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Gadd45a
Gene Detail
 Symbol
Name
ID
Gadd45a
growth arrest and DNA-damage-inducible 45 alpha
MGI:107799
Synonyms Ddit1
Feature Type protein coding gene
Genetic Map
Chromosome 6
30.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr6:67035096-67037457 bp, - strand
From VEGA annotation of GRCm38

  2362 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1449  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: growth arrest and DNA-damage-inducible protein GADD45
Gene Tree: Gadd45a

Human
homologs
Human Homolog GADD45A, growth arrest and DNA-damage-inducible, alpha
NCBI Gene ID 1647
neXtProt AC  NX_P24522
Human Synonyms  DDIT1, GADD45
Human Chr (Location)  1p31.2; chr1:67685177-67688338 (+)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(2) Gene trapped(1)
 
Homozygous null mice show genomic instability, thymus hyperplasia, elevated radiation carcinogenesis, abnormal parturition and low frequency exencephaly. Females develop a lupus-like syndrome associated with high titers of autoantibodies, hematologic deficits, glomerulonephritis and premature death.
 
Human Diseases Modeled Using Mouse Gadd45a (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process activation of MAPKKK activity, cell cycle, ...
Component cytoplasm, nucleus
Function core promoter binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (109)    Tissues (39)    Images (39)
Theiler Stages: 9, 11, 13, 14, 15, 17, 23, 28
Assay TypeResults
RNA in situ 101
RT-PCR 8
cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(37) Genomic(2) cDNA(31) Primer pair(4)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000023157 (Evidence)
Ensembl Gene ModelENSMUSG00000036390 (Evidence)
Entrez Gene13197 (Evidence)
UniGene72235
DFCITC1583451
Consensus CDS ProjectCCDS20217.1
International Mouse Knockout Project StatusGadd45a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023157 VEGA Gene Model | MGI Sequence Detail 2362 C57BL/6J ±  kb
transcript OTTMUST00000055990 VEGA | MGI Sequence Detail 1223 Not Applicable 
polypeptide OTTMUSP00000026869 VEGA | MGI Sequence Detail 165 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(21 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024824 Growth arrest and DNA damage-inducible protein GADD45
InterPro IPR004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45
Protein Ontology PR:000007787 growth arrest and DNA damage-inducible protein GADD45 alpha
References (Earliest) J:43671 Hollander MC, et al., Analysis of the mammalian gadd45 gene and its response to DNA damage. J Biol Chem. 1993 Nov 15;268(32):24385-93
(Latest) J:199917 Johnen H, et al., Gadd45g is essential for primary sex determination, male fertility and testis development. PLoS One. 2013;8(3):e58751
All references(79)
Other
accession IDs
MGD-MRK-36376, MGI:2141368

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory