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Plxna2 Gene Detail
Summary
  • Symbol
    Plxna2
  • Name
    plexin A2
  • Synonyms
    2810428A13Rik, mKIAA0463, OCT, PlexA2, Plxn2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107684
    NCBI Gene: 18845
  • Gene Overview
    MyGene.info: PLXNA2
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr1:194618218-194816869 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      198652 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 98.27 cM, cytoband H6
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PLXNA2, plexin A2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLXNA2, plexin A2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    OCT, PLXN2
  • Links
    NCBI Gene ID: 5362
    neXtProt AC: NX_O75051
    UniProt: O75051

  • Chr Location
    1q32.2; chr1:208022242-208244384 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 56427
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PLXNA2
  • Gene Tree
    Plxna2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 3 alleles in 5 genetic backgrounds
    6 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show abnormal granule cell migration in the adult cerebellum and aberrant projection of mossy fibers in hippocampal slices. Mice homozygous for an ENU-induced allele are smaller and show granule cell migration defects and mild ataxia with incomplete penetrance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    221
  • Tissues
    129
  • cDNA Data
    22
  • Literature Summary
    77
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017321 VEGA Gene Model | MGI Sequence Detail 198652 C57BL/6J ±  kb
transcript OTTMUST00000042096 VEGA | MGI Sequence Detail 11040 Not Applicable  
polypeptide OTTMUSP00000018927 VEGA | MGI Sequence Detail 1894 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    835 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 26
    cDNA 23
    Primer pair 1
    Other 2

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-36259, MGI:1919991, MGI:2138117, MGI:2138589
References
more
  • Summaries
    All 124
    Developmental Gene Expression 77
    Gene Ontology 7
    Phenotypes 20
  • Earliest
    J:35259 Kameyama T, et al., Identification of plexin family molecules in mice. Biochem Biophys Res Commun. 1996 Sep 13;226(2):396-402
  • Latest
    J:245924 Pauerstein PT, et al., A radial axis defined by semaphorin-to-neuropilin signaling controls pancreatic islet morphogenesis. Development. 2017 Oct 15;144(20):3744-3754
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/17/2018
MGI 6.11 		The Jackson Laboratory