Gadd45a
Gene Detail

Symbol Name ID

Gadd45a growth arrest and DNA-damage-inducible 45 alpha MGI:107799

Synonyms

Ddit1

Feature Type

protein coding gene

Genetic Map

Chromosome 6

30.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr6:67035096-67037457 bp, - strand From VEGA annotation of GRCm38   2362 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1449  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: growth arrest and DNA-damage-inducible protein GADD45
Gene Tree: Gadd45a

Human homologs

Human Homolog		GADD45A, growth arrest and DNA-damage-inducible, alpha
NCBI Gene ID		1647
neXtProt AC		NX_P24522
Human Synonyms		DDIT1, GADD45
Human Chr (Location)		1p31.2; chr1:68150860-68154021 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Homozygous null mice show genomic instability, thymus hyperplasia, elevated radiation carcinogenesis, abnormal parturition and low frequency exencephaly. Females develop a lupus-like syndrome associated with high titers of autoantibodies, hematologic deficits, glomerulonephritis and premature death.

 
Human Diseases Modeled Using Mouse Gadd45a (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	cell cycle, cell cycle arrest, ...
Component	nucleus
Function	core promoter binding, protein binding

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (107)    Tissues (38)    Images (39)
Theiler Stages: 9, 11, 13, 14, 15, 17, 23

Assay Type	Results
RNA in situ	101
RT-PCR	6

cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) Genomic(2) cDNA(4) Primer pair(3)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000023157 (Evidence)
Ensembl Gene Model	ENSMUSG00000036390 (Evidence)
Entrez Gene	13197 (Evidence)
DFCI	TC1583451
Consensus CDS Project	CCDS20217.1
International Mouse Knockout Project Status	Gadd45a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023157	VEGA Gene Model | MGI Sequence Detail	2362	C57BL/6J
transcript	OTTMUST00000055990	VEGA | MGI Sequence Detail	1223	Not Applicable
polypeptide	OTTMUSP00000026869	VEGA | MGI Sequence Detail	165	Not Applicable

All sequences(27) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(19 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024824	Growth arrest and DNA damage-inducible protein GADD45
InterPro	IPR004038	Ribosomal protein L7Ae/L30e/S12e/Gadd45
Protein Ontology	PR:000007787	growth arrest and DNA damage-inducible protein GADD45 alpha

References

(Earliest) J:43671 Hollander MC, et al., Analysis of the mammalian gadd45 gene and its response to DNA damage. J Biol Chem. 1993 Nov 15;268(32):24385-93
(Latest) J:191765 Sarkisian MR, et al., Abnormal levels of Gadd45alpha in developing neocortex impair neurite outgrowth. PLoS One. 2012;7(9):e44207
All references(73)

Other accession IDs

MGD-MRK-36376, MGI:2141368