Plxna2 MGI Mouse Gene Detail - MGI:107684

Symbol

Plxna2
Name

plexin A2
Synonyms

2810428A13Rik, mKIAA0463, OCT, PlexA2, Plxn2

Feature Type

protein coding gene
IDs

MGI:107684
NCBI Gene: 18845
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr1:194302020-194499177 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 98.27 cM, cytoband H6
Mapping Data

3 experiments

SNPs within 2kb

829 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107684	protein coding gene	Chr1:194300526-194499177 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016965	protein coding gene	Chr1:201772937-201979146 (+)
A/J	MGP_AJ_G0016944	protein coding gene	Chr1:193492479-193691376 (+)
AKR/J	MGP_AKRJ_G0016909	protein coding gene	Chr1:199221155-199425804 (+)
BALB/cJ	MGP_BALBcJ_G0016902	protein coding gene	Chr1:194180212-194380984 (+)
C3H/HeJ	MGP_C3HHeJ_G0016726	protein coding gene	Chr1:200112412-200313869 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017365	protein coding gene	Chr1:208151787-208359849 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015072	protein coding gene	Chr1:184618028-184814053 (+)
CAST/EiJ	MGP_CASTEiJ_G0016309	protein coding gene	Chr1:199677433-199879680 (+)
CBA/J	MGP_CBAJ_G0016700	protein coding gene	Chr1:215835685-216049752 (+)
DBA/2J	MGP_DBA2J_G0016806	protein coding gene	Chr1:192207919-192404684 (+)
FVB/NJ	MGP_FVBNJ_G0016802	protein coding gene	Chr1:190307165-190504805 (+)
LP/J	MGP_LPJ_G0016881	protein coding gene	Chr1:202929523-203136604 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016834	protein coding gene	Chr1:222479053-222687854 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017402	protein coding gene	Chr1:199071251-199280952 (+)
PWK/PhJ	MGP_PWKPhJ_G0016096	protein coding gene	Chr1:191524600-191724281 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015872	protein coding gene	Chr1:198090083-198299669 (+)
WSB/EiJ	MGP_WSBEiJ_G0016371	protein coding gene	Chr1:199354095-199556396 (+)

Human Ortholog

PLXNA2, plexin A2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLXNA2, plexin A2
Synonyms

OCT, PLXN2
Links

HGNC:9100

NCBI Gene ID: 5362

neXtProt AC: NX_O75051

UniProt: O75051
Chr Location

1q32.2; chr1:208022242-208244384 (-) GRCh38

MGI Vertebrate Homology

Plxna2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PLXNA2
Gene Tree

Plxna2

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Phenotype Summary

13 phenotypes from 3 alleles in 6 genetic backgrounds
6 phenotypes from multigenic genotypes
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (ENU)

1
Endonuclease-mediated

3
Gene trapped

1
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

127 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show abnormal granule cell migration in the adult cerebellum and aberrant projection of mossy fibers in hippocampal slices. Mice homozygous for an ENU-induced allele are smaller and show granule cell migration defects and mild ataxia with incomplete penetrance.

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All GO Annotations

28
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1057
Tissues

218
cDNA Data

25
Literature Summary

95

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PLXNA2

Xenbase plxna2

ZFIN plxna2

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All Sequences

57
RefSeq

7
UniProt

3
CCDS

CCDS35827.1

Ensembl

ENSMUSG00000026640 (Evidence)
NCBI Gene

18845

			Length	Strain/Species	Flank
genomic	18845	NCBI Gene Model \| MGI Sequence Detail	197158	C57BL/6J	± kb
transcript	NM_008882	RefSeq \| MGI Sequence Detail	11049	C57BL/6
polypeptide	P70207	UniProt \| EBI \| MGI Sequence Detail	1894	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012893 plexin-A2

(term hierarchy)
PDB

3AL8, 3AL9, 3OKT, 3OKY, 4GZA, 5L5G, 5L74
InterPro Domains

IPR014756 Immunoglobulin E-set

IPR013783 Immunoglobulin-like fold

IPR002909 IPT domain

IPR042826 Plexin-A2, sema domain

IPR013548 Plexin, cytoplasmic RasGAP domain

IPR046800 Plexin, cytoplasmic RhoGTPase-binding domain

IPR031148 Plexin family

IPR002165 Plexin repeat

IPR041019 Plexin, TIG domain 1

IPR041362 Plexin, TIG domain 2

IPR016201 PSI domain

IPR008936 Rho GTPase activation protein

IPR001627 Sema domain

IPR036352 Sema domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

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All nucleic 32

cDNA 26

Primer pair 1

Other 5

Microarray probesets 8

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MGD-MRK-36259, MGI:1919991, MGI:2138117, MGI:2138589

Summaries

All 150

Developmental Gene Expression 95

Gene Ontology 8

Phenotypes 29
Earliest

J:35259 Kameyama T, et al., Identification of plexin family molecules in mice. Biochem Biophys Res Commun. 1996 Sep 13;226(2):396-402
Latest

J:346588 Nagy GN, et al., Structure and function of Semaphorin-5A glycosaminoglycan interactions. Nat Commun. 2024 Mar 28;15(1):2723

TSS for Plxna2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10836	Chr1:194302123-194302141 (+)	112 bp
Tssr10837	Chr1:194302158-194302180 (+)	149 bp
Tssr10838	Chr1:194302195-194302222 (+)	189 bp
Tssr10839	Chr1:194302225-194302240 (+)	213 bp
Tssr10840	Chr1:194302409-194302418 (+)	394 bp
Tssr10841	Chr1:194309215-194309220 (+)	7,198 bp
Tssr381	Chr1:194426429-194426432 (+)	124,411 bp
Tssr10842	Chr1:194431775-194431788 (+)	129,762 bp
Tssr10843	Chr1:194431790-194431807 (+)	129,779 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23