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Casp3 Gene Detail
Summary
  • Symbol
    Casp3
  • Name
    caspase 3
  • Synonyms
    A830040C14Rik, AC-3, Apopain, Caspase-3, CC3, CPP32, mldy, Yama
  • Feature Type
    protein coding gene
  • IDs
    MGI:107739
    NCBI Gene: 12367
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:47070326-47092724 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 26.39 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    276 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107739
 protein coding gene Chr8:47070326-47092733 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033591
 protein coding gene Chr8:45725060-45749868 (+)
A/J MGP_AJ_G0033573
 protein coding gene Chr8:43978191-44000386 (+)
AKR/J MGP_AKRJ_G0033498
 protein coding gene Chr8:45257485-45278103 (+)
BALB/cJ MGP_BALBcJ_G0033570
 protein coding gene Chr8:44141582-44163921 (+)
C3H/HeJ MGP_C3HHeJ_G0033279
 protein coding gene Chr8:45784355-45806668 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034086
 protein coding gene Chr8:47457971-47485344 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031035
 protein coding gene Chr8:40210206-40230652 (+)
CAST/EiJ MGP_CASTEiJ_G0032605
 protein coding gene Chr8:45224912-45249279 (+)
CBA/J MGP_CBAJ_G0033258
 protein coding gene Chr8:49345667-49369353 (+)
DBA/2J MGP_DBA2J_G0033411
 protein coding gene Chr8:43767782-43790250 (+)
FVB/NJ MGP_FVBNJ_G0033352
 protein coding gene Chr8:43245763-43268771 (+)
LP/J MGP_LPJ_G0033499
 protein coding gene Chr8:45740815-45763012 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033397
 protein coding gene Chr8:49443177-49467359 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034104
 protein coding gene Chr8:45409930-45434072 (+)
PWK/PhJ MGP_PWKPhJ_G0032313
 protein coding gene Chr8:43295472-43317948 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032149
 protein coding gene Chr8:44578883-44600871 (+)
WSB/EiJ MGP_WSBEiJ_G0032721
 protein coding gene Chr8:45675374-45698823 (+)



Homology
more
  • Human Ortholog
    CASP3, caspase 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CASP3, caspase 3
  • Synonyms
    CPP32, CPP32B, SCA-1
  • Links
    NCBI Gene ID: 836
    neXtProt AC: NX_P42574
    UniProt: P42574

  • Chr Location
    4q35.1; chr4:184627696-184650062 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human CASP3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    82 phenotypes from 7 alleles in 10 genetic backgrounds
    27 phenotypes from multigenic genotypes
    1 images
    144 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Some homozygous animals show defects in brain development by embryonic day 12, reduced neuronal apoptosis causing hyperplasias, and pre- and postnatal lethality. Other homozygous animals exhibit only hearing loss, inner ear defects and degeneration of spiral ganglion neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    127
  • GO References
    47
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2951
  • Tissues
    621
  • cDNA Data
    66
  • Literature Summary
    2296
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031628 Ensembl Gene Model | MGI Sequence Detail 22399 C57BL/6J ±  kb
    transcript ENSMUST00000211115 Ensembl | MGI Sequence Detail 2601 Not Applicable  
    polypeptide ENSMUSP00000147767 Ensembl | MGI Sequence Detail 277 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 84
      Genomic 5
      cDNA 68
      Primer pair 9
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-36315, MGI:2442726, MGI:3717434
    References
    more
    • Summaries
      All 2657
      Developmental Gene Expression 2296
      Diseases 1
      Gene Ontology 47
      Phenotypes 144
    • Earliest
      J:34911 Juan TS, et al., Molecular characterization of mouse and rat CPP32 beta gene encoding a cysteine protease resembling interleukin-1 beta converting enzyme and CED-3. Oncogene. 1996 Aug 15;13(4):749-55
    • Latest
      J:346124 Feng Z, et al., TANGO6 regulates cell proliferation via COPI vesicle-mediated RPB2 nuclear entry. Nat Commun. 2024 Mar 15;15(1):2371
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory