Phenotypes Associated with This Genotype

Genotype
MGI:3603845

• Allelic Composition: Ifngr2^tm1Pbro/Ifngr2^tm1Pbro
• Genetic Background: NOD.129S1-Ifngr2^tm1Pbro

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal diapedesis ( J:72818 )

• CD8+ T cells injected into Ifngr2-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis

immune system

abnormal diapedesis ( J:72818 )

• CD8+ T cells injected into Ifngr2-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis

abnormal T-helper 2 physiology ( J:65986 )

• enhanced Th2 responses

abnormal cytotoxic T cell physiology ( J:72818 )

• CD8+ T cells injected into Ifngr2-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis

decreased susceptibility to autoimmune diabetes ( J:72818 )

• when diabetogenic splenocytes are injected into Ifngr2-deficient NOD mice, diabetes development is delayed compared to wild-type NOD mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:65986 )

N • unexpectedly, incidence of type 1 diabetes in females was unchanged

hematopoietic system

abnormal diapedesis ( J:72818 )

• CD8+ T cells injected into Ifngr2-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis

abnormal T-helper 2 physiology ( J:65986 )

• enhanced Th2 responses

abnormal cytotoxic T cell physiology ( J:72818 )

• CD8+ T cells injected into Ifngr2-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:72818