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Casp3
Gene Detail
Symbol

Name
ID
Casp3
caspase 3
MGI:107739
Synonyms
A830040C14Rik, AC-3, Apopain, Caspase-3, CC3, CPP32, mldy, Yama
Feature Type
protein coding gene
Genetic Map
Chromosome 8
26.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr8:46617449-46638706 bp, + strand
From Ensembl annotation of GRCm38

  21258 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37912  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: caspase-3, 6, 7
Gene Tree: Casp3

Human
homologs
Human Homolog CASP3, caspase 3, apoptosis-related cysteine peptidase
NCBI Gene ID 836
neXtProt AC  NX_P42574
Human Synonyms  CPP32, CPP32B, SCA-1
Human Chr (Location)  4q34; chr4:184627696-184649475 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Chemically induced (ENU)(2) Gene trapped(6) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Some homozygous animals show defects in brain development by embryonic day 12, reduced neuronal apoptosis causing hyperplasias, and pre- and postnatal lethality. Other homozygous animals exhibit only hearing loss, inner ear defects and degeneration of spiral ganglion neurons.
 
Phenotype Images(1)
Interactions
Casp3 interacts with 96 markers (Mir7-1, Mir23a, Mir26a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (82 annotations)
Process apoptotic process, B cell homeostasis, ...
Component cytoplasm, cytosol, ...
Function aspartic-type endopeptidase activity, cyclin-dependent protein serine/threonine kinase inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (971 records)
Data Summary: Results (277)    Tissues (123)    Images (86)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 156
RNA in situ 73
Western blot 39
RT-PCR 4
RNase protection 5
cDNA source data(62)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(78) Genomic(5) cDNA(64) Primer pair(8) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000031628 (Evidence)
Entrez Gene12367 (Evidence)
UniGene34405
DFCITC1583881, TC1682602, TC1593094
DoTSDT.60104513, DT.492850
NIA Mouse Gene IndexU009318
EC3.4.22.56
Consensus CDS ProjectCCDS22294.1
International Mouse Knockout Project StatusCasp3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031628 Ensembl Gene Model | MGI Sequence Detail 21258 C57BL/6J ±  kb
transcript ENSMUST00000093517 Ensembl | MGI Sequence Detail 1455 Not Applicable 
polypeptide ENSMUSP00000091238 Ensembl | MGI Sequence Detail 277 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(3)
Polymorphisms
All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(280 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015470 Caspase-3
InterPro IPR011600 Peptidase C14, caspase catalytic
InterPro IPR002138 Peptidase C14, caspase non-catalytic subunit p10
InterPro IPR015917 Peptidase C14, caspase precursor p45, core
InterPro IPR001309 Peptidase C14, ICE, catalytic subunit p20
InterPro IPR016129 Peptidase C14, ICE, catalytic subunit p20, active site
Protein Ontology PR:000002312 caspase-3
References
(Earliest) J:34911 Juan TS, et al., Molecular characterization of mouse and rat CPP32 beta gene encoding a cysteine protease resembling interleukin-1 beta converting enzyme and CED-3. Oncogene. 1996 Aug 15;13(4):749-55
(Latest) J:212712 Liang G, et al., Endoplasmic reticulum stress-unfolding protein response-apoptosis cascade causes chondrodysplasia in a col2a1 p.Gly1170Ser mutated mouse model. PLoS One. 2014;9(1):e86894
All references(1177)
Other
accession IDs
MGD-MRK-36315, MGI:2442726, MGI:3717434

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory