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Ifna1 Gene Detail
Summary
  • Symbol
    Ifna1
  • Name
    interferon alpha 1
  • Synonyms
    Ifa1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107668
    NCBI Gene: 15962
  • Member of
    Ifna cluster
  • Gene Overview
    MyGene.info: IFNA4
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr4:88850087-88850656 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 42.04 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    56 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107668
protein coding gene Chr4:88850087-88850656 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028429
protein coding gene Chr4:88538401-88538970 (-)
A/J MGP_AJ_G0028390
protein coding gene Chr4:85457075-85457644 (-)
AKR/J MGP_AKRJ_G0028347
protein coding gene Chr4:87770964-87771532 (+)
BALB/cJ MGP_BALBcJ_G0028418
protein coding gene Chr4:85871020-85871541 (+)
C3H/HeJ MGP_C3HHeJ_G0028122
protein coding gene Chr4:88290092-88290661 (-)
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0028093
protein coding gene Chr4:94750312-94750881 (-)
DBA/2J MGP_DBA2J_G0028243
protein coding gene Chr4:85234565-85235134 (-)
FVB/NJ MGP_FVBNJ_G0028208
protein coding gene Chr4:84166147-84166716 (-)
LP/J MGP_LPJ_G0028350
protein coding gene Chr4:89047730-89048298 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028238
protein coding gene Chr4:99764977-99765546 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028895
protein coding gene Chr4:87914848-87915417 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0027110
protein coding gene Chr4:85231413-85232659 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    IFNA4, interferon alpha 4
  • Vertebrate Orthologs
    25
  • Human Ortholog
    IFNA4, interferon alpha 4
    Orthology source: HomoloGene
  • Synonyms
    IFN-alpha4a, INFA4
  • Links
    NCBI Gene ID: 3441
    neXtProt AC: NX_P05014
    UniProt: P05014

  • Chr Location
    9p21.3; chr9:21186618-21187599 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15962 NCBI Gene Model | MGI Sequence Detail 570 C57BL/6J ±  kb
    transcript NM_010502 RefSeq | MGI Sequence Detail 570 Not Specified  
    polypeptide P01572 UniProt | EBI | MGI Sequence Detail 189 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 7
      cDNA 2
      Primer pair 2
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11201, MGD-MRK-36243
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:25569 Aguet M, High-affinity binding of 125I-labelled mouse interferon to a specific cell surface receptor. Nature. 1980 Apr 3;284(5755):459-61
    • Latest
      J:238756 Kavanagh D, et al., Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature. Blood. 2016 Dec 15;128(24):2824-2833

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory