Cd36
Gene Detail

Symbol Name ID

Cd36 CD36 antigen MGI:107899

Synonyms

FAT, fatty acid translocase, Scarb3

Feature Type

protein coding gene

Genetic Map

Chromosome 5

8.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr5:17781690-17888959 bp, - strand From NCBI annotation of GRCm38   107270 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:73871  Vertebrate Homology Class
1 human; 1 mouse; 3 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: lysosomal integral membrane protein II
Gene Tree: Cd36

Human homologs

Human Homolog		CD36, CD36 molecule (thrombospondin receptor)
NCBI Gene ID		948
neXtProt AC		NX_P16671
Human Synonyms		BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3
Human Chr (Location)		7q11.2; chr7:80231504-80308593 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human CD36

Alleles and phenotypes

All alleles(5) : Targeted(4) Chemically induced(1)
 

Homozygous mutant mice exhibit an immunodeficiency phenotype, are susceptible to S. aureus infection and develop ocular pterygium. Mice homozygous for disruptions in this gene display abnormal lipid homeostasis which affects energy utilization in the heart.

 
Human Diseases Modeled Using Mouse Cd36 (2)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (85 annotations)

Process	apoptotic cell clearance, cell adhesion, ...
Component	apical part of cell, caveola, ...
Function	high-density lipoprotein particle binding, lipid binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (142)    Tissues (20)    Images (31)
Theiler Stages: 13, 21, 23

Assay Type	Results
Immunohistochemistry	2
RNA in situ	140

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000002944 (Evidence)
Entrez Gene	12491 (Evidence)
DFCI	TC1572685, TC1649855, TC1666617, TC1701030, TC1741221
DoTS	DT.101247870, DT.101280882, DT.101408146, DT.495493
NIA Mouse Gene Index	U143585
Consensus CDS Project	CCDS19100.1
International Mouse Knockout Project Status	Cd36

Sequences

Length	Strain/Species
genomic	12491	NCBI Gene Model | MGI Sequence Detail	107270	C57BL/6J
transcript	NM_001159558	RefSeq | MGI Sequence Detail	3566	C57BL/6
polypeptide	Q08857	UniProt | EBI | MGI Sequence Detail	472	Not Applicable

All sequences(59) RefSeq(10) UniProt(8)

Polymorphisms

SNPs(246 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005428	Adhesion molecule CD36
InterPro	IPR002159	CD36 antigen
Protein Ontology	PR:000001905	platelet glycoprotein 4

Graphical View of Protein Domain Structure

References

(Earliest) J:14529 Fernandez-Ruiz E, et al., Gene encoding the collagen type I and thrombospondin receptor CD36 is located on chromosome 7q11.2. Genomics. 1993 Sep;17(3):759-61
(Latest) J:195083 Wan Z, et al., FAT/CD36 regulates PEPCK expression in adipose tissue. Am J Physiol Cell Physiol. 2013 Mar 1;304(5):C478-84
All references(181)

Other accession IDs

MGD-MRK-36478