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Gadd45a Gene Detail
Summary
  • Symbol
    Gadd45a
  • Name
    growth arrest and DNA-damage-inducible 45 alpha
  • Synonyms
    Ddit1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107799
    NCBI Gene: 13197
  • Gene Overview
    MyGene.info: GADD45A
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:67035096-67037457 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2362 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 30.72 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    GADD45A, growth arrest and DNA damage inducible alpha
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GADD45A, growth arrest and DNA damage inducible alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DDIT1, GADD45
  • Links
    NCBI Gene ID: 1647
    neXtProt AC: NX_P24522
    UniProt: P24522

  • Chr Location
    1p31.3; chr1:67685177-67688338 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Gadd45a mouse models

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 1 allele in 3 genetic backgrounds
    36 phenotypes from multigenic genotypes
    2 images
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show genomic instability, thymus hyperplasia, elevated radiation carcinogenesis, abnormal parturition and low frequency exencephaly. Females develop a lupus-like syndrome associated with high titers of autoantibodies, hematologic deficits, glomerulonephritis and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023157 VEGA Gene Model | MGI Sequence Detail 2362 C57BL/6J ±  kb
    transcript OTTMUST00000055990 VEGA | MGI Sequence Detail 1223 Not Applicable  
    polypeptide OTTMUSP00000026869 VEGA | MGI Sequence Detail 165 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      21 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000007787 growth arrest and DNA damage-inducible protein GADD45 alpha
    • InterPro Domains
      IPR029064 50S ribosomal protein L30e-like
      IPR024824 Growth arrest and DNA damage-inducible protein GADD45
      IPR004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45
    Molecular
    Reagents
    less
    • All nucleic 42
      Genomic 2
      cDNA 32
      Primer pair 7
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-36376, MGI:2141368
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 17
      Diseases 2
      Gene Ontology 8
      Phenotypes 31
    • Earliest
      J:43671 Hollander MC, et al., Analysis of the mammalian gadd45 gene and its response to DNA damage. J Biol Chem. 1993 Nov 15;268(32):24385-93
    • Latest
      J:257918 Massimino L, et al., TBR2 antagonizes retinoic acid dependent neuronal differentiation by repressing Zfp423 during corticogenesis. Dev Biol. 2018 Feb 15;434(2):231-248

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory