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Ifna6 Gene Detail
Summary
  • Symbol
    Ifna6
  • Name
    interferon alpha 6
  • Synonyms
    Ifa6, Ifna8
  • Feature Type
    protein coding gene
  • IDs
    MGI:107662
    NCBI Gene: 15969
  • Member of
    Ifna cluster
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr4:88745653-88746222 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 42.03 cM
  • Mapping Data
    5 experiments
Strain
Comparison
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  • SNPs within 2kb
    51 from dbSNP Build 142
  • Strain Annotations
    10
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107662
protein coding gene Chr4:88745513-88746269 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0028398
protein coding gene Chr4:85632123-85632805 (+)
AKR/J MGP_AKRJ_G0028345
protein coding gene Chr4:87753847-87754489 (+)
BALB/cJ MGP_BALBcJ_G0028416
protein coding gene Chr4:85853535-85854177 (+)
C3H/HeJ MGP_C3HHeJ_G0028129
protein coding gene Chr4:88468245-88468907 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028855
protein coding gene Chr4:92116245-92116814 (+)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0028099
protein coding gene Chr4:94966870-94967482 (+)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0028215
protein coding gene Chr4:84322005-84322574 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0028245
protein coding gene Chr4:99943766-99944335 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028892
protein coding gene Chr4:87887069-87887638 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
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  • Human Ortholog
    IFNA10, interferon alpha 10
  • Vertebrate Orthologs
    14
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFNA10, interferon alpha 10
  • Synonyms
    IFN-alphaC
  • Links
    NCBI Gene ID: 3446
    neXtProt AC: NX_P01566
    UniProt: P01566

  • Chr Location
    9p21.3; chr9:21206181-21207143 (-)  GRCh38.p7

  • Human Ortholog
    IFNA13, interferon alpha 13
  • Links
    NCBI Gene ID: 3447
    neXtProt AC: NX_P01562
    UniProt: P01562

  • Chr Location
    9p21.3; chr9:21367372-21368076 (-)  GRCh38.p7

  • Human Ortholog
    IFNA14, interferon alpha 14
  • Synonyms
    IFN-alphaH, LEIF2H
  • Links
    NCBI Gene ID: 3448
    neXtProt AC: NX_P01570
    UniProt: P01570

  • Chr Location
    9p21.3; chr9:21239202-21239979 (-)  GRCh38.p7

  • Human Ortholog
    IFNA16, interferon alpha 16
  • Synonyms
    IFN-alpha-16, IFN-alphaO
  • Links
    NCBI Gene ID: 3449
    neXtProt AC: NX_P05015
    UniProt: P05015

  • Chr Location
    9p21.3; chr9:21216373-21217311 (-)  GRCh38.p7

  • Human Ortholog
    IFNA17, interferon alpha 17
  • Synonyms
    IFNA, IFN-alphaI, INFA, LEIF2C1
  • Links
    NCBI Gene ID: 3451
    neXtProt AC: NX_P01571
    UniProt: P01571

  • Chr Location
    9p21.3; chr9:21227243-21228222 (-)  GRCh38.p7

  • Human Ortholog
    IFNA2, interferon alpha 2
  • Synonyms
    IFNA, IFNA2B, IFN-alpha-2, IFN-alphaA, leIF A
  • Links
    NCBI Gene ID: 3440
    neXtProt AC: NX_P01563
    UniProt: P01563

  • Chr Location
    9p21.3; chr9:21384255-21385397 (-)  GRCh38.p7

  • Human Ortholog
    IFNA21, interferon alpha 21
  • Synonyms
    IFN-alphaI, leIF-F, LeIF F
  • Links
    NCBI Gene ID: 3452
    neXtProt AC: NX_P01568
    UniProt: P01568

  • Chr Location
    9p21.3; chr9:21165637-21166660 (-)  GRCh38.p7

  • Human Ortholog
    IFNA4, interferon alpha 4
  • Synonyms
    IFN-alpha4a, INFA4
  • Links
    NCBI Gene ID: 3441
    neXtProt AC: NX_P05014
    UniProt: P05014

  • Chr Location
    9p21.3; chr9:21186618-21187599 (-)  GRCh38.p7

  • Human Ortholog
    IFNA6, interferon alpha 6
  • Synonyms
    IFN-alphaK
  • Links
    NCBI Gene ID: 3443
    neXtProt AC: NX_P05013
    UniProt: P05013

  • Chr Location
    9p21.3; chr9:21350318-21350887 (-)  GRCh38.p7

  • Human Ortholog
    IFNA7, interferon alpha 7
  • Synonyms
    IFNA-J, IFN-alphaJ
  • Links
    NCBI Gene ID: 3444
    neXtProt AC: NX_P01567
    UniProt: P01567

  • Chr Location
    9p21.3; chr9:21201469-21202205 (-)  GRCh38.p7

  • Human Ortholog
    IFNA8, interferon alpha 8
  • Synonyms
    IFN-alphaB
  • Links
    NCBI Gene ID: 3445
    neXtProt AC: NX_P32881
    UniProt: P32881

  • Chr Location
    9p21.3; chr9:21409147-21410185 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    9 phenotype references
Mice heterozygous for reporter allele are viable and fertile, and show normal production of interferon-alpha in response to viral infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000101252 Ensembl Gene Model | MGI Sequence Detail 570 C57BL/6J ±  kb
transcript ENSMUST00000105146 Ensembl | MGI Sequence Detail 570 Not Applicable  
polypeptide ENSMUSP00000100777 Ensembl | MGI Sequence Detail 189 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR009079 Four-helical cytokine-like, core
    IPR000471 Interferon alpha/beta/delta
Molecular
Reagents
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  • All nucleic 12
    Genomic 6
    cDNA 4
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11207, MGD-MRK-11209, MGD-MRK-36235, MGD-MRK-36237, MGI:107660
References
more
  • Summaries
    All 35
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:7878 Zwarthoff EC, et al., Organization, structure and expression of murine interferon alpha genes. Nucleic Acids Res. 1985 Feb 11;13(3):791-804
  • Latest
    J:243847 Webb LM, et al., Type I interferon is required for T helper (Th) 2 induction by dendritic cells. EMBO J. 2017 Aug 15;36(16):2404-2418

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory