Plxna2
Gene Detail

Symbol

Name
ID

Plxna2
plexin A2
MGI:107684

Synonyms

2810428A13Rik, mKIAA0463, OCT, PlexA2, Plxn2

Feature Type

protein coding gene

Genetic Map

Chromosome 1
98.27 cM, cytoband H6
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:194618218-194816869 bp, + strand From VEGA annotation of GRCm38   198652 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:56427  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Plxna2

Human
homologs

Human Homolog		PLXNA2, plexin A2
NCBI Gene ID		5362
neXtProt AC		NX_O75051
Human Synonyms		OCT, PLXN2
Human Chr (Location)		1q32.2; chr1:208022242-208244320 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(8) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele show abnormal granule cell migration in the adult cerebellum and aberrant projection of mossy fibers in hippocampal slices. Mice homozygous for an ENU-induced allele are smaller and show granule cell migration defects and mild ataxia with incomplete penetrance.

 

Interactions

Plxna2 interacts with 466 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (16 annotations)

Process	cell surface receptor signaling pathway, centrosome localization, ...
Component	integral component of membrane, integral component of plasma membrane, ...
Function	semaphorin receptor activity

External Resources: FuncBase

Expression

Literature Summary: (67 records)

Data Summary: Results (216)    Tissues (126)    Images (61)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	207
Northern blot	1
RT-PCR	8

cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(25) cDNA(23) Primer pair(1) Other(1)
Microarray probesets(8)

Other database
links

VEGA Gene Model	OTTMUSG00000017321 (Evidence)
Ensembl Gene Model	ENSMUSG00000026640 (Evidence)
Entrez Gene	18845 (Evidence)
DFCI	TC1583683, TC1579404, TC1619941, TC1626692
DoTS	DT.87059665, DT.522492, DT.40171084, DT.91410254
PDB	4GZA, 3OKY, 3OKT, 3AL8, 3AL9
Consensus CDS Project	CCDS35827.1
International Mouse Knockout Project Status	Plxna2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017321	VEGA Gene Model | MGI Sequence Detail	198652	C57BL/6J
transcript	OTTMUST00000042096	VEGA | MGI Sequence Detail	11040	Not Applicable
polypeptide	OTTMUSP00000018927	VEGA | MGI Sequence Detail	1894	Not Applicable

All sequences(53) RefSeq(5) UniProt(3)

Polymorphisms

SNPs within 2kb(838 from dbSNP Build 137)    SNPs within 2kb including multiple locations(840)

Protein-related
information

Resource	ID	Description
InterPro	IPR002909	Cell surface receptor IPT/TIG
InterPro	IPR014756	Immunoglobulin E-set
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR002165	Plexin
InterPro	IPR013548	Plexin, cytoplasmic RasGAP domain
InterPro	IPR016201	Plexin-like fold
InterPro	IPR008936	Rho GTPase activation protein
InterPro	IPR001627	Semaphorin/CD100 antigen
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000012893	plexin-A2

References

(Earliest) J:35259 Kameyama T, et al., Identification of plexin family molecules in mice. Biochem Biophys Res Commun. 1996 Sep 13;226(2):396-402
(Latest) J:214093 Cambier L, et al., Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3. Development. 2014 Aug;141(15):2959-71
All references(110)

Other
accession IDs

MGD-MRK-36259, MGI:1919991, MGI:2138117, MGI:2138589