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Mvk
Gene Detail
 Symbol
Name
ID
Mvk
mevalonate kinase
MGI:107624
Synonyms 2310010A05Rik
Feature Type protein coding gene
Genetic Map
Chromosome 5
55.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr5:114444269-114460591 bp, + strand
From VEGA annotation of GRCm38

  16323 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:372  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: mevalonate kinase/phosphomevalonate kinase
Gene Tree: Mvk

Human
homologs
Human Homolog MVK, mevalonate kinase
NCBI Gene ID 4598
neXtProt AC  NX_Q03426
Human Synonyms  LRBP, MK, MVLK, POROK3
Human Chr (Location)  12q24; chr12:109573695-109597266 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human MVK
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(5)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Mvk interacts with 43 markers (Mir18, Mir18b, Mir28b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cholesterol biosynthetic process, cholesterol metabolic process, ...
Component cytoplasm, cytosol, ...
Function ATP binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (236)    Tissues (140)    Images (44)
Theiler Stages: 11, 13, 22, 23, 26, 28
Assay TypeResults
RNA in situ 236
cDNA source data(44)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) cDNA(47) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000014479 (Evidence)
Ensembl Gene ModelENSMUSG00000041939 (Evidence)
Entrez Gene17855 (Evidence)
UniGene28088
DFCITC1579065, TC1609810
DoTSDT.101249895, DT.101367964, DT.487526, DT.55200540
NIA Mouse Gene IndexU006032
EC2.7.1.36
Consensus CDS ProjectCCDS19566.1
International Mouse Knockout Project StatusMvk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014479 VEGA Gene Model | MGI Sequence Detail 16323 C57BL/6J ±  kb
transcript OTTMUST00000034383 VEGA | MGI Sequence Detail 1602 Not Applicable 
polypeptide OTTMUSP00000015401 VEGA | MGI Sequence Detail 407 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(8) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(184 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006203 GHMP kinase, ATP-binding, conserved site
InterPro IPR013750 GHMP kinase, C-terminal domain
InterPro IPR006204 GHMP kinase N-terminal domain
InterPro IPR006206 Mevalonate/galactokinase
InterPro IPR006205 Mevalonate kinase
InterPro IPR020568 Ribosomal protein S5 domain 2-type fold
InterPro IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
Protein Ontology PR:000010786 mevalonate kinase
References (Earliest) J:34178 Welch CL, et al., Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes. J Lipid Res. 1996 Jul;37(7):1406-21
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(46)
Other
accession IDs
MGD-MRK-36198, MGI:1917348, MGI:2140825, MGI:2140856

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory