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Exosc5
Gene Detail
Symbol

Name
ID
Exosc5
exosome component 5
MGI:107889
Synonyms
D7Wsu180e
Feature Type
protein coding gene
Genetic Map
Chromosome 7
13.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr7:25659153-25668031 bp, + strand
From Ensembl annotation of GRCm38

  8879 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5981  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Exosc5

Human
homologs
Human Homolog EXOSC5, exosome component 5
NCBI Gene ID 56915
neXtProt AC  NX_Q9NQT4
Human Synonyms  hRrp46p, p12B, RRP41B, RRP46, Rrp46p
Human Chr (Location)  19q13.1; chr19:41386370-41397351 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(36) Targeted(2)
Interactions
Exosc5 interacts with 15 markers (Mir129-1, Mir129-2, Mir149, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process defense response to virus, DNA deamination, ...
Component cytoplasm, exosome (RNase complex), ...
Function RNA binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (6)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 6
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000061286 (Evidence)
Entrez Gene27998 (Evidence)
NIA Mouse Gene IndexU241988, U327395
Consensus CDS ProjectCCDS20990.1
International Mouse Knockout Project StatusExosc5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061286 Ensembl Gene Model | MGI Sequence Detail 8879 C57BL/6J ±  kb
transcript ENSMUST00000079634 Ensembl | MGI Sequence Detail 1030 Not Applicable 
polypeptide ENSMUSP00000078580 Ensembl | MGI Sequence Detail 235 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(3) UniProt(2)
Polymorphisms
SNPs within 2kb(63 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001247 Exoribonuclease, phosphorolytic domain 1
InterPro IPR015847 Exoribonuclease, phosphorolytic domain 2
InterPro IPR027408 PNPase/RNase PH domain
InterPro IPR020568 Ribosomal protein S5 domain 2-type fold
Protein Ontology PR:000007262 exosome complex component RRP46
References
(Earliest) J:47941 Jaradat SA, et al., Tissue-specific expression and mapping of the Cox7ah gene in mouse (Erratum: 1998;54(3):583-4). Genomics. 1998 May 1;49(3):363-70
(Latest) J:173556 Flynn RA, et al., Antisense RNA polymerase II divergent transcripts are P-TEFb dependent and substrates for the RNA exosome. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10460-5
All references(36)
Other
accession IDs
MGD-MRK-36466

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory