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Ifngr1 Gene Detail
Summary
  • Symbol
    Ifngr1
  • Name
    interferon gamma receptor 1
  • Synonyms
    CD119, Ifgr, IFN-gamma R, IFN-gammaR, Ifngr, Nktar
  • Feature Type
    protein coding gene
  • IDs
    MGI:107655
    NCBI Gene: 15979
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:19467697-19485977 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 8.49 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    627 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107655
 protein coding gene Chr10:19467697-19485977 (+)
129S1/SvImJ ENSMUSG00200009975
 protein coding gene Chr10:16464735-16483133 (+)
A/J ENSMUSG00195006669
 protein coding gene Chr10:16481543-16499719 (+)
AKR/J ENSMUSG00220010088
 protein coding gene Chr10:16386995-16405279 (+)
BALB/cJ ENSMUSG00180014374
 protein coding gene Chr10:16605777-16623956 (+)
C3H/HeJ ENSMUSG00175019658
 protein coding gene Chr10:16625602-16643778 (+)
C57BL/6NJ ENSMUSG00215003503
 protein coding gene Chr10:16419695-16437973 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015148
 protein coding gene Chr10:15667367-15685321 (+)
CAST/EiJ ENSTCUG00005029258
 protein coding gene Chr10:16387843-16406117 (+)
CBA/J ENSMUSG00210015176
 protein coding gene Chr10:16563238-16581414 (+)
DBA/2J ENSMUSG00185007087
 protein coding gene Chr10:16547757-16565935 (+)
FVB/NJ ENSMUSG00205014462
 protein coding gene Chr10:16460240-16478520 (+)
JF1/MsJ ENSUMUG00000007756
 protein coding gene Chr10:16609597-16627211 (+)
LP/J ENSMUSG00230017007
 protein coding gene Chr10:18203708-18221884 (+)
NOD/ShiLtJ ENSMUSG00190010231
 protein coding gene Chr10:16530941-16549221 (+)
NZO/HlLtJ ENSMUSG00225029487
 protein coding gene Chr10:22678473-22696757 (+)
PWK/PhJ ENSLUMG00010015048
 protein coding gene Chr10:16375286-16392831 (+)
SPRET/EiJ ENSMSPG00010010045
 protein coding gene Chr10:16985257-17004023 (+)
WSB/EiJ ENSIUOG00005020789
 protein coding gene Chr10:16170907-16189398 (+)



Homology
more
  • Human Ortholog
    IFNGR1, interferon gamma receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFNGR1, interferon gamma receptor 1
  • Synonyms
    CD119, IFNGR, IMD27A, IMD27B
  • Links
    NCBI Gene ID: 3459
    UniProt: P15260

  • Chr Location
    6q23.3; chr6:137197483-137219449 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ifngr1 mouse models; 6 with human IFNGR1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    84 phenotypes from 7 alleles in 14 genetic backgrounds
    33 phenotypes from multigenic genotypes
    3 images
    816 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a mutant allele exhibit increased susceptibility to viral infection and experimental autoimmune uveoretinitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    863
  • Tissues
    37
  • cDNA Data
    112
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15979 NCBI Gene Model | MGI Sequence Detail 18281 C57BL/6J ±  kb
    transcript NM_010511 RefSeq | MGI Sequence Detail 2126 ZRU/MplStud  
    polypeptide P15261 UniProt | EBI | MGI Sequence Detail 477 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 112
      cDNA 112
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11215, MGD-MRK-36230
    References
    more
    • Summaries
      All 923
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 14
      Phenotypes 816
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:391845 Martin T, et al., Ovarian localization drives IL-7R-dependent CD8 coreceptor expression in peripheral double-negative T cells. Cell Mol Life Sci. 2026 Jun 16;83(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory