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Exosc5 Gene Detail
Summary
  • Symbol
    Exosc5
  • Name
    exosome component 5
  • Synonyms
    D7Wsu180e
  • Feature Type
    protein coding gene
  • IDs
    MGI:107889
    NCBI Gene: 27998
  • Gene Overview
    MyGene.info: EXOSC5
Location & Maps
more
  • Sequence Map
    Chr7:25659164-25671368 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12205 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 13.96 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    EXOSC5, exosome component 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EXOSC5, exosome component 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hRrp46p, p12B, RRP41B, RRP46, Rrp46p
  • Links
    NCBI Gene ID: 56915
    neXtProt AC: NX_Q9NQT4

  • Chr Location
    19q13.1; chr19:41386370-41397351 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 5981
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: EXOSC5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    38
  • Gene trapped
    36
  • Targeted
    2
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058396 VEGA Gene Model | MGI Sequence Detail 12205 C57BL/6J ±  kb
transcript OTTMUST00000143426 VEGA | MGI Sequence Detail 1020 Not Applicable  
polypeptide OTTMUSP00000074773 VEGA | MGI Sequence Detail 235 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    76 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000007262 exosome complex component RRP46
  • InterPro Domains
    IPR001247 Exoribonuclease, phosphorolytic domain 1
    IPR015847 Exoribonuclease, phosphorolytic domain 2
    IPR027408 PNPase/RNase PH domain
    IPR020568 Ribosomal protein S5 domain 2-type fold
Molecular
Reagents
less
  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36466
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:47941 Jaradat SA, et al., Tissue-specific expression and mapping of the Cox7ah gene in mouse (Erratum: 1998;54(3):583-4). Genomics. 1998 May 1;49(3):363-70
  • Latest
    J:173556 Flynn RA, et al., Antisense RNA polymerase II divergent transcripts are P-TEFb dependent and substrates for the RNA exosome. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10460-5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory