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Plxna2
Gene Detail
Symbol

Name
ID
Plxna2
plexin A2
MGI:107684
Synonyms
2810428A13Rik, mKIAA0463, OCT, PlexA2, Plxn2
Feature Type
protein coding gene
Genetic Map
Chromosome 1
98.27 cM, cytoband H6
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:194618218-194816869 bp, + strand
From VEGA annotation of GRCm38

  198652 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56427  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PLXNA2
Gene Tree: Plxna2

Human
homologs
PLXNA2, plexin A2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5362
neXtProt AC: NX_O75051

Human Synonyms: OCT, PLXN2

Human Chr (Location): 1q32.2; chr1:208022242-208244384 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele show abnormal granule cell migration in the adult cerebellum and aberrant projection of mossy fibers in hippocampal slices. Mice homozygous for an ENU-induced allele are smaller and show granule cell migration defects and mild ataxia with incomplete penetrance.
 
Interactions
Plxna2 interacts with 466 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (68 records)
Data Summary: Results (220)    Tissues (128)    Images (63)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 211
Northern blot 1
RT-PCR 8
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PLXNA2 ; Xenbase plxna2    NEW 
Molecular
reagents
All nucleic(26) cDNA(23) Primer pair(1) Other(2)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000017321 (Evidence)
Ensembl Gene Model ENSMUSG00000026640 (Evidence)
Entrez Gene 18845 (Evidence)
DFCI TC1579404, TC1583683, TC1619941, TC1626692
DoTS DT.40171084, DT.522492, DT.87059665, DT.91410254
PDB 3AL8, 3AL9, 3OKT, 3OKY, 4GZA
Consensus CDS Project CCDS35827.1
International Mouse Phenotyping Consortium Status Plxna2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017321 VEGA Gene Model | MGI Sequence Detail 198652 C57BL/6J ±  kb
transcript OTTMUST00000042096 VEGA | MGI Sequence Detail 11040 Not Applicable 
polypeptide OTTMUSP00000018927 VEGA | MGI Sequence Detail 1894 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(5) UniProt(3)
Polymorphisms
SNPs within 2kb(838 from dbSNP Build 137)    SNPs within 2kb including multiple locations(840)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR002909 IPT domain
InterPro IPR013548 Plexin, cytoplasmic RasGAP domain
InterPro IPR031148 Plexin family
InterPro IPR016201 Plexin-like fold
InterPro IPR002165 Plexin repeat
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR001627 Sema domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000012893 plexin-A2
References
(Earliest) J:35259 Kameyama T, et al., Identification of plexin family molecules in mice. Biochem Biophys Res Commun. 1996 Sep 13;226(2):396-402
(Latest) J:218850 Bisson JA, et al., Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT. Dev Biol. 2015 Feb 1;398(1):80-96
All references(110)
Other
accession IDs
MGD-MRK-36259, MGI:1919991, MGI:2138117, MGI:2138589

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory