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Ifngr2 Gene Detail
Summary
  • Symbol
    Ifngr2
  • Name
    interferon gamma receptor 2
  • Synonyms
    Ifgr2, Ifgt
  • Feature Type
    protein coding gene
  • IDs
    MGI:107654
    NCBI Gene: 15980
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:91547094-91564007 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 53.07 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    36 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107654
protein coding gene Chr16:91547072-91565169 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023042
protein coding gene Chr16:92568698-92586422 (+)
A/J MGP_AJ_G0023010
protein coding gene Chr16:88240821-88258802 (+)
AKR/J MGP_AKRJ_G0022980
protein coding gene Chr16:90902616-90920713 (+)
BALB/cJ MGP_BALBcJ_G0023012
protein coding gene Chr16:88765982-88785231 (+)
C3H/HeJ MGP_C3HHeJ_G0022773
protein coding gene Chr16:91478361-91500622 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023459
protein coding gene Chr16:95558060-95578329 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020961
protein coding gene Chr16:85931667-85951541 (+)
CAST/EiJ MGP_CASTEiJ_G0022292
protein coding gene Chr16:92040286-92061353 (+)
CBA/J MGP_CBAJ_G0022742
protein coding gene Chr16:99634447-99658217 (+)
DBA/2J MGP_DBA2J_G0022876
protein coding gene Chr16:88141841-88160011 (+)
FVB/NJ MGP_FVBNJ_G0022850
protein coding gene Chr16:87269263-87287893 (+)
LP/J MGP_LPJ_G0022946
protein coding gene Chr16:92272545-92290903 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022871
protein coding gene Chr16:104190004-104211391 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023477
protein coding gene Chr16:91424369-91442614 (+)
PWK/PhJ MGP_PWKPhJ_G0022037
protein coding gene Chr16:88317371-88337069 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021867
protein coding gene Chr16:90985290-91003270 (+)
WSB/EiJ MGP_WSBEiJ_G0022344
protein coding gene Chr16:91666720-91686167 (+)



Homology
more
  • Human Ortholog
    IFNGR2, interferon gamma receptor 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IFNGR2, interferon gamma receptor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AF-1, IFGR2, IFNGT1, IMD28
  • Links
    NCBI Gene ID: 3460
    neXtProt AC: NX_P38484
    UniProt: P38484

  • Chr Location
    21q22.11; chr21:33402896-33437521 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Ifngr2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 5 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene develop normally.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15980 NCBI Gene Model | MGI Sequence Detail 16914 C57BL/6J ±  kb
    transcript NM_008338 RefSeq | MGI Sequence Detail 2105 C57BL/6  
    polypeptide NP_032364 RefSeq | MGI Sequence Detail 332 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR013783 Immunoglobulin-like fold
      IPR015373 Interferon/interleukin receptor domain
    Molecular
    Reagents
    less
    • All nucleic 62
      Genomic 1
      cDNA 57
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11216, MGD-MRK-25614, MGD-MRK-36229
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 3
      Phenotypes 27
    • Earliest
      J:11127 Hibino Y, et al., Expression and reconstitution of a biologically active mouse interferon gamma receptor in hamster cells. Chromosomal location of an accessory factor. J Biol Chem. 1991 Apr 15;266(11):6948-51
    • Latest
      J:263559 Yun K, et al., Constitutive metanephric mesenchyme-specific expression of interferon-gamma causes renal dysplasia by regulating Sall1 expression. PLoS One. 2018;13(5):e0197356

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory