About   Help   FAQ
Pfkfb2 Gene Detail
Summary
  • Symbol
    Pfkfb2
  • Name
    6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
  • Synonyms
    4930568D07Rik, PFK-2/FBPase-2 gene B
  • Feature Type
    protein coding gene
  • IDs
    MGI:107815
    NCBI Gene: 18640
  • Gene Overview
    MyGene.info: PFKFB2
Location & Maps
more
  • Sequence Map
    Chr1:130689182-130729253 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40072 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 56.89 cM, cytoband E4
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PFKFB2, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PFKFB2, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PFK-2/FBPase-2
  • Links
    NCBI Gene ID: 5208
    neXtProt AC: NX_O60825

  • Chr Location
    1q32.1; chr1:207034416-207081023 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Pfkfb2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049608 VEGA Gene Model | MGI Sequence Detail 40072 C57BL/6J ±  kb
transcript OTTMUST00000126401 VEGA | MGI Sequence Detail 1759 Not Applicable  
polypeptide OTTMUSP00000068360 VEGA | MGI Sequence Detail 556 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    295 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 60
    cDNA 59
    Primer pair 1

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-36392, MGI:1923175
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:35365 Batra RS, et al., Molecular cloning and tissue-specific expression of mouse kidney 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. FEBS Lett. 1996 Sep 16;393(2-3):167-73
  • Latest
    J:218247 Cossette SM, et al., Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism. Biol Open. 2014;4(1):48-61

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/29/2016
MGI 6.06
The Jackson Laboratory