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Gadd45b
Gene Detail
 Symbol
Name
ID
Gadd45b
growth arrest and DNA-damage-inducible 45 beta
MGI:107776
Synonyms Myd118
Feature Type protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:80930091-80932204 bp, + strand
From NCBI annotation of GRCm38

  2114 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7433  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: growth arrest and DNA-damage-inducible protein GADD45
Gene Tree: Gadd45b

Human
homologs
Human Homolog GADD45B, growth arrest and DNA-damage-inducible, beta
NCBI Gene ID 4616
neXtProt AC  NX_O75293
Human Synonyms  GADD45BETA, MYD118
Human Chr (Location)  19p13.3; chr19:2476125-2478259 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(5) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this locus affects immune response.
 
Interactions
Gadd45b interacts with 41 markers (Mir1a-1, Mir1a-2, Mir92-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process activation of MAPKK activity, activation of MAPKKK activity, ...
Component cytoplasm, nucleus
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (93)    Tissues (45)    Images (37)
Theiler Stages: 9, 11, 13, 14, 15, 17, 23
Assay TypeResults
RNA in situ 86
RT-PCR 7
cDNA source data(58)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(62) cDNA(58) Primer pair(4)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000015312 (Evidence)
Entrez Gene17873 (Evidence)
UniGene1360
DFCITC1579606
DoTSDT.534441
NIA Mouse Gene IndexU011769
Consensus CDS ProjectCCDS24038.1
International Mouse Knockout Project StatusGadd45b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17873 NCBI Gene Model | MGI Sequence Detail 2114 C57BL/6J ±  kb
transcript NM_008655 RefSeq | MGI Sequence Detail 1305 Not Specified 
polypeptide P22339 UniProt | EBI | MGI Sequence Detail 160 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Protein-related
information
ResourceIDDescription
InterPro IPR024824 Growth arrest and DNA damage-inducible protein GADD45
InterPro IPR004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45
Protein Ontology PR:000007788 growth arrest and DNA damage-inducible protein GADD45 beta
Graphical View of Protein Domain Structure
References (Earliest) J:43420 Abdollahi A, et al., Sequence and expression of a cDNA encoding MyD118: a novel myeloid differentiation primary response gene induced by multiple cytokines. Oncogene. 1991 Jan;6(1):165-7
(Latest) J:205624 Keil E, et al., Phosphorylation of Atg5 by the Gadd45beta-MEKK4-p38 pathway inhibits autophagy. Cell Death Differ. 2013 Feb;20(2):321-32
All references(59)
Other
accession IDs
MGD-MRK-36353, MGI:2143576

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory