Mvk
Gene Detail

Symbol Name ID

Mvk mevalonate kinase MGI:107624

Synonyms

2310010A05Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 5

55.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr5:114444269-114460591 bp, + strand From VEGA annotation of GRCm38   16323 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:372  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 zebrafish

Protein SuperFamily: mevalonate kinase/phosphomevalonate kinase
Gene Tree: Mvk

Human homologs

Human Homolog		MVK, mevalonate kinase
NCBI Gene ID		4598
neXtProt AC		NX_Q03426
Human Synonyms		LRBP, MK, MVLK, POROK3
Human Chr (Location)		12q24; chr12:110011500-110035071 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human MVK

Alleles and phenotypes

All alleles(5) : Gene trapped(5)

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	cholesterol biosynthetic process, cholesterol metabolic process, ...
Component	cytoplasm, cytosol
Function	identical protein binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (208)    Tissues (112)    Images (42)
Theiler Stages: 11, 13, 22, 23

Assay Type	Results
RNA in situ	208

cDNA source data(44)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(48) cDNA(47) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000014479 (Evidence)
Ensembl Gene Model	ENSMUSG00000041939 (Evidence)
Entrez Gene	17855 (Evidence)
UniGene	28088
DFCI	TC1579065, TC1609810
DoTS	DT.101249895, DT.101367964, DT.487526, DT.55200540
NIA Mouse Gene Index	U006032
EC	2.7.1.36
Consensus CDS Project	CCDS19566.1
International Mouse Knockout Project Status	Mvk

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014479	VEGA Gene Model | MGI Sequence Detail	16323	C57BL/6J
transcript	OTTMUST00000034383	VEGA | MGI Sequence Detail	1602	Not Applicable
polypeptide	OTTMUSP00000015401	VEGA | MGI Sequence Detail	407	Not Applicable

All sequences(46) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(145 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006203	GHMP kinase, ATP-binding, conserved site
InterPro	IPR013750	GHMP kinase, C-terminal domain
InterPro	IPR006204	GHMP kinase N-terminal domain
InterPro	IPR006206	Mevalonate/galactokinase
InterPro	IPR006205	Mevalonate kinase
InterPro	IPR020568	Ribosomal protein S5 domain 2-type fold
InterPro	IPR014721	Ribosomal protein S5 domain 2-type fold, subgroup
Protein Ontology	PR:000010786	mevalonate kinase

References

(Earliest) J:34178 Welch CL, et al., Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes. J Lipid Res. 1996 Jul;37(7):1406-21
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(44)

Other accession IDs

MGD-MRK-36198, MGI:1917348, MGI:2140825, MGI:2140856