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Tubb5 Gene Detail
Summary
  • Symbol
    Tubb5
  • Name
    tubulin, beta 5 class I
  • Synonyms
    B130022C14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:107812
    NCBI Gene: 22154
  • Gene Overview
    MyGene.info: TUBB
Location & Maps
more
  • Sequence Map
    Chr17:35833921-35838306 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4386 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.70 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    TUBB, tubulin beta class I
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TUBB, tubulin beta class I
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDCBM6, CSCSC1, M40, OK/SW-cl.56, TUBB1, TUBB5
  • Links
    NCBI Gene ID: 203068
    neXtProt AC: NX_P07437

  • Chr Location
    6p21.33; chr6:30720201-30725426 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 69099
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TUBB
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human TUBB associations

Human Disease Mouse Models
       Cortical Dysplasia, Complex, with Other Brain Malformations 6; CDCBM6   OMIM: 615771
Skin Creases, Congenital Symmetric Circumferential, 1; CSCSC1   OMIM: 156610
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    15
  • Gene trapped
    11
  • Targeted
    4
  • Genomic Mutations
    1 involving Tubb5
  • Incidental Mutations
    APF , CvDC
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026311 VEGA Gene Model | MGI Sequence Detail 4386 C57BL/6J ±  kb
transcript OTTMUST00000065077 VEGA | MGI Sequence Detail 2649 Not Applicable  
polypeptide OTTMUSP00000032384 VEGA | MGI Sequence Detail 444 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 53
    cDNA 46
    Primer pair 5
    Other 2

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-36389, MGI:2146752, MGI:2146893, MGI:2442353
References
more
  • Summaries
    All 54
    Developmental Gene Expression 11
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:19085 Lewis SA, et al., Five mouse tubulin isotypes and their regulated expression during development. J Cell Biol. 1985 Sep;101(3):852-61
  • Latest
    J:214318 Ngo L, et al., TUBB5 and its disease-associated mutations influence the terminal differentiation and dendritic spine densities of cerebral cortical neurons. Hum Mol Genet. 2014 Oct 1;23(19):5147-58

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory