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Plxna2 Gene Detail
Summary
  • Symbol
    Plxna2
  • Name
    plexin A2
  • Synonyms
    2810428A13Rik, mKIAA0463, OCT, PlexA2, Plxn2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107684
    NCBI Gene: 18845
  • Gene Overview
    MyGene.info: PLXNA2
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:194619829-194816869 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 98.27 cM, cytoband H6
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    828 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107684
 protein coding gene Chr1:194618218-194816869 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016965
 protein coding gene Chr1:201772937-201979146 (+)
A/J MGP_AJ_G0016944
 protein coding gene Chr1:193492479-193691376 (+)
AKR/J MGP_AKRJ_G0016909
 protein coding gene Chr1:199221155-199425804 (+)
BALB/cJ MGP_BALBcJ_G0016902
 protein coding gene Chr1:194180212-194380984 (+)
C3H/HeJ MGP_C3HHeJ_G0016726
 protein coding gene Chr1:200112412-200313869 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017365
 protein coding gene Chr1:208151787-208359849 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015072
 protein coding gene Chr1:184618028-184814053 (+)
CAST/EiJ MGP_CASTEiJ_G0016309
 protein coding gene Chr1:199677433-199879680 (+)
CBA/J MGP_CBAJ_G0016700
 protein coding gene Chr1:215835685-216049752 (+)
DBA/2J MGP_DBA2J_G0016806
 protein coding gene Chr1:192207919-192404684 (+)
FVB/NJ MGP_FVBNJ_G0016802
 protein coding gene Chr1:190307165-190504805 (+)
LP/J MGP_LPJ_G0016881
 protein coding gene Chr1:202929523-203136604 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016834
 protein coding gene Chr1:222479053-222687854 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017402
 protein coding gene Chr1:199071251-199280952 (+)
PWK/PhJ MGP_PWKPhJ_G0016096
 protein coding gene Chr1:191524600-191724281 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015872
 protein coding gene Chr1:198090083-198299669 (+)
WSB/EiJ MGP_WSBEiJ_G0016371
 protein coding gene Chr1:199354095-199556396 (+)



Homology
more
  • Human Ortholog
    PLXNA2, plexin A2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLXNA2, plexin A2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    OCT, PLXN2
  • Links
    NCBI Gene ID: 5362
    neXtProt AC: NX_O75051
    UniProt: O75051

  • Chr Location
    1q32.2; chr1:208022242-208244384 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 56427
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PLXNA2
  • Gene Tree
    Plxna2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 5 genetic backgrounds
    6 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show abnormal granule cell migration in the adult cerebellum and aberrant projection of mossy fibers in hippocampal slices. Mice homozygous for an ENU-induced allele are smaller and show granule cell migration defects and mild ataxia with incomplete penetrance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    229
  • Tissues
    135
  • cDNA Data
    23
  • Literature Summary
    81
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18845 NCBI Gene Model | MGI Sequence Detail 197041 C57BL/6J ±  kb
    transcript NM_008882 RefSeq | MGI Sequence Detail 11049 C57BL/6  
    polypeptide P70207 UniProt | EBI | MGI Sequence Detail 1894 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 24
      Primer pair 1
      Other 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-36259, MGI:1919991, MGI:2138117, MGI:2138589
    References
    more
    • Summaries
      All 130
      Developmental Gene Expression 81
      Gene Ontology 8
      Phenotypes 21
    • Earliest
      J:35259 Kameyama T, et al., Identification of plexin family molecules in mice. Biochem Biophys Res Commun. 1996 Sep 13;226(2):396-402
    • Latest
      J:271262 Zhao XF, et al., PlexinA2 Forward Signaling through Rap1 GTPases Regulates Dentate Gyrus Development and Schizophrenia-like Behaviors. Cell Rep. 2018 Jan 9;22(2):456-470
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2019
    MGI 6.13     		The Jackson Laboratory