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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Casp3
caspase 3
MGI:107739
27 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Casp3tm1Flv/Casp3tm1Flv
Casp6tm1Flv/Casp6tm1Flv
involves: 129S1/Sv * C57BL/6J 		anophthalmia J:101037
anterior polar cataract J:101037
decreased body size J:101037
microphthalmia J:101037
normal vision/eye phenotype J:101037
Casp3tm1Flv/Casp3tm1Flv
Casp7tm1Flv/Casp7+
B6.129S-Casp3tm1Flv Casp7tm1Flv 		decreased fibroblast apoptosis J:105496
decreased sensitivity to induced cell death J:105496
decreased thymocyte apoptosis J:105496
Casp3tm1Flv/Casp3tm1Flv
Casp7tm1Flv/Casp7tm1Flv
B6.129S-Casp3tm1Flv Casp7tm1Flv 		abnormal heart ventricle morphology J:105496
decreased fibroblast apoptosis J:105496
decreased sensitivity to induced cell death J:105496
decreased thymocyte apoptosis J:105496
dilated heart atrium J:105496
exencephaly J:105496
neonatal lethality, incomplete penetrance J:105496
postnatal lethality, complete penetrance J:105496
Casp3tm1Flv/Casp3tm1Flv
Pde6brd1/Pde6brd1
involves: 129S1/Sv * C3H/FeJ * C57BL/6J 		abnormal apoptosis J:88367
abnormal eye development J:88367
decreased retina rod cell number J:88367
thick retina outer nuclear layer J:88367
Casp3tm1Flv/Casp3tm1Flv
Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli/0
involves: 129S1/Sv * C57BL/6 * CBA 		abnormal lung volume J:100854
emphysema J:100854
increased apoptosis J:100854
increased lung compliance J:100854
increased lymphocyte cell number J:100854
increased macrophage cell number J:100854
increased neutrophil cell number J:100854
Casp3tm1Mak/Casp3tm1Mak
Tg(TcrLCMV)327Sdz/0
B6.Cg-Casp3tm1Mak Tg(TcrLCMV)327Sdz 		abnormal CD8-positive, alpha beta T cell morphology J:97650
decreased cell proliferation J:97650
decreased physiological sensitivity to xenobiotic J:97650
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory