About   Help   FAQ
Mvk Gene Detail
Summary
  • Symbol
    Mvk
  • Name
    mevalonate kinase
  • Synonyms
    2310010A05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:107624
    NCBI Gene: 17855
  • Gene Overview
    MyGene.info: MVK
Location & Maps
more
  • Sequence Map
    Chr5:114444269-114460591 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16323 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MVK, mevalonate kinase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MVK, mevalonate kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LRBP, MK, MVLK, POROK3
  • Links
    NCBI Gene ID: 4598
    neXtProt AC: NX_Q03426

  • Chr Location
    12q24; chr12:109573353-109597270 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with human MVK associations

Human Disease Mouse Models
       Hyper-IgD Syndrome; HIDS   OMIM: 260920
Mevalonic Aciduria; MEVA   OMIM: 610377
Porokeratosis 3, Multiple Types; POROK3   OMIM: 175900
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Mvk
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014479 VEGA Gene Model | MGI Sequence Detail 16323 C57BL/6J ±  kb
transcript OTTMUST00000034383 VEGA | MGI Sequence Detail 1602 Not Applicable  
polypeptide OTTMUSP00000015401 VEGA | MGI Sequence Detail 407 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    183 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 48
    cDNA 47
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-36198, MGI:1917348, MGI:2140825, MGI:2140856
References
more
  • Summaries
    All 44
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:34178 Welch CL, et al., Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes. J Lipid Res. 1996 Jul;37(7):1406-21
  • Latest
    J:224387 Sisecioglu M, et al., A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo. J Lipid Res. 2015 Aug;56(8):1551-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory