coil containing protein kinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ROCK1, Rho associated coiled-coil containing protein kinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    P160ROCK, ROCK-I
  • Links
    NCBI Gene ID: 6093
    neXtProt AC: NX_Q13464
    UniProt: Q13464

  • Chr Location
    18q11.1; chr18:20949740-21111851 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 7 alleles in 7 genetic backgrounds
    14 phenotypes from multigenic genotypes
    6 images
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice have open eyes at birth, omphalocele and most die soon after birth as a result of cannibalization by the mom. Survivors develop inflammation of the eyelid. Another homozygous mutant shows partial lethality around implantation and reduced cardiac fibrosis after pressure overload.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19877 NCBI Gene Model | MGI Sequence Detail 117392 C57BL/6J ±  kb
    transcript NM_009071 RefSeq | MGI Sequence Detail 6187 C57BL/6  
    polypeptide P70335 UniProt | EBI | MGI Sequence Detail 1354 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      379 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
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    • All nucleic 26
      cDNA 23
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-36507, MGI:1916035
    References
    more
    • Summaries
      All 148
      Developmental Gene Expression 27
      Gene Ontology 14
      Phenotypes 39
    • Earliest
      J:35061 Nakagawa O, et al., ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett. 1996 Aug 26;392(2):189-93
    • Latest
      J:261839 Shimizu T, et al., Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction. JCI Insight. 2017 Jul 6;2(13)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory