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Plxna2
Gene Detail
 Symbol
Name
ID
Plxna2
plexin A2
MGI:107684
Synonyms 2810428A13Rik, mKIAA0463, OCT, PlexA2, Plxn2
Feature Type protein coding gene
Genetic Map
Chromosome 1
98.27 cM, cytoband H6
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:194619829-194816869 bp, + strand
From VEGA annotation of GRCm38

  197041 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56427  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Plxna2

Human
homologs
Human Homolog PLXNA2, plexin A2
NCBI Gene ID 5362
neXtProt AC  NX_O75051
Human Synonyms  OCT, PLXN2
Human Chr (Location)  1q32.2; chr1:208022242-208244320 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show abnormal granule cell migration in the adult cerebellum and aberrant projection of mossy fibers in hippocampal slices. Mice homozygous for an ENU-induced allele are smaller and show granule cell migration defects and mild ataxia with incomplete penetrance.
 
Interactions
Plxna2 interacts with 466 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cell surface receptor signaling pathway, centrosome localization, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function receptor activity, semaphorin receptor activity
External Resources: FuncBase
Expression
Literature Summary: (62 records)
Data Summary: Results (216)    Tissues (126)    Images (61)
Theiler Stages: 2, 3, 4, 5, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 27, 28
Assay TypeResults
RNA in situ 207
Northern blot 1
RT-PCR 8
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) cDNA(23) Primer pair(1) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000017321 (Evidence)
Ensembl Gene ModelENSMUSG00000026640 (Evidence)
Entrez Gene18845 (Evidence)
DFCITC1579404, TC1583683, TC1619941, TC1626692
DoTSDT.40171084, DT.522492, DT.87059665, DT.91410254
PDB3OKT, 3OKY, 4GZA, 3AL8, 3AL9
Consensus CDS ProjectCCDS35827.1
International Mouse Knockout Project StatusPlxna2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017321 VEGA Gene Model | MGI Sequence Detail 197041 C57BL/6J ±  kb
transcript OTTMUST00000042096 VEGA | MGI Sequence Detail 11036 Not Applicable 
polypeptide OTTMUSP00000018927 VEGA | MGI Sequence Detail 1894 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(5) UniProt(3)
Polymorphisms SNPs within 2kb(830 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR002165 Plexin
InterPro IPR013548 Plexin, cytoplasmic RasGAP domain
InterPro IPR016201 Plexin-like fold
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR001627 Semaphorin/CD100 antigen
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000012893 plexin-A2
References (Earliest) J:35259 Kameyama T, et al., Identification of plexin family molecules in mice. Biochem Biophys Res Commun. 1996 Sep 13;226(2):396-402
(Latest) J:207861 Manthey AL, et al., Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development. Mech Dev. 2014 Feb;131:86-110
All references(105)
Other
accession IDs
MGD-MRK-36259, MGI:1919991, MGI:2138117, MGI:2138589

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory