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Rock1 Gene Detail
Summary
  • Symbol
    Rock1
  • Name
    Rho-associated coiled-coil containing protein kinase 1
  • Synonyms
    1110055K06Rik, Rock-I
  • Feature Type
    protein coding gene
  • IDs
    MGI:107927
    NCBI Gene: 19877
  • Gene Overview
    MyGene.info: ROCK1
Location & Maps
more
  • Sequence Map
    Chr18:10064401-10181792 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      117392 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 4.91 cM, cytoband A2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ROCK1, Rho associated coiled-coil containing protein kinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ROCK1, Rho associated coiled-coil containing protein kinase 1
    Orthology source: HomoloGene
  • Synonyms
    P160ROCK, ROCK-I
  • Links
    NCBI Gene ID: 6093
    neXtProt AC: NX_Q13464

  • Chr Location
    18q11.1; chr18:20949740-21111851 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 6 alleles in 6 genetic backgrounds
    14 phenotypes from multigenic genotypes
    6 images
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have open eyes at birth, omphalocele and most die soon after birth as a result of cannibalization by the mom. Survivors develop inflammation of the eyelid. Another homozygous mutant shows partial lethality around implantation and reduced cardiac fibrosis after pressure overload.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19877 NCBI Gene Model | MGI Sequence Detail 117392 C57BL/6J ±  kb
transcript NM_009071 RefSeq | MGI Sequence Detail 6187 C57BL/6  
polypeptide P70335 UniProt | EBI | MGI Sequence Detail 1354 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    379 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 25
    cDNA 22
    Primer pair 3

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-36507, MGI:1916035
References
more
  • Summaries
    All 111
    Developmental Gene Expression 24
    Gene Ontology 12
    Phenotypes 35
  • Earliest
    J:35061 Nakagawa O, et al., ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett. 1996 Aug 26;392(2):189-93
  • Latest
    J:229442 Kumper S, et al., Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis. Elife. 2016;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory