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Ifngr2 Gene Detail
Summary
  • Symbol
    Ifngr2
  • Name
    interferon gamma receptor 2
  • Synonyms
    Ifgr2, Ifgt
  • Feature Type
    protein coding gene
  • IDs
    MGI:107654
    NCBI Gene: 15980
Location & Maps
more
  • Sequence Map
    Chr16:91547072-91565169 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18098 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 53.07 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    IFNGR2, interferon gamma receptor 2 (interferon gamma transducer 1)
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IFNGR2, interferon gamma receptor 2 (interferon gamma transducer 1)
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AF-1, IFGR2, IFNGT1, IMD28
  • Links
    NCBI Gene ID: 3460
    neXtProt AC: NX_P38484

  • Chr Location
    21q22.11; chr21:33402896-33437521 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Ifngr2 mouse models; 1 with human IFNGR2 associations

Human Disease Mouse Models
       Diabetes Mellitus, Insulin-Dependent; IDDM   OMIM: 222100 View 1 model
       Immunodeficiency 28; IMD28   OMIM: 614889
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 3 alleles in 5 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Targeted
    10
  • Transgenic
    2
  • Genomic Mutations
    6 involving Ifngr2
Mice homozygous for disruptions in this gene develop normally.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028337 VEGA Gene Model | MGI Sequence Detail 18098 C57BL/6J ±  kb
transcript OTTMUST00000070230 VEGA | MGI Sequence Detail 3254 Not Applicable  
polypeptide OTTMUSP00000035758 VEGA | MGI Sequence Detail 332 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    44 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR013783 Immunoglobulin-like fold
    IPR015373 Interferon/interleukin receptor domain
Molecular
Reagents
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  • All nucleic 60
    Genomic 1
    cDNA 56
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-11216, MGD-MRK-25614, MGD-MRK-36229
References
more
  • Summaries
    All 58
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 3
    Phenotypes 25
  • Earliest
    J:11127 Hibino Y, et al., Expression and reconstitution of a biologically active mouse interferon gamma receptor in hamster cells. Chromosomal location of an accessory factor. J Biol Chem. 1991 Apr 15;266(11):6948-51
  • Latest
    J:232829 Zhao Y, et al., Mouse pancreatic beta cells express MHC class II and stimulate CD4(+) T cells to proliferate. Eur J Immunol. 2015 Sep;45(9):2494-503

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory