About   Help   FAQ
Ifna6 Gene Detail
Summary
  • Symbol
    Ifna6
  • Name
    interferon alpha 6
  • Synonyms
    Ifa6, Ifna8
  • Feature Type
    protein coding gene
  • IDs
    MGI:107662
    NCBI Gene: 15969
  • Member of
    Ifna cluster
  • Gene Overview
    MyGene.info: IFNA4
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr4:88827416-88827985 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 42.03 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    62 from dbSNP Build 142
  • Strain Annotations
    10
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107662
protein coding gene Chr4:88827276-88828032 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0028398
protein coding gene Chr4:85632123-85632805 (+)
AKR/J MGP_AKRJ_G0028345
protein coding gene Chr4:87753847-87754489 (+)
BALB/cJ MGP_BALBcJ_G0028416
protein coding gene Chr4:85853535-85854177 (+)
C3H/HeJ MGP_C3HHeJ_G0028129
protein coding gene Chr4:88468245-88468907 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028855
protein coding gene Chr4:92116245-92116814 (+)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0028099
protein coding gene Chr4:94966870-94967482 (+)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0028215
protein coding gene Chr4:84322005-84322574 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0028245
protein coding gene Chr4:99943766-99944335 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028892
protein coding gene Chr4:87887069-87887638 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    IFNA4, interferon alpha 4
  • Vertebrate Orthologs
    25
  • Human Ortholog
    IFNA4, interferon alpha 4
    Orthology source: HomoloGene
  • Synonyms
    IFN-alpha4a, INFA4
  • Links
    NCBI Gene ID: 3441
    neXtProt AC: NX_P05014
    UniProt: P05014

  • Chr Location
    9p21.3; chr9:21186618-21187599 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    9 phenotype references
Mice heterozygous for reporter allele are viable and fertile, and show normal production of interferon-alpha in response to viral infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000101252 Ensembl Gene Model | MGI Sequence Detail 570 C57BL/6J ±  kb
transcript ENSMUST00000105146 Ensembl | MGI Sequence Detail 570 Not Applicable  
polypeptide ENSMUSP00000100777 Ensembl | MGI Sequence Detail 189 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR009079 Four-helical cytokine-like, core
    IPR000471 Interferon alpha/beta/delta
Molecular
Reagents
less
  • All nucleic 12
    Genomic 6
    cDNA 4
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11207, MGD-MRK-11209, MGD-MRK-36235, MGD-MRK-36237, MGI:107660
References
more
  • Summaries
    All 36
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:7878 Zwarthoff EC, et al., Organization, structure and expression of murine interferon alpha genes. Nucleic Acids Res. 1985 Feb 11;13(3):791-804
  • Latest
    J:243847 Webb LM, et al., Type I interferon is required for T helper (Th) 2 induction by dendritic cells. EMBO J. 2017 Aug 15;36(16):2404-2418

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/16/2021
MGI 6.16
The Jackson Laboratory