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Myh9
Gene Detail
Symbol

Name
ID
Myh9
myosin, heavy polypeptide 9, non-muscle
MGI:107717
Synonyms
D0Jmb2, E030044M24Rik, Fltn, Myhn1, Myhn-1, myosin IIA, NMHC II-A
Feature Type
protein coding gene
Genetic Map
Chromosome 15
36.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:77760587-77842175 bp, - strand
From VEGA annotation of GRCm38

  81589 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:129835  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MYH9
Gene Tree: Myh9

Human
homologs
MYH9, myosin, heavy chain 9, non-muscle
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4627
neXtProt AC: NX_P35579

Human Synonyms: BDPLT6, DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHCA, NMMHC-IIA

Human Chr (Location): 22q13.1; chr22:36281277-36388067 (-)  GRCh38.p2

Disease Associations: (6) Diseases Associated with Human MYH9

Mutations,
alleles, and
phenotypes
All mutations/alleles(365) : Gene trapped(347) Radiation induced(1) Targeted(17)
Genomic Mutations involving Myh9 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display embryonic lethality. Heterozygous null mice display hearing loss with incomplete penetrance. Mice homozygous or heterozygous for one of several knock-in alleles exhibit macrothrombocytopenia, nephritis, cataracts and deafness.
 
Human Diseases Modeled in Mice Using Myh9 (4)    Mutations Annotated to Human Diseases (2)    Phenotype Images(2)
Interactions
Myh9 interacts with 243 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (81 annotations)
Process actin cytoskeleton reorganization, actin filament-based movement, ...
Component actin cytoskeleton, actomyosin, ...
Function actin binding, actin-dependent ATPase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (118)    Tissues (36)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 34
RNA in situ 84
cDNA source data(178)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase myh9 ; ZFIN myh9b    NEW 
Molecular
reagents
All nucleic(178) cDNA(178)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000016428 (Evidence)
Ensembl Gene Model ENSMUSG00000022443 (Evidence)
Entrez Gene 17886 (Evidence)
UniGene 29677
DFCI TC1718499, TC1589172, TC1588495, TC1573750
DoTS DT.110802887, DT.101712852, DT.101389029, DT.94193821, DT.91330528, DT.534505, DT.97413493, DT.99842240, DT.97413496
NIA Mouse Gene Index U036371
Consensus CDS Project CCDS27605.1
International Mouse Phenotyping Consortium Status Myh9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016428 VEGA Gene Model | MGI Sequence Detail 81589 C57BL/6J ±  kb
transcript OTTMUST00000039563 VEGA | MGI Sequence Detail 7433 Not Applicable 
polypeptide OTTMUSP00000017674 VEGA | MGI Sequence Detail 1960 Not Applicable 

For the selected sequences
All sequences(89) RefSeq(2) UniProt(11)
Polymorphisms
RFLP(1) : SNPs within 2kb(391 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001609 Myosin head, motor domain
InterPro IPR027401 Myosin-like IQ motif-containing domain
InterPro IPR004009 Myosin, N-terminal, SH3-like
InterPro IPR002928 Myosin tail
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010833 myosin-9
References
(Earliest) J:15308 Shohet RV, et al., Cloning of the cDNA encoding the myosin heavy chain of a vertebrate cellular myosin. Proc Natl Acad Sci U S A. 1989 Oct;86(20):7726-30
(Latest) J:220018 Solanes P, et al., Space exploration by dendritic cells requires maintenance of myosin II activity by IP3 receptor 1. EMBO J. 2015 Mar 12;34(6):798-810
All references(117)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-12745, MGD-MRK-12749, MGD-MRK-36293, MGI:1206575, MGI:1344335, MGI:2146296, MGI:2443228, MGI:97257

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory