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Dnah5 Gene Detail
Summary
  • Symbol
    Dnah5
  • Name
    dynein, axonemal, heavy chain 5
  • Synonyms
    b2b1134Clo, b2b1154Clo, b2b1537Clo, b2b1565Clo, b2b3491Clo, Dnahc5, Mdnah5
  • Feature Type
    protein coding gene
  • IDs
    MGI:107718
    NCBI Gene: 110082
  • Gene Overview
    MyGene.info: DNAH5
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:28203752-28472052 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 10.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2096 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107718
protein coding gene Chr15:28154854-28472052 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021760
protein coding gene Chr15:26297577-26573891 (+)
A/J MGP_AJ_G0021720
protein coding gene Chr15:25300296-25558775 (+)
AKR/J MGP_AKRJ_G0021698
protein coding gene Chr15:25887840-26156151 (+)
BALB/cJ MGP_BALBcJ_G0021727
protein coding gene Chr15:25270219-25531899 (+)
C3H/HeJ MGP_C3HHeJ_G0021502
protein coding gene Chr15:25935953-26207791 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022166
protein coding gene Chr15:27348199-27633698 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019705
protein coding gene Chr15:23544301-23841492 (+)
CAST/EiJ MGP_CASTEiJ_G0021018
protein coding gene Chr15:26290749-26642235 (+)
CBA/J MGP_CBAJ_G0021471
protein coding gene Chr15:28161979-28442373 (+)
DBA/2J MGP_DBA2J_G0021595
protein coding gene Chr15:25046460-25301307 (+)
FVB/NJ MGP_FVBNJ_G0021573
protein coding gene Chr15:24636939-24896016 (+)
LP/J MGP_LPJ_G0021664
protein coding gene Chr15:26175924-26450858 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021598
protein coding gene Chr15:30893666-31181528 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022189
protein coding gene Chr15:26111240-26380967 (+)
PWK/PhJ MGP_PWKPhJ_G0020762
protein coding gene Chr15:25191836-25498054 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020600
protein coding gene Chr15:25868921-26193082 (+)
WSB/EiJ MGP_WSBEiJ_G0021074
protein coding gene Chr15:26020455-26354113 (+)



Homology
more
  • Human Ortholog
    DNAH5, dynein axonemal heavy chain 5
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DNAH5, dynein axonemal heavy chain 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CILD3, DNAHC5, HL1, KTGNR, PCD
  • Links
    NCBI Gene ID: 1767
    neXtProt AC: NX_Q8TE73
    UniProt: Q8TE73

  • Chr Location
    5p15.2; chr5:13690328-14011829 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    7 with Dnah5 mouse models; 1 with human DNAH5 associations

Human Disease Mouse Models
      
IDs
View 13 models
      
IDs
View 12 models
IDs
View 1 model
IDs
View 1 model
IDs
View 1 model
IDs
View 1 model
IDs
View 9 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    15 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    76 phenotypes from 16 alleles in 16 genetic backgrounds
    136 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene display postnatal lethality, hydrocephalus, respiratory infections, situs inversus and ciliary immotility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022262 Ensembl Gene Model | MGI Sequence Detail 268301 C57BL/6J ±  kb
    transcript ENSMUST00000067048 Ensembl | MGI Sequence Detail 15637 Not Applicable  
    polypeptide ENSMUSP00000069751 Ensembl | MGI Sequence Detail 4621 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36294, MGI:2146141, MGI:5311155, MGI:5311349, MGI:5311351, MGI:5430340, MGI:5433314, MGI:5648246
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 8
      Diseases 3
      Gene Ontology 10
      Phenotypes 23
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:260436 Desai PB, et al., Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development. Mech Dev. 2018 Jun;151:10-17

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory