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Dnah8 Gene Detail
Summary
  • Symbol
    Dnah8
  • Name
    dynein, axonemal, heavy chain 8
  • Synonyms
    Dnahc8, Hst6.7b, P1-Loop
  • Feature Type
    protein coding gene
  • IDs
    MGI:107714
    NCBI Gene: 13417
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:30845909-31094736 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 15.71 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1581 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107714
protein coding gene Chr17:30843328-31096339 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023477
protein coding gene Chr17:30265412-30574924 (+)
A/J MGP_AJ_G0023435
protein coding gene Chr17:29257810-29563715 (+)
AKR/J MGP_AKRJ_G0023400
protein coding gene Chr17:29492814-29829554 (+)
BALB/cJ MGP_BALBcJ_G0023440
protein coding gene Chr17:29444636-29702581 (+)
C3H/HeJ MGP_C3HHeJ_G0023201
protein coding gene Chr17:29903450-30206650 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023882
protein coding gene Chr17:31385879-31659655 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021356
protein coding gene Chr17:26497262-26745561 (+)
CAST/EiJ MGP_CASTEiJ_G0022702
protein coding gene Chr17:29886778-30227392 (+)
CBA/J MGP_CBAJ_G0023176
protein coding gene Chr17:32677807-33044879 (+)
DBA/2J MGP_DBA2J_G0023306
protein coding gene Chr17:28718057-29009945 (+)
FVB/NJ MGP_FVBNJ_G0023276
protein coding gene Chr17:28543659-28799940 (+)
LP/J MGP_LPJ_G0023384
protein coding gene Chr17:30509357-30811430 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023294
protein coding gene Chr17:31853373-32131768 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023924
protein coding gene Chr17:29929972-30201669 (+)
PWK/PhJ MGP_PWKPhJ_G0022452
protein coding gene Chr17:27573744-27828684 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022270
protein coding gene Chr17:27934256-28197179 (+)
WSB/EiJ MGP_WSBEiJ_G0022764
protein coding gene Chr17:29903023-30170330 (+)



Homology
more
  • Human Ortholog
    DNAH8, dynein axonemal heavy chain 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNAH8, dynein axonemal heavy chain 8
  • Synonyms
    ATPase, hdhc9, SPGF46
  • Links
    NCBI Gene ID: 1769
    neXtProt AC: NX_Q96JB1
    UniProt: Q96JB1

  • Chr Location
    6p21.2; chr6:38715329-39030798 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Dnah8 mouse models; 1 with human DNAH8 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit male infertility due to sperm immobility and malformed and/or absent flagella.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13417 NCBI Gene Model | MGI Sequence Detail 248828 C57BL/6J ±  kb
    transcript NM_013811 RefSeq | MGI Sequence Detail 14583 Not Specified  
    polypeptide Q91XQ0 UniProt | EBI | MGI Sequence Detail 4731 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000029434 dynein heavy chain 8, axonemal
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR026983 Dynein heavy chain
      IPR041589 Dynein heavy chain 3, AAA+ lid domain
      IPR043157 Dynein heavy chain, AAA1 domain, small subdomain
      IPR041466 Dynein heavy chain, AAA 5 extension domain
      IPR041658 Dynein heavy chain AAA lid domain
      IPR042219 Dynein heavy chain AAA lid domain superfamily
      IPR024317 Dynein heavy chain, AAA module D4
      IPR035706 Dynein heavy chain, ATP-binding dynein motor region
      IPR024743 Dynein heavy chain, coiled coil stalk
      IPR041228 Dynein heavy chain, C-terminal domain
      IPR043160 Dynein heavy chain, C-terminal domain, barrel region
      IPR042222 Dynein heavy chain, domain 2, N-terminal
      IPR035699 Dynein heavy chain, hydrolytic ATP-binding dynein motor region
      IPR013602 Dynein heavy chain, linker
      IPR042228 Dynein heavy chain, linker, subdomain 3
      IPR004273 Dynein heavy chain region D6 P-loop domain
      IPR013594 Dynein heavy chain, tail
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36290
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 6
      Phenotypes 6
    • Earliest
      J:34934 Vaughan KT, et al., Multiple mouse chromosomal loci for dynein-based motility. Genomics. 1996 Aug 15;36(1):29-38
    • Latest
      J:297137 Liu C, et al., Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility. Am J Hum Genet. 2020 Aug 6;107(2):330-341

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    07/20/2021
    MGI 6.17
    The Jackson Laboratory