Plxna2 MGI Mouse Gene Detail - MGI:107684

Symbol

Plxna2
Name

plexin A2
Synonyms

2810428A13Rik, mKIAA0463, OCT, PlexA2, Plxn2

Feature Type

protein coding gene
IDs

MGI:107684
NCBI Gene: 18845
Gene Overview

MyGene.info: PLXNA2
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:194619829-194816869 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 98.27 cM, cytoband H6
Mapping Data

3 experiments

SNPs within 2kb

828 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107684	protein coding gene	Chr1:194618218-194816869 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016965	protein coding gene	Chr1:201772937-201979146 (+)
A/J	MGP_AJ_G0016944	protein coding gene	Chr1:193492479-193691376 (+)
AKR/J	MGP_AKRJ_G0016909	protein coding gene	Chr1:199221155-199425804 (+)
BALB/cJ	MGP_BALBcJ_G0016902	protein coding gene	Chr1:194180212-194380984 (+)
C3H/HeJ	MGP_C3HHeJ_G0016726	protein coding gene	Chr1:200112412-200313869 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017365	protein coding gene	Chr1:208151787-208359849 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015072	protein coding gene	Chr1:184618028-184814053 (+)
CAST/EiJ	MGP_CASTEiJ_G0016309	protein coding gene	Chr1:199677433-199879680 (+)
CBA/J	MGP_CBAJ_G0016700	protein coding gene	Chr1:215835685-216049752 (+)
DBA/2J	MGP_DBA2J_G0016806	protein coding gene	Chr1:192207919-192404684 (+)
FVB/NJ	MGP_FVBNJ_G0016802	protein coding gene	Chr1:190307165-190504805 (+)
LP/J	MGP_LPJ_G0016881	protein coding gene	Chr1:202929523-203136604 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016834	protein coding gene	Chr1:222479053-222687854 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017402	protein coding gene	Chr1:199071251-199280952 (+)
PWK/PhJ	MGP_PWKPhJ_G0016096	protein coding gene	Chr1:191524600-191724281 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015872	protein coding gene	Chr1:198090083-198299669 (+)
WSB/EiJ	MGP_WSBEiJ_G0016371	protein coding gene	Chr1:199354095-199556396 (+)

Human Ortholog

PLXNA2, plexin A2

Vertebrate Orthologs

10

Human Ortholog

PLXNA2, plexin A2
Orthology source: HomoloGene, HGNC
Synonyms

OCT, PLXN2
Links

HGNC:9100

NCBI Gene ID: 5362

neXtProt AC: NX_O75051

UniProt: O75051
Chr Location

1q32.2; chr1:208022242-208244384 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 56427
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: PLXNA2
Gene Tree

Plxna2

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Phenotype Summary

12 phenotypes from 3 alleles in 5 genetic backgrounds
6 phenotypes from multigenic genotypes
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (ENU)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show abnormal granule cell migration in the adult cerebellum and aberrant projection of mossy fibers in hippocampal slices. Mice homozygous for an ENU-induced allele are smaller and show granule cell migration defects and mild ataxia with incomplete penetrance.

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All GO Annotations

26
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

231
Tissues

135
cDNA Data

23
Literature Summary

81

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PLXNA2

Xenbase plxna2

ZFIN plxna2

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Plxna2 interacts with 466 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

55
RefSeq

5
UniProt

3
CCDS

CCDS35827.1

Ensembl

ENSMUSG00000026640 (Evidence)
NCBI Gene

18845

			Length	Strain/Species	Flank
genomic	18845	NCBI Gene Model \| MGI Sequence Detail	197041	C57BL/6J	± kb
transcript	NM_008882	RefSeq \| MGI Sequence Detail	11049	C57BL/6
polypeptide	P70207	UniProt \| EBI \| MGI Sequence Detail	1894	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012893 plexin-A2

(term hierarchy)
PDB

3AL8, 3AL9, 3OKT, 3OKY, 4GZA, 5L5G, 5L74
InterPro Domains

IPR014756 Immunoglobulin E-set

IPR013783 Immunoglobulin-like fold

IPR002909 IPT domain

IPR013548 Plexin, cytoplasmic RasGAP domain

IPR031148 Plexin family

IPR002165 Plexin repeat

IPR041019 Plexin, TIG domain 1

IPR041362 Plexin, TIG domain 2

IPR016201 PSI domain

IPR008936 Rho GTPase activation protein

IPR001627 Sema domain

IPR036352 Sema domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

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All nucleic 27

cDNA 24

Primer pair 1

Other 2

Microarray probesets 8

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MGD-MRK-36259, MGI:1919991, MGI:2138117, MGI:2138589

Summaries

All 130

Developmental Gene Expression 81

Gene Ontology 8

Phenotypes 21
Earliest

J:35259 Kameyama T, et al., Identification of plexin family molecules in mice. Biochem Biophys Res Commun. 1996 Sep 13;226(2):396-402
Latest

J:271262 Zhao XF, et al., PlexinA2 Forward Signaling through Rap1 GTPases Regulates Dentate Gyrus Development and Schizophrenia-like Behaviors. Cell Rep. 2018 Jan 9;22(2):456-470

TSS for Plxna2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10836	Chr1:194619815-194619833 (+)	-5 bp
Tssr10837	Chr1:194619850-194619872 (+)	32 bp
Tssr10838	Chr1:194619887-194619914 (+)	72 bp
Tssr10839	Chr1:194619917-194619932 (+)	96 bp
Tssr10840	Chr1:194620101-194620110 (+)	277 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/08/2019 MGI 6.14