About   Help   FAQ
Gadd45b
Gene Detail
Symbol

Name
ID
Gadd45b
growth arrest and DNA-damage-inducible 45 beta
MGI:107776
Synonyms
Myd118
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:80930091-80932204 bp, + strand
From NCBI annotation of GRCm38

  2114 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7433  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: GADD45B
Protein SuperFamily: growth arrest and DNA-damage-inducible protein GADD45
Gene Tree: Gadd45b

Human
homologs
GADD45B, growth arrest and DNA-damage-inducible, beta
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4616
neXtProt AC: NX_O75293

Human Synonyms: GADD45BETA, MYD118

Human Chr (Location): 19p13.3; chr19:2476125-2478259 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(5) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this locus affects immune response.
 
Interactions
Gadd45b interacts with 41 markers (Mir1a-1, Mir1a-2, Mir92-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process activation of MAPKK activity, activation of MAPKKK activity, ...
Component cytoplasm, nucleus
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (93)    Tissues (45)    Images (37)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 86
RT-PCR 7
cDNA source data(58)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gadd45b ; ZFIN gadd45ba, gadd45bb    NEW 
Molecular
reagents
All nucleic(62) cDNA(58) Primer pair(4)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000015312 (Evidence)
Entrez Gene 17873 (Evidence)
UniGene 1360
DFCI TC1579606
DoTS DT.534441
NIA Mouse Gene Index U011769
Consensus CDS Project CCDS24038.1
International Mouse Phenotyping Consortium Status Gadd45b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17873 NCBI Gene Model | MGI Sequence Detail 2114 C57BL/6J ±  kb
transcript NM_008655 RefSeq | MGI Sequence Detail 1305 Not Specified 
polypeptide P22339 UniProt | EBI | MGI Sequence Detail 160 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Protein-related
information
ResourceIDDescription
InterPro IPR024824 Growth arrest and DNA damage-inducible protein GADD45
InterPro IPR004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45
Protein Ontology PR:000007788 growth arrest and DNA damage-inducible protein GADD45 beta
Graphical View of Protein Domain Structure
References
(Earliest) J:43420 Abdollahi A, et al., Sequence and expression of a cDNA encoding MyD118: a novel myeloid differentiation primary response gene induced by multiple cytokines. Oncogene. 1991 Jan;6(1):165-7
(Latest) J:221453 Matsunaga E, et al., Comparative analysis of developmentally regulated expressions of Gadd45a, Gadd45b, and Gadd45g in the mouse and marmoset cerebral cortex. Neuroscience. 2015 Jan 22;284:566-80
All references(59)
Other
accession IDs
MGD-MRK-36353, MGI:2143576

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/28/2015
MGI 5.22
The Jackson Laboratory