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Mvk
Gene Detail
Symbol

Name
ID
Mvk
mevalonate kinase
MGI:107624
Synonyms
2310010A05Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 5
55.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr5:114444269-114460591 bp, + strand
From VEGA annotation of GRCm38

  16323 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:372  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MVK
Protein SuperFamily: mevalonate kinase/phosphomevalonate kinase
Gene Tree: Mvk

Human
homologs
MVK, mevalonate kinase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4598
neXtProt AC: NX_Q03426

Human Synonyms: LRBP, MK, MVLK, POROK3

Human Chr (Location): 12q24; chr12:109573353-109597270 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human MVK

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(5)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Mvk interacts with 43 markers (Mir18, Mir18b, Mir28b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cholesterol biosynthetic process, cholesterol metabolic process, ...
Component cytoplasm, cytosol, ...
Function ATP binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (236)    Tissues (140)    Images (44)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 236
cDNA source data(44)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mvk ; ZFIN mvk    NEW 
Molecular
reagents
All nucleic(48) cDNA(47) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000014479 (Evidence)
Ensembl Gene Model ENSMUSG00000041939 (Evidence)
Entrez Gene 17855 (Evidence)
UniGene 28088
DFCI TC1579065, TC1609810
DoTS DT.55200540, DT.487526, DT.101367964, DT.101249895
NIA Mouse Gene Index U006032
EC 2.7.1.36
Consensus CDS Project CCDS19566.1
International Mouse Phenotyping Consortium Status Mvk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014479 VEGA Gene Model | MGI Sequence Detail 16323 C57BL/6J ±  kb
transcript OTTMUST00000034383 VEGA | MGI Sequence Detail 1602 Not Applicable 
polypeptide OTTMUSP00000015401 VEGA | MGI Sequence Detail 407 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(8) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(184 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006203 GHMP kinase, ATP-binding, conserved site
InterPro IPR013750 GHMP kinase, C-terminal domain
InterPro IPR006204 GHMP kinase N-terminal domain
InterPro IPR006206 Mevalonate/galactokinase
InterPro IPR006205 Mevalonate kinase
InterPro IPR020568 Ribosomal protein S5 domain 2-type fold
InterPro IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
Protein Ontology PR:000010786 mevalonate kinase
References
(Earliest) J:34178 Welch CL, et al., Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes. J Lipid Res. 1996 Jul;37(7):1406-21
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(45)
Other
accession IDs
MGD-MRK-36198, MGI:1917348, MGI:2140825, MGI:2140856

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory