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Rock1
Gene Detail
Symbol

Name
ID
Rock1
Rho-associated coiled-coil containing protein kinase 1
MGI:107927
Synonyms
1110055K06Rik, Rock-I
Feature Type
protein coding gene
Genetic Map
Chromosome 18
4.91 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:10064401-10181792 bp, - strand
From NCBI annotation of GRCm38

  117392 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55899  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ROCK1
Protein SuperFamily: Rho-associated protein kinase
Gene Tree: Rock1

Human
homologs
ROCK1, Rho-associated, coiled-coil containing protein kinase 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6093
neXtProt AC: NX_Q13464

Human Synonyms: P160ROCK, ROCK-I

Human Chr (Location): 18q11.1; chr18:20949740-21111851 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(8) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice have open eyes at birth, omphalocele and most die soon after birth as a result of cannibalization by the mom. Survivors develop inflammation of the eyelid. Another homozygous mutant shows partial lethality around implantation and reduced cardiac fibrosis after pressure overload.
 
Phenotype Images(5)
Interactions
Rock1 interacts with 382 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process actin cytoskeleton organization, apical constriction, ...
Component cell projection, cytoplasm, ...
Function ATP binding, GTP-Rho binding, ...
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (26)    Tissues (18)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 15
Western blot 6
RT-PCR 3
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rock1 ; ZFIN rock1    NEW 
Molecular
reagents
All nucleic(22) cDNA(21) Primer pair(1)
Microarray probesets(7)
Other database
links
Ensembl Gene Model ENSMUSG00000024290 (Evidence)
Entrez Gene 19877 (Evidence)
DFCI TC1672903, TC1669644
DoTS DT.530567
NIA Mouse Gene Index U038201
EC 2.7.11.1
Consensus CDS Project CCDS29053.2
International Mouse Phenotyping Consortium Status Rock1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19877 NCBI Gene Model | MGI Sequence Detail 117392 C57BL/6J ±  kb
transcript NM_009071 RefSeq | MGI Sequence Detail 6187 C57BL/6 
polypeptide P70335 UniProt | EBI | MGI Sequence Detail 1354 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(5) UniProt(3)
Polymorphisms
SNPs within 2kb(381 from dbSNP Build 137)    SNPs within 2kb including multiple locations(383)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR011072 HR1 rho-binding repeat
InterPro IPR016253 Integrin-linked protein kinase
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR017892 Protein kinase, C-terminal
InterPro IPR011009 Protein kinase-like domain
InterPro IPR020684 Rho-associated protein kinase
InterPro IPR015008 Rho binding domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000000120 rho-associated protein kinase 1
Graphical View of Protein Domain Structure
References
(Earliest) J:35061 Nakagawa O, et al., ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett. 1996 Aug 26;392(2):189-93
(Latest) J:219576 McGreevy EM, et al., Shroom3 functions downstream of planar cell polarity to regulate myosin II distribution and cellular organization during neural tube closure. Biol Open. 2015;4(2):186-96
All references(107)
Other
accession IDs
MGD-MRK-36507, MGI:1916035

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory