Mvk Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mvk
mevalonate kinase
MGI:107624

32 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mvk^em1(IMPC)Tcp/Mvk⁺ C57BL/6NCrl-Mvk^em1(IMPC)Tcp/Tcp	abnormal embryo size	J:211773
	hydrometra	J:211773
	microphthalmia	J:211773
	small epididymis	J:211773
	small seminal vesicle	J:211773
	small testis	J:211773
Mvk^em1(IMPC)Tcp/Mvk^em1(IMPC)Tcp C57BL/6NCrl-Mvk^em1(IMPC)Tcp/Tcp	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Mvk^em1Mijr/Mvk⁺ C57BL/6J-Mvk^em1Mijr	abnormal enzyme/coenzyme activity	J:371663
Mvk^em1Mijr/Mvk^em1Mijr C57BL/6J-Mvk^em1Mijr	abnormal enzyme/coenzyme activity	J:371663
Mvk^em1Mijr/Mvk^em4Mijr C57BL/6J-Mvk^em1Mijr Mvk^em4Mijr	abnormal enzyme/coenzyme activity	J:371663
	abnormal inflammatory response	J:371663
	abnormal metabolism	J:371663
	normal immune system phenotype	J:371663
	increased susceptibility to endotoxin shock	J:371663
Mvk^em2Mijr/Mvk^em2Mijr C57BL/6J-Mvk^em2Mijr	prenatal lethality, complete penetrance	J:371663
Mvk^em3Mijr/Mvk^em3Mijr C57BL/6J-Mvk^em3Mijr	prenatal lethality, complete penetrance	J:371663
Mvk^em4Mijr/Mvk⁺ C57BL/6J-Mvk^em4Mijr	abnormal enzyme/coenzyme activity	J:371663
Mvk^em4Mijr/Mvk^em4Mijr C57BL/6J-Mvk^em4Mijr	prenatal lethality, complete penetrance	J:371663
Mvk^{Gt(OST201716)Lex}/Mvk⁺ involves: 129S5/SvEvBrd * C57BL/6	abnormal body temperature homeostasis	J:371688
	abnormal coat appearance	J:371688
	abnormal enzyme/coenzyme activity	J:371688
	abnormal erythrocyte basophilic stippling	J:371688
	abnormal homeostasis	J:371688
	abnormal IgA level	J:371688
	abnormal megakaryocyte morphology	J:371688
	decreased aggression	J:371688
	decreased bone marrow cell number	J:371688
	decreased locomotor activity	J:371688
	decreased neutrophil cell number	J:371688
	enlarged liver	J:371688
	enlarged spleen	J:371688
	fragile skeleton	J:371688
	normal immune system phenotype	J:371688
	increased circulating tumor necrosis factor level	J:371688
	increased IgD level	J:371688
	intestine polyps	J:371688
	ruffled hair	J:371688
Mvk^{Gt(OST201716)Lex}/Mvk^{Gt(OST201716)Lex} involves: 129S5/SvEvBrd * C57BL/6	prenatal lethality, complete penetrance	J:371688

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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