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Ifngr1 Gene Detail
Summary
  • Symbol
    Ifngr1
  • Name
    interferon gamma receptor 1
  • Synonyms
    CD119, Ifgr, IFN-gammaR, IFN-gamma R, Ifngr, Nktar
  • Feature Type
    protein coding gene
  • IDs
    MGI:107655
    NCBI Gene: 15979
Location & Maps
more
  • Sequence Map
    Chr10:19591949-19610229 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18281 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    IFNGR1, interferon gamma receptor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IFNGR1, interferon gamma receptor 1
    Orthology source: HomoloGene
  • Synonyms
    CD119, IFNGR, IMD27A, IMD27B
  • Links
    NCBI Gene ID: 3459
    neXtProt AC: NX_P15260

  • Chr Location
    6q23.3; chr6:137197484-137219844 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    5 with human IFNGR1 associations

Human Disease Mouse Models
       Helicobacter Pylori Infection, Susceptibility to   OMIM: 600263
Hepatitis B Virus, Susceptibility to   OMIM: 610424
Immunodeficiency 27a; IMD27A   OMIM: 209950
Immunodeficiency 27b; IMD27B   OMIM: 615978
Mycobacterium Tuberculosis, Susceptibility to   OMIM: 607948
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    57 phenotypes from 5 alleles in 11 genetic backgrounds
    30 phenotypes from multigenic genotypes
    3 images
    397 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Targeted
    7
  • Genomic Mutations
    1 involving Ifngr1
  • Incidental Mutations
Mice homozygous for a mutant allele exhibit increased susceptibility to viral infection and experimental autoimmune uveoretinitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035345 VEGA Gene Model | MGI Sequence Detail 18281 C57BL/6J ±  kb
transcript OTTMUST00000090213 VEGA | MGI Sequence Detail 2112 Not Applicable  
polypeptide OTTMUSP00000049447 VEGA | MGI Sequence Detail 477 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    125 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000001361 interferon gamma receptor alpha chain
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR013783 Immunoglobulin-like fold
    IPR008355 Interferon gamma receptor alpha subunit
    IPR021126 Interferon gamma receptor, poxvirus/mammal
Molecular
Reagents
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  • All nucleic 113
    cDNA 113

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11215, MGD-MRK-36230
References
more
  • Summaries
    All 459
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 397
  • Earliest
    J:8684 Mariano TM, et al., The mouse immune interferon receptor gene is located on chromosome 10. J Biol Chem. 1987 Apr 25;262(12):5812-4
  • Latest
    J:225614 Hunemorder S, et al., TH1 and TH17 cells promote crescent formation in experimental autoimmune glomerulonephritis. J Pathol. 2015 Sep;237(1):62-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory