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Rock1
Gene Detail
Symbol

Name
ID
Rock1
Rho-associated coiled-coil containing protein kinase 1
MGI:107927
Synonyms
1110055K06Rik, Rock-I
Feature Type
protein coding gene
Genetic Map
Chromosome 18
4.91 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:10064401-10181792 bp, - strand
From NCBI annotation of GRCm38

  117392 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55899  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Rho-associated protein kinase
Gene Tree: Rock1

Human
homologs
Human Homolog ROCK1, Rho-associated, coiled-coil containing protein kinase 1
NCBI Gene ID 6093
neXtProt AC  NX_Q13464
Human Synonyms  P160ROCK, ROCK-I
Human Chr (Location)  18q11.1; chr18:20949740-21111851 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(8) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have open eyes at birth, omphalocele and most die soon after birth as a result of cannibalization by the mom. Survivors develop inflammation of the eyelid. Another homozygous mutant shows partial lethality around implantation and reduced cardiac fibrosis after pressure overload.
 
Phenotype Images(5)
Interactions
Rock1 interacts with 383 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process actin cytoskeleton organization, apical constriction, ...
Component cell projection, cytoplasm, ...
Function ATP binding, GTP-Rho binding, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (26)    Tissues (18)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 15
Western blot 6
RT-PCR 3
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(21) Primer pair(1)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000024290 (Evidence)
Entrez Gene19877 (Evidence)
DFCITC1669644, TC1672903
DoTSDT.530567
NIA Mouse Gene IndexU038201
EC2.7.11.1
Consensus CDS ProjectCCDS29053.2
International Mouse Knockout Project StatusRock1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19877 NCBI Gene Model | MGI Sequence Detail 117392 C57BL/6J ±  kb
transcript NM_009071 RefSeq | MGI Sequence Detail 6187 C57BL/6 
polypeptide P70335 UniProt | EBI | MGI Sequence Detail 1354 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(381 from dbSNP Build 137)    SNPs within 2kb including multiple locations(383)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR011072 HR1 rho-binding repeat
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR017892 Protein kinase, C-terminal
InterPro IPR011009 Protein kinase-like domain
InterPro IPR020684 Rho-associated protein kinase
InterPro IPR015008 Rho binding domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000000120 rho-associated protein kinase 1
Graphical View of Protein Domain Structure
References
(Earliest) J:35061 Nakagawa O, et al., ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett. 1996 Aug 26;392(2):189-93
(Latest) J:208371 Lee SH, et al., ROCK1 isoform-specific deletion reveals a role for diet-induced insulin resistance. Am J Physiol Endocrinol Metab. 2014 Feb;306(3):E332-43
All references(106)
Other
accession IDs
MGD-MRK-36507, MGI:1916035

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory