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Gadd45a Gene Detail
Summary
  • Symbol
    Gadd45a
  • Name
    growth arrest and DNA-damage-inducible 45 alpha
  • Synonyms
    Ddit1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107799
    NCBI Gene: 13197
  • Gene Overview
    MyGene.info: GADD45A
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:67035096-67037407 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 30.72 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    21 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107799
protein coding gene Chr6:67035096-67037457 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030843
protein coding gene Chr6:67005268-67007629 (-)
A/J MGP_AJ_G0030813
protein coding gene Chr6:64116209-64118570 (-)
AKR/J MGP_AKRJ_G0030741
protein coding gene Chr6:66123626-66125987 (-)
BALB/cJ MGP_BALBcJ_G0030824
protein coding gene Chr6:64491479-64493840 (-)
C3H/HeJ MGP_C3HHeJ_G0030888
protein coding gene Chr6:118019846-118022207 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031282
protein coding gene Chr6:68605733-68608094 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028471
protein coding gene Chr6:61292738-61295114 (-)
CAST/EiJ MGP_CASTEiJ_G0029932
protein coding gene Chr6:66405923-66411099 (-)
CBA/J MGP_CBAJ_G0030511
protein coding gene Chr6:71428532-71430893 (-)
DBA/2J MGP_DBA2J_G0030663
protein coding gene Chr6:63774912-63777273 (-)
FVB/NJ MGP_FVBNJ_G0030616
protein coding gene Chr6:63284500-63286861 (-)
LP/J MGP_LPJ_G0030742
protein coding gene Chr6:66936629-66938990 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030651
protein coding gene Chr6:75139496-75141854 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031308
protein coding gene Chr6:66040335-66042693 (-)
PWK/PhJ MGP_PWKPhJ_G0029647
protein coding gene Chr6:62970818-62976370 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029476
protein coding gene Chr6:65608599-65613875 (-)
WSB/EiJ MGP_WSBEiJ_G0030014
protein coding gene Chr6:66360928-66363289 (-)



Homology
more
  • Human Ortholog
    GADD45A, growth arrest and DNA damage inducible alpha
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GADD45A, growth arrest and DNA damage inducible alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DDIT1, GADD45
  • Links
    NCBI Gene ID: 1647
    neXtProt AC: NX_P24522
    UniProt: P24522

  • Chr Location
    1p31.3; chr1:67685177-67688338 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Gadd45a mouse models

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 1 allele in 3 genetic backgrounds
    36 phenotypes from multigenic genotypes
    2 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice show genomic instability, thymus hyperplasia, elevated radiation carcinogenesis, abnormal parturition and low frequency exencephaly. Females develop a lupus-like syndrome associated with high titers of autoantibodies, hematologic deficits, glomerulonephritis and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13197 NCBI Gene Model | MGI Sequence Detail 2312 C57BL/6J ±  kb
    transcript NM_007836 RefSeq | MGI Sequence Detail 1224 129/Sv  
    polypeptide P48316 UniProt | EBI | MGI Sequence Detail 165 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000007787 growth arrest and DNA damage-inducible protein GADD45 alpha
    • InterPro Domains
      IPR029064 50S ribosomal protein L30e-like
      IPR024824 Growth arrest and DNA damage-inducible protein GADD45
      IPR004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45
    Molecular
    Reagents
    less
    • All nucleic 42
      Genomic 2
      cDNA 32
      Primer pair 7
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-36376, MGI:2141368
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 17
      Diseases 2
      Gene Ontology 8
      Phenotypes 32
    • Earliest
      J:43671 Hollander MC, et al., Analysis of the mammalian gadd45 gene and its response to DNA damage. J Biol Chem. 1993 Nov 15;268(32):24385-93
    • Latest
      J:265926 Diao D, et al., Telomeric epigenetic response mediated by Gadd45a regulates stem cell aging and lifespan. EMBO Rep. 2018 Oct;19(10)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory