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Myh9 Gene Detail
Summary
  • Symbol
    Myh9
  • Name
    myosin, heavy polypeptide 9, non-muscle
  • Synonyms
    D0Jmb2, E030044M24Rik, Fltn, Myhn1, Myhn-1, myosin IIA, NMHC II-A
  • Feature Type
    protein coding gene
  • IDs
    MGI:107717
    NCBI Gene: 17886
  • Gene Overview
    MyGene.info: MYH9
Location & Maps
more
  • Sequence Map
    Chr15:77760587-77842175 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      81589 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 36.81 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MYH9, myosin, heavy chain 9, non-muscle
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MYH9, myosin, heavy chain 9, non-muscle
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BDPLT6, DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHCA, NMMHC-IIA
  • Links
    NCBI Gene ID: 4627
    neXtProt AC: NX_P35579

  • Chr Location
    22q13.1; chr22:36281277-36388067 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    4 with Myh9 mouse models; 6 with human MYH9 associations

Human Disease Mouse Models
       Epstein Syndrome; EPSTNS   OMIM: 153650 View 4 models
Fechtner Syndrome; FTNS   OMIM: 153640 View 4 models
May-Hegglin Anomaly; MHA   OMIM: 155100 View 4 models
Sebastian Syndrome; SBS   OMIM: 605249 View 4 models
       Deafness, Autosomal Dominant 17; DFNA17   OMIM: 603622
Macrothrombocytopenia and Progressive Sensorineural Deafness   OMIM: 600208
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    71 phenotypes from 16 alleles in 17 genetic backgrounds
    3 images
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    368
  • Chemically induced (other)
    2
  • Gene trapped
    347
  • Radiation induced
    2
  • Targeted
    17
  • Genomic Mutations
    4 involving Myh9
  • Incidental Mutations
Homozygous null mice display embryonic lethality. Heterozygous null mice display hearing loss with incomplete penetrance. Mice homozygous or heterozygous for one of several knock-in alleles exhibit macrothrombocytopenia, nephritis, cataracts and deafness.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016428 VEGA Gene Model | MGI Sequence Detail 81589 C57BL/6J ±  kb
transcript OTTMUST00000039563 VEGA | MGI Sequence Detail 7433 Not Applicable  
polypeptide OTTMUSP00000017674 VEGA | MGI Sequence Detail 1960 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    391 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 178
    cDNA 178

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-12745, MGD-MRK-12749, MGD-MRK-36293, MGI:1206575, MGI:1344335, MGI:2146296, MGI:2443228, MGI:97257
References
more
  • Summaries
    All 118
    Developmental Gene Expression 25
    Diseases 2
    Gene Ontology 21
    Phenotypes 58
  • Earliest
    J:15308 Shohet RV, et al., Cloning of the cDNA encoding the myosin heavy chain of a vertebrate cellular myosin. Proc Natl Acad Sci U S A. 1989 Oct;86(20):7726-30
  • Latest
    J:224944 Ozkan ED, et al., Input-specific regulation of hippocampal circuit maturation by non-muscle myosin IIB. J Neurochem. 2015 Aug;134(3):429-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory