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Myh9
Gene Detail
 Symbol
Name
ID
Myh9
myosin, heavy polypeptide 9, non-muscle
MGI:107717
Synonyms D0Jmb2, E030044M24Rik, Fltn, Myhn1, Myhn-1, myosin IIA, NMHC II-A
Feature Type protein coding gene
Genetic Map
Chromosome 15
36.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:77760587-77842175 bp, - strand
From VEGA annotation of GRCm38

  81589 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:129835  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Myh9

Human
homologs
Human Homolog MYH9, myosin, heavy chain 9, non-muscle
NCBI Gene ID 4627
neXtProt AC  NX_P35579
Human Synonyms  BDPLT6, DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHCA, NMMHC-IIA
Human Chr (Location)  22q13.1; chr22:36281277-36388018 (-)  GRCh38
Disease Associations  (6) Diseases Associated with Human MYH9
Mutations,
alleles, and
phenotypes
All mutations/alleles(365) : Gene trapped(347) Radiation induced(1) Targeted(17)
Genomic Mutations involving Myh9 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality. Heterozygous null mice display hearing loss with incomplete penetrance. Mice homozygous or heterozygous for one of several knock-in alleles exhibit macrothrombocytopenia, nephritis, cataracts and deafness.
 
Human Diseases Modeled Using Mouse Myh9 (4)    Alleles Annotated to Human Diseases(2)   
Interactions
Myh9 interacts with 243 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (71 annotations)
Process actin cytoskeleton reorganization, actin filament-based movement, ...
Component actin cytoskeleton, actomyosin, ...
Function actin binding, actin-dependent ATPase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (118)    Tissues (36)    Images (21)
Theiler Stages: 12, 13, 14, 15, 19, 23
Assay TypeResults
Immunohistochemistry 34
RNA in situ 84
cDNA source data(178)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(178) cDNA(178)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000016428 (Evidence)
Ensembl Gene ModelENSMUSG00000022443 (Evidence)
Entrez Gene17886 (Evidence)
UniGene29677
DFCITC1573750, TC1588495, TC1589172, TC1718499
DoTSDT.101389029, DT.101712852, DT.110802887, DT.534505, DT.91330528, DT.94193821, DT.97413493, DT.97413496, DT.99842240
NIA Mouse Gene IndexU036371
Consensus CDS ProjectCCDS27605.1
International Mouse Knockout Project StatusMyh9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016428 VEGA Gene Model | MGI Sequence Detail 81589 C57BL/6J ±  kb
transcript OTTMUST00000039563 VEGA | MGI Sequence Detail 7433 Not Applicable 
polypeptide OTTMUSP00000017674 VEGA | MGI Sequence Detail 1960 Not Applicable 

For the selected sequences
All sequences(89) RefSeq(2) UniProt(11)
Polymorphisms RFLP(1) : SNPs within 2kb(391 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001609 Myosin head, motor domain
InterPro IPR027401 Myosin-like IQ motif-containing domain
InterPro IPR004009 Myosin, N-terminal, SH3-like
InterPro IPR002928 Myosin tail
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010833 myosin-9
References (Earliest) J:15308 Shohet RV, et al., Cloning of the cDNA encoding the myosin heavy chain of a vertebrate cellular myosin. Proc Natl Acad Sci U S A. 1989 Oct;86(20):7726-30
(Latest) J:208720 Pertuy F, et al., Myosin IIA is critical for organelle distribution and F-actin organization in megakaryocytes and platelets. Blood. 2014 Feb 20;123(8):1261-9
All references(110)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-12745, MGD-MRK-12749, MGD-MRK-36293, MGI:1206575, MGI:1344335, MGI:2146296, MGI:2443228, MGI:97257

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory