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Casp3 Gene Detail
Summary
  • Symbol
    Casp3
  • Name
    caspase 3
  • Synonyms
    A830040C14Rik, AC-3, Apopain, Caspase-3, CC3, CPP32, mldy, Yama
  • Feature Type
    protein coding gene
  • IDs
    MGI:107739
    NCBI Gene: 12367
  • Gene Overview
    MyGene.info: CASP3
Location & Maps
more
  • Sequence Map
    Chr8:46617449-46638706 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21258 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CASP3, caspase 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CASP3, caspase 3
    Orthology source: HomoloGene
  • Synonyms
    CPP32, CPP32B, SCA-1
  • Links
    NCBI Gene ID: 836
    neXtProt AC: NX_P42574

  • Chr Location
    4q34; chr4:184627696-184649475 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Casp3 mouse models

Human Disease Mouse Models
       Diabetes Mellitus, Insulin-Dependent; IDDM   OMIM: 222100
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    81 phenotypes from 7 alleles in 10 genetic backgrounds
    29 phenotypes from multigenic genotypes
    1 images
    100 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (ENU)
    3
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Targeted
    7
  • Transgenic
    3
  • Genomic Mutations
    1 involving Casp3
  • Incidental Mutations
Some homozygous animals show defects in brain development by embryonic day 12, reduced neuronal apoptosis causing hyperplasias, and pre- and postnatal lethality. Other homozygous animals exhibit only hearing loss, inner ear defects and degeneration of spiral ganglion neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031628 Ensembl Gene Model | MGI Sequence Detail 21258 C57BL/6J ±  kb
transcript ENSMUST00000093517 Ensembl | MGI Sequence Detail 1455 Not Applicable  
polypeptide ENSMUSP00000091238 Ensembl | MGI Sequence Detail 277 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    269 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 79
    Genomic 5
    cDNA 64
    Primer pair 8
    Other 2

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-36315, MGI:2442726, MGI:3717434
References
more
  • Summaries
    All 1372
    Developmental Gene Expression 1153
    Diseases 1
    Gene Ontology 41
    Phenotypes 100
  • Earliest
    J:34911 Juan TS, et al., Molecular characterization of mouse and rat CPP32 beta gene encoding a cysteine protease resembling interleukin-1 beta converting enzyme and CED-3. Oncogene. 1996 Aug 15;13(4):749-55
  • Latest
    J:230878 Pilaz LJ, et al., Prolonged Mitosis of Neural Progenitors Alters Cell Fate in the Developing Brain. Neuron. 2016 Jan 6;89(1):83-99

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory