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Myh9 Gene Detail
Summary
  • Symbol
    Myh9
  • Name
    myosin, heavy polypeptide 9, non-muscle
  • Synonyms
    D0Jmb2, E030044M24Rik, Fltn, Myhn1, Myhn-1, myosin IIA, NMHC II-A
  • Feature Type
    protein coding gene
  • IDs
    MGI:107717
    NCBI Gene: 17886
  • Gene Overview
    MyGene.info: MYH9
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:77760587-77842175 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      81589 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 36.81 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MYH9, myosin heavy chain 9
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MYH9, myosin heavy chain 9
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BDPLT6, DFNA17, EPSTS, FTNS, MATINS, MHA, NMHC-II-A, NMMHCA, NMMHC-IIA
  • Links
    NCBI Gene ID: 4627
    neXtProt AC: NX_P35579
    UniProt: P35579

  • Chr Location
    22q12.3; chr22:36281277-36388067 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Myh9 mouse models; 2 with human MYH9 associations

Human Disease Mouse Models
      
IDs
View 4 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    69 phenotypes from 15 alleles in 16 genetic backgrounds
    3 images
    72 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality. Heterozygous null mice display hearing loss with incomplete penetrance. Mice homozygous or heterozygous for one of several knock-in alleles exhibit macrothrombocytopenia, nephritis, cataracts and deafness.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016428 VEGA Gene Model | MGI Sequence Detail 81589 C57BL/6J ±  kb
    transcript OTTMUST00000039563 VEGA | MGI Sequence Detail 7433 Not Applicable  
    polypeptide OTTMUSP00000017674 VEGA | MGI Sequence Detail 1960 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      391 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 179
      cDNA 179

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12745, MGD-MRK-12749, MGD-MRK-36293, MGI:1206575, MGI:1344335, MGI:2146296, MGI:2443228, MGI:97257
    References
    more
    • Summaries
      All 167
      Developmental Gene Expression 35
      Diseases 2
      Gene Ontology 21
      Phenotypes 72
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:265242 Zehrer A, et al., A Fundamental Role of Myh9 for Neutrophil Migration in Innate Immunity. J Immunol. 2018 Sep 15;201(6):1748-1764

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory