Myh9
Gene Detail

Symbol Name ID

Myh9 myosin, heavy polypeptide 9, non-muscle MGI:107717

Synonyms

D0Jmb2, E030044M24Rik, Fltn, Myhn1, Myhn-1, myosin IIA, NMHC II-A

Feature Type

protein coding gene

Genetic Map

Chromosome 15

36.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr15:77760587-77842175 bp, - strand From VEGA annotation of GRCm38   81589 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:129835  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Myh9

Human homologs

Human Homolog		MYH9, myosin, heavy chain 9, non-muscle
NCBI Gene ID		4627
neXtProt AC		NX_P35579
Human Synonyms		BDPLT6, DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHCA, NMMHC-IIA
Human Chr (Location)		22q13.1; chr22:36677323-36784063 (-)  GRCh37.p10
Disease Associations		(6) Diseases Associated with Human MYH9

Alleles and phenotypes

All alleles(357) : Targeted(10) Gene trapped(347)
 

Homozygous null mice display embryonic lethality. Heterozygous null mice display hearing loss with incomplete penetrance but no kidney or hematopoietic defects. Mice homozygous for a conditional allele activated in T cells exhibit impaired T cell migration and adhesion.

 

Gene Ontology (GO) classifications

All GO classifications: (76 annotations)

Process	actin cytoskeleton reorganization, actin filament-based movement, ...
Component	actin cytoskeleton, actomyosin contractile ring, ...
Function	actin binding, actin-dependent ATPase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (20 records)
Data Summary: Results (118)    Tissues (36)    Images (21)
Theiler Stages: 12, 13, 14, 15, 19, 23

Assay Type	Results
Immunohistochemistry	34
RNA in situ	84

cDNA source data(172)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(172) cDNA(172)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000016428 (Evidence)
Ensembl Gene Model	ENSMUSG00000022443 (Evidence)
Entrez Gene	17886 (Evidence)
UniGene	29677
DFCI	TC1573750, TC1588495, TC1589172, TC1718499
DoTS	DT.101389029, DT.101712852, DT.534505, DT.91330528, DT.94193821, DT.97413493, DT.97413496, DT.99842240
NIA Mouse Gene Index	U036371
Consensus CDS Project	CCDS27605.1
International Mouse Knockout Project Status	Myh9

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016428	VEGA Gene Model | MGI Sequence Detail	81589	C57BL/6J
transcript	OTTMUST00000039563	VEGA | MGI Sequence Detail	7433	Not Applicable
polypeptide	OTTMUSP00000017674	VEGA | MGI Sequence Detail	1960	Not Applicable

All sequences(86) RefSeq(2) UniProt(11)

Polymorphisms

RFLP(1) : SNPs(359 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000048	IQ motif, EF-hand binding site
InterPro	IPR001609	Myosin head, motor domain
InterPro	IPR027401	Myosin-like IQ motif-containing domain
InterPro	IPR004009	Myosin, N-terminal, SH3-like
InterPro	IPR002928	Myosin tail
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Protein Ontology	PR:000010833	myosin-9

References

(Earliest) J:15308 Shohet RV, et al., Cloning of the cDNA encoding the myosin heavy chain of a vertebrate cellular myosin. Proc Natl Acad Sci U S A. 1989 Oct;86(20):7726-30
(Latest) J:192804 Yates LL, et al., Scribble is required for normal epithelial cell-cell contacts and lumen morphogenesis in the mammalian lung. Dev Biol. 2013 Jan 15;373(2):267-80
All references(101)

Other accession IDs

MGD-MRK-12745, MGD-MRK-12749, MGD-MRK-36293, MGI:1206575, MGI:1344335, MGI:2146296, MGI:2443228, MGI:97257