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Cd36 Gene Detail
Summary
  • Symbol
    Cd36
  • Name
    CD36 antigen
  • Synonyms
    FAT, fatty acid translocase, Scarb3
  • Feature Type
    protein coding gene
  • IDs
    MGI:107899
    NCBI Gene: 12491
  • Gene Overview
    MyGene.info: CD36
Location & Maps
more
  • Sequence Map
    Chr5:17782016-17888801 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      106786 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 8.11 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CD36, CD36 molecule
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CD36, CD36 molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3
  • Links
    NCBI Gene ID: 948
    neXtProt AC: NX_P16671

  • Chr Location
    7q11.2; chr7:80602188-80679277 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Cd36 mouse models; 3 with human CD36 associations

Human Disease Mouse Models
       Platelet Glycoprotein IV Deficiency   OMIM: 608404 View 1 model
       Pterygium of Conjunctiva and Cornea   OMIM: 178000 View 1 model
       Coronary Heart Disease, Susceptibility to, 7; CHDS7   OMIM: 610938
Malaria, Susceptibility to   OMIM: 611162
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    80 phenotypes from 4 alleles in 8 genetic backgrounds
    16 phenotypes from multigenic genotypes
    174 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    4 involving Cd36
  • Incidental Mutations
Homozygous mutant mice exhibit an immunodeficiency phenotype, are susceptible to S. aureus infection and develop ocular pterygium. Mice homozygous for disruptions in this gene display abnormal lipid homeostasis which affects energy utilization in the heart.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000053047 VEGA Gene Model | MGI Sequence Detail 106786 C57BL/6J ±  kb
transcript OTTMUST00000132689 VEGA | MGI Sequence Detail 2677 Not Applicable  
polypeptide OTTMUSP00000070715 VEGA | MGI Sequence Detail 472 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    761 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 17
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-36478
References
more
  • Summaries
    All 231
    Developmental Gene Expression 12
    Diseases 3
    Gene Ontology 22
    Phenotypes 174
  • Earliest
    J:14529 Fernandez-Ruiz E, et al., Gene encoding the collagen type I and thrombospondin receptor CD36 is located on chromosome 7q11.2. Genomics. 1993 Sep;17(3):759-61
  • Latest
    J:233618 Wilson CG, et al., Hepatocyte-Specific Disruption of CD36 Attenuates Fatty Liver and Improves Insulin Sensitivity in HFD-Fed Mice. Endocrinology. 2016 Feb;157(2):570-85

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory